Catecholamine Metabolism, Depression and Stress

Maas, James W.; Dekirmenjian, H.; Fawcett, Jan

doi:10.1038/230330a0

Cited by 75 publications

(22 citation statements)

References 13 publications

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“…The Maas et al [1971] and the Muscettola et al [1977] studies suggest that the low MHPG found in depressed patients might result from an abnormal, perhaps reduced, response to daily life activities. Since we have recently found patients with affective disor ders, especially bipolar patients, to be espe cially pain tolerant in comparison to normals , a direct comparison of MHPG excretion during pain-induced stress in patient and normal groups appeared use ful.…”

Section: Introductionmentioning

confidence: 99%

“…In normals MHPG excre tion is not influenced by diet Muscettola et al, 1977] and motor activity [Muscettola et al, 1976;, while stressful procedures deter mine a significant increase in this NE metab olite [Rubin et al, 1970], In depressed pa tients the effect of nonspecific factors on MHPG is greater (although not all data are concurrent). It has been reported, in fact, that discontinuation of a controlled monoamine diet [Muscettola et al, 1977], induced physi cal activity [Ebert et al, 1972;Beckmann et al, 1979] and stressful procedures [Maas et al, 1971] increase urinary MHPG. Thus pa tients appear to have some functional abnor mality in noradrenergic regulation; a trait characteristic expressed as low MHPG under some particular environment.…”

Section: Introductionmentioning

confidence: 99%

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Urinary MHPG, Stress Response, Personality Factors and Somatosensory Evoked Potentials in Normal Subjects and Patients with Major Affective Disorders

Buchsbaum¹,

Muscettola²,

Goodwin³

1981

Neuropsychobiology

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Stressful procedures are reported to increase urinary MHPG in both noraml and depressed patients. Bipolar depressed patients are alos shown to be especially pain tolerant in comparison to normals. In the present study, 12 depressed patiens (6 bipolar and 6 unipolar patients) and 10 normal volunteers had average evokded potentials recorded for visual and painful electrical stumuli. MHPG urinary excretion was measured during this session and during an unstimulated resting session on the home ward. Male normal volunteers showed a significant increase in urinary MHPG under stress, while no MHPG increment was noted for the depressed patient group. Depth of depression, assessed by the Zung and Beck scales, was found to be correlated with the reduced urinary MHPG response to stress. Possible interpretations of the results are discussed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Urinary MHPG, Stress Response, Personality Factors and Somatosensory Evoked Potentials in Normal Subjects and Patients with Major Affective Disorders

Buchsbaum¹,

Muscettola²,

Goodwin³

1981

Neuropsychobiology

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“…The purpose of the present study was to examine the urinary excretion of MHPG in unipolar and bipolar depressed patients and in an age-matched group of normal controls. In addition, because of the reports that urinary MHPG excretion in depres sed patients may be affected by factors such as age (Maas et al, 1973a, b), physical activity (Ebert et al, 1972), stress (Maas et al, 1971), and the like, we have examined these and other variables in both depressed patients and in normal controls.…”

Section: Introductionmentioning

confidence: 99%

Urinary MHPG in Subgroups of Depressed Patients and Normal Controls

Beckmann¹,

Goodwin²

1980

Neuropsychobiology

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3-Methoxy-4-hydroxyphenylglycol (MHPG), the urinary metabolite thought best to reflect brain norepinephrine metabolism, was studied in a large group of hospitalized depressed patients with primary affective disorder and in normal controls, as part of an ongoing effort to evaluate the role of central amine dysfunction in affective illness. Overall there was no difference in MHPG between the depressed patients and controls. However, within the depressed population the bipolar patients excreted significantly less MHPG than the unipolars and, as a group, the male bipolar patients had significantly lower MHPG than male controls. MHPG correlated positively with age, age of onset, ratings of anxiety and psychosis and, most importantly, with systolic blood pressure. These data support the concept of biological heterogeneity among individuals with major depressive disorders. However, the relationship between MHPG excretion and various psychological and physiological parameters is both intriguing and complex and warrants careful interpretation.

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“…In addition, several investigators (Maas, Fawcett & Dekirmenjian, 1972;Schildraut, 1973;Asberg et al, 1977) (Dekirmenjian & Maas, 1970) or a fluorometric (Korf, Ottema & Vanderveen, 1971) method. Recently a more sensitive massfragmentographic method has been introduced (Bertilsson, 1980 (Steinbook, Jacobson, Weiss & Goldstein, 1979).…”

Section: Commentsmentioning

confidence: 99%

Biochemical Assessment of Antidepressive Drugs

Ghose

1981

Methods in Clinical Pharmacology—Central Nervous System

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Catecholamine Metabolism, Depression and Stress

Cited by 75 publications

References 13 publications

Urinary MHPG, Stress Response, Personality Factors and Somatosensory Evoked Potentials in Normal Subjects and Patients with Major Affective Disorders

Urinary MHPG, Stress Response, Personality Factors and Somatosensory Evoked Potentials in Normal Subjects and Patients with Major Affective Disorders

Urinary MHPG in Subgroups of Depressed Patients and Normal Controls

Biochemical Assessment of Antidepressive Drugs

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