Catecholamines in Chronic Respiratory Insufficiency

Keller, Regina; Lohmann, Friedrich; Schüren, K. P.

doi:10.1159/000192843

Cited by 13 publications

(5 citation statements)

References 23 publications

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“…Even moderate surgical trauma such as c holecystectomy is followed by a fall in muscle glycogen concentration to the same level as observed in the present RF group [16]. Furthermore, raised concentrations of the stress hormones adrenaline and noradrenaline have been reported in chronic RF [17]. The hypothesis can therefore be put forward that the RF situallon induces a stress reaction possibly via hypoxia which leads to a deterioration in muscle energy metabolism.…”

Section: Discussionsupporting

confidence: 76%

Skeletal muscle metabolites and fibre types in patients with advanced chronic obstructive pulmonary disease (COPD), with and without chronic respiratory failure

Jakobsson¹,

Jorfeldt²,

Brundin³

1990

Eur Respir J

179

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Eighteen patients with advanced COPD, 8 with chronic respiratory failure (RF) and 10 without (nonRF, NRF) were investigated using spirometry, arterial blood gas analysis and biopsies taken from the quadriceps femorls muscle. The biopsies were analysed for ATP, creatine phosphate (CrP), creatine (Cr), lactate and glycogen content. Muscle fibre composition was also studied. Low concentrations of ATP, glycogen and CrP were found in the RF patients. Significant correlations were found between muscle metabolites and arterial blood gas values with the strongest correlation between muscle glycogen and arterial PO2 (r = 0.70; p less than 0.001). A very low percentage of "oxidative" type I muscle fibres was found in both groups. Possible mechanisms causing depletion of muscle metabolites are discussed.

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Section: Discussionsupporting

confidence: 76%

Skeletal muscle metabolites and fibre types in patients with advanced chronic obstructive pulmonary disease (COPD), with and without chronic respiratory failure

Jakobsson¹,

Jorfeldt²,

Brundin³

1990

Eur Respir J

179

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“…The release of FFA and increase in concentration in the blood is pro moted by, amongst other things, catecholamines and steroids. Raised levels of catecholamines in blood has been reported in chronic respiratory failure [17]. If this is the case one would expect increased lipolysis with high concentrations of lipid metabolites in pa tients with CRF compared to those without.…”

Section: Discussionmentioning

confidence: 94%

Blood Fuel Metabolites at Rest and during Exercise in Patients with Advanced Chronic Obstructive Pulmonary Disease with and without Chronic Respiratory Failure

Jakobsson

Jorfeldt²

1990

Respiration

101

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Eighteen patients with advanced chronic obstructive pulmonary disease (COPD), 8 with chronic respiratory failure (CRF group) and 10 without (NCRF group) were investigated using arterial blood analyses before, during and after progressive exercise. Dynamic spirometry was also performed. The arterial blood was analyzed for free fatty acids (FFA), glycerol, 3-hydroxybutyrate, alanine, glucose and lactate concentrations as well as PO₂ and PCO₂. In the CRF group the concentrations of FFA, glycerol and 3-hydroxybutyrate were lower and the concentrations of glucose and lactate higher than in the NCRF group. Analysis of the whole material revealed that the arterial FFA, glycerol and 3-hydroxybutyrate concentrations correlated positively to arterial PO₂ and negatively to arterial PCO₂ at rest, as well as during exercise and recovery. The results indicate that lipolysis is decreased in patients with advanced COPD with chronic respiratory failure. An altered glucose metabolism may also exist in these patients

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“… 28 Previous studies found that COPD patients had a higher catecholamine level, possibly due to the over activation of the sympathetic nervous system (SNS) and the use of β-agonists in the treatment of COPD can also mimic the actions of sympathetic adrenergic stimulation. 21 , 22 , 29 , 30 Also, many clinical studies reported the acute exacerbation of COPD as the potential triggering factor for TCM. 21 – 23 TCM and COPD may share some similar underlying pathophysiology.…”

Section: Discussionmentioning

confidence: 99%

<p>The Impact of COPD on in-Hospital Outcomes in Patients with Takotsubo Cardiomyopathy</p>

Teng

et al. 2020

COPD

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Chronic obstructive pulmonary disease (COPD) is a known comorbidity of takotsubo cardiomyopathy (TCM), and COPD exacerbation is a potential triggering factor of TCM. The association between COPD and in-hospital outcomes and complications among TCM patients is not well established. We sought to assess the effect of COPD on hospitalized patients with a primary diagnosis of TCM. Methods: We conducted a retrospective cohort study in patients with a primary diagnosis of TCM with or without COPD using the latest National Inpatient Sample from 2016-2017. We identified 3139 patients admitted with a primary diagnosis of TCM by the ICD-10-CM coding system; 684 of those patients also had a diagnosis of COPD. We performed propensity score matching in a 1:2 ratio (n=678 patients, matched COPD group; n=1070, matched non-COPD group) and compared in-hospital outcomes and complications between TCM patients with and without a COPD diagnosis. Results: Before matching, the COPD group had worse outcomes compared with the non-COPD group in inpatient death (2.9% vs 1.3%, p=0.006), length of stay (LOS) (4.02±2.99 days vs 3.27±3.39 days, p<0.001), hospitalization charges ($55,242.68±47,637.40 vs $48,316.97±47,939.84, p=0.001), and acute respiratory failure (ARF) (22.5% vs 7.7%, p<0.001), respectively. After propensity score matching, the matched COPD group, compared with the matched non-COPD group, had a higher inpatient mortality rate (2.9% vs1.0%, p=0.005), longer LOS (4.02±3.00 days vs 3.40±3.54 days, p<0.001), higher hospitalization charges ($55,409.23±47,809.13 vs $46,469.60±42,209.10, p<0.001), and a higher incidence of ARF (22.6% vs 8.2%, p<0.001) and cardiogenic shock (5.6% vs 3.3%, p=0.024), respectively. Conclusion: Patients with COPD who are hospitalized for TCM have higher rates of inpatient mortality, ARF, cardiogenic shock, as well as a longer LOS, and higher charges of stay than those without COPD. Prospective studies are warranted to examine the effect of early intervention or treatment of COPD on short-and long-term outcomes of TCM.

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Catecholamines in Chronic Respiratory Insufficiency

Cited by 13 publications

References 23 publications

Skeletal muscle metabolites and fibre types in patients with advanced chronic obstructive pulmonary disease (COPD), with and without chronic respiratory failure

Skeletal muscle metabolites and fibre types in patients with advanced chronic obstructive pulmonary disease (COPD), with and without chronic respiratory failure

Blood Fuel Metabolites at Rest and during Exercise in Patients with Advanced Chronic Obstructive Pulmonary Disease with and without Chronic Respiratory Failure

<p>The Impact of COPD on in-Hospital Outcomes in Patients with Takotsubo Cardiomyopathy</p>

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