Non-pharmacological measures are fundamental to combat the pandemics. However, the population’s adherence is necessary in this process and, therefore, knowing their position and impressions about the effectiveness of these measures is fundamental to formulate public policies. Thus, the objective of this study was to collect the opinion of Brazilians about the non-pharmacological measures adopted to combat the COVID-19 pandemic. From March to May 2022, a cross-sectional study was carried out, of the opinion survey type, in which 703 people answered an online questionnaire containing 20 multiple-choice questions. Data were analyzed using BioEstat 5.3, Epi Info 7.2.5, and Open Epi 3.01 software. Being female, having low income, and being a public transport user were factors associated with the requirement of a vaccination card, while having a college degree, having higher income, and being a public transport user were associated with greater confidence in the non-pharmacological measures. On the other hand, not being vaccinated and having a low level of knowledge about the pandemic were factors associated with non-adherence. In the formulation of public policies aimed at controlling the pandemic, the responsible entities must emphasize the importance of non-pharmacological measures, expanding access to information in a safe, clear, and objective way for the Brazilian population.