Catharanthus Alkaloids XXIX: Isolation and Structure Elucidation of Vincoline

Catharanthus Alkaloids. XXXVI. Isolation of Vincaleukoblastine (VLB) and Periformyline From Catharanthus trichophyllus and Pericyclivine From Catharanthus roseus

“…ethanol (3:1). The band at Rf 0.15 was removed and processed to afford a crystalline substance (5.4 mg, 0.0054%), mp 186°, [a]2SD-720°(c 0.5, EtOH); ir, p max (KBr) 3340 (m, NH), 2920 (m), 1645 (s, CO), 1580 (s), 1450 (m), 1420 (m), 1290 (m), 1210 (m), 1080 (m), 1040 (m), and 730 (m) cm-1; uv, X max (MeOH) (log e) 228 (4.09), 298 (4.07) and 328 nm (4.24); pmr, (CDC13) 1.60 (d, 7=6.8 Hz, 3H, 18-CH3), 3.79 (s, 3H, C02CH3), 5.33 (m, 1H, 19-H) and 7.27-6.75 (m, 4H, 9, 10,11,12-H); cmr, see table 2; ms, m/e, M+ 322(31), 307(4), 293(2), 291 (5), 279(3), 275(3), 263 (11), 252(8), 247 (5), 238(3), 234 (8), 233(4), 225(4), 221(5), 218(6), 207 (8), 206 (15), 204 (8), 193 (11), 180 (12), 1167 (14), 166 (7), 165 (7), 154 (8), 121(51), 119 (10), 111 (12), 109 (12), 106 (11), and 97(24). These physical data are in agreement with those reported for akuammicine (2) (6), and the identity was confirmed (mmp, tic and superimposable ir) by comparison with an authentic specimen.…”

“…Preparation of alkaloid fractions of C. roseus.-The source, identification, and processing of the leaves of Calharanthus roseus have been discussed previously (8).…”

Catharanthus Alkaloids XXXIII. 21'-Oxo-Leurosine From Catharanthus Roseus (Apocynaceae)

“…Separation of the alkaloid fractions.-The source, identification, and processing of the leaves of Catharanthus roseus have been discussed previously (17).…”

Apoptotic, antioxidant and antiradical effects of majdine and isomajdine from Vinca herbacea Waldst. and kit

“…This plant has many alkaloid kinds with high amount 12 . Vincoline an alkaloid previously isolated from V. herbacea has been isolated and its structure elucidated 5 . The chemical structures of majdine and isomajdine isolated from V. herbacea Waldst.…”