Cathecholamine and 5-hydroxytryptamine levels in ischemic brain. Influence of p-chlorophenylalanine.

Welch, K. M. A.; Chabi, E; Buckingham, J; Bergin, B; Achar, V.S.; Meyer, John Stirling

doi:10.1161/01.str.8.3.341

Cited by 78 publications

(34 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Serotonin has been reported to progressively decrease only in the occluded hemisphere of ischemic animals, and preischemic depletion of brain serotonin with p-chlorophenylalanine has been reported to decrease the incidence of ischemia (Welch et al, 1977). The improvement of photothrombotic cortical ischemia with fluoxetine and sertraline is also in accordance with the results of previous studies that have emphasized on serotonergic dysfunction as an etiology of aggression in patients with depression (Van Praag, 1998) or stroke (Kim et al, 2002).…”

Section: Discussionsupporting

confidence: 80%

Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice

Shin

Kang

Lee

et al. 2009

Korean J Physiol Pharmacol

View full text Add to dashboard Cite

ABBREVIATIONS: SSRIs, serotonin reuptake inhibitors; HO-1, heme oxygenase-1; HIF-1α, hypoxia-inducible factor-1α; BBB, blood-brain barrier; rCBF, regional cerebral blood flow; MABP, mean arterial blood pressure; LL, lower limit; HSP-32, heat-shock protein. Medicine, Korea This study aimed to investigate whether selective serotonin reuptake inhibitors (SSRIs) attenuate brain injury and facilitate recovery following photothrombotic cortical ischemia in mice. Male ICR mice were anesthetized and systemically administered Rose Bengal. Permanent focal ischemia was induced in the medial frontal and somatosensory cortices by irradiating the skull with cold light laser. The animals were treated with fluoxetine or sertraline once a day for 14 d starting 1 h after ischemic insult. Treatment with fluoxetine and sertraline significantly reduced the infarct size. The Evans blue extravasation indices of the fluoxetine-and sertraline-treated groups were significantly lower than that of the vehicle group. Treatment with fluoxetine and sertraline shifted the lower limit of the mean arterial blood pressure for cerebral blood flow autoregulation toward normal, and significantly increased the expression of heme oxygenase-1 (HO-1) and hypoxia-inducible factor-1α (HIF-1α) proteins in the ischemic region. These results suggest that SSRIs, such as fluoxetine and sertraline, facilitate recovery following photothrombotic cortical ischemia via enhancement of HO-1 and HIF-1α proteins expression, thereby providing a benefit in therapy of cerebral ischemia.

show abstract

Section: Discussionsupporting

confidence: 80%

Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice

Shin

Kang

Lee

et al. 2009

Korean J Physiol Pharmacol

View full text Add to dashboard Cite

show abstract

“…Conversely, Wein berger et al reported that alpha -methyl para tyrosine treatment protected against dopa mine, serotonin and glutamate terminal damage induced by cerebral ischemia (11). Welch et al found that p-chlorophenyl alanine treatment decreased the incidence of ischemia induced by unilateral carotid arteries occlusion (12). While there are inconsisten cies in all these data, nevertheless, the results suggest that monoamine neurotransmitters have an important role in the neuronal death induced by cerebral ischemia.…”

mentioning

confidence: 97%

Changes in monoamine contents in the brains of Mongolian gerbils following a 5-min occlusion of the bilateral carotid arteries.

et al. 1989

View full text Add to dashboard Cite

“…In view of the interest in the possible effects of vasoactive substances released during an ischemic stroke 6 "' we believe our negative findings are of interest.…”

Section: Discussionmentioning

confidence: 80%

“…3 ' 4 Preliminary studies suggested little or no effect of ligation on the contractile response to norepinephrine (NOR) but an enhancing effect on the response to BaClj. 6 We have since completed a further study of this problem.…”

mentioning

confidence: 99%

Contractile responses of pial arterioles in gerbils with unilateral carotid ligation.

Rosenblum¹

1981

Stroke

View full text Add to dashboard Cite

SUMMARY Studies were made in an effort to detect enhanced rasoconstriction ipsilateral to a ligated common carotid artery. No effect of ligation was found on the response to topically administered serotonin, norepinephrine or prostaglandin F, a , in the gerbil in spite of varying a number of parameters, including anesthesia, percent of inspired oxygen, time elapsed following ligation, or body temperature at time of examination. The response was not influenced by the presence or severity of stroke symptoms. A stronger and less specific constrictor, BaO,, did elicit a difference between the contractile response of ligated and sham operated gerbils. In 13 of the 18 studies, BaCI, produced a greater constriction in the ligated gerbils, and in 9 of these studies that difference was statistically significant. In only one study was there a statistically significant contrary result. The enhanced contractile response to BaCI, could not be related to the presence or severity of symptoms or to any other of the variables mentioned above. This suggests that it was probably related to reduced intraluminal pressure distal to the ligation.Stroke, Vol 12, No I, 1981 IN 1967, Bell et al. reported that following ligation of a major cerebral vessel, the arterioles on the surface of the brain became abnormally sensitive to exogenous serotonin. 1 They ascribed this to release of serotonin (5HT) from ischemic brain and to the summation of the effect of the exogenous 5HT with that of the released (locally accumulated) endogenous 5HT. Subsequently we demonstrated enhanced pial arteriolar responses to a nonspecific spasmogen, barium ion, locally administered as BaCl 2 , in situations where intraluminal pressure was thought to be decreased. We suggested that reduced pressure, rather than ischemia, might be a causative factor in producing enhanced contractile responses following ligation of feeding arteries.2 The original observations of Bell et al. do not appear to have been pursued by others, so we elected to renew our studies by utilizing gerbils in which the carotid artery was ligated to produce a stroke.3 ' 4 Preliminary studies suggested little or no effect of ligation on the contractile response to norepinephrine (NOR) but an enhancing effect on the response to BaClj. 6 We have since completed a further study of this problem. MethodsMature gerbils of both sexes were used in approximately equal numbers as we found no influence of sex on the incidence of stroke.' The right carotid was ligated (n = 300) or sham operation performed (n = 300) under ether or ketamine anesthesia. Two to 5 h after ligation a trachiotomy and craniotomy were performed under urethane anesthesia and the arachnoid surface exposed by stripping the dura. Pial arterioles were monitored with a Leitz Ultropak microscope and their diameters measured with an image splitter and TV monitor.

show abstract

Cathecholamine and 5-hydroxytryptamine levels in ischemic brain. Influence of p-chlorophenylalanine.

Cited by 78 publications

References 22 publications

Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice

Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice

Changes in monoamine contents in the brains of Mongolian gerbils following a 5-min occlusion of the bilateral carotid arteries.

Contractile responses of pial arterioles in gerbils with unilateral carotid ligation.

Contact Info

Product

Resources

About