Cathecins in ethanolic extracts of &amp;lt;i&amp;gt;Garcinia mangostana&amp;lt;/i&amp;gt; fruit pericarp and anti-inflammatory effect in atherosclerotic rats

Adiputro, Dwi Laksono; Khotimah, Husnul; Widodo, M. Aris; Romdoni, Rochmad; Sargowo, Djanggan

doi:10.5455/jeim.250313.br.015

Cited by 4 publications

(3 citation statements)

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“…Mature G. mangostana was characterized by dark purple rinds and pleasant smell [23]. The fruits were bought from the local market, Selangor, Malaysia.…”

Section: Methodsmentioning

confidence: 99%

“…The rats were randomly divided into 5 groups according to their diet: rat chow pellet (normal control, NC; n = 8), HFD (obese control, OC; n = 8), HFD + 200 mg /kg GMF (GMF 200; n = 8), HFD + 400 mg /kg GMF (GMF 400; n = 8) and HFD + 600 mg /kg GMF (GMF 600; n = 8). The respective dosages were based on the study by Adiputro et al [23]. The rats that received HFD for 10 weeks had significantly higher body weight and body mass index (BMI) and were classified as obese [14].…”

Section: Methodsmentioning

confidence: 99%

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Mangosteen (Garcinia mangostana) flesh supplementation attenuates biochemical and morphological changes in the liver and kidney of high fat diet-induced obese rats

Adyab

Rahmat

Kadir

et al. 2019

BMC Complement Altern Med

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BackgroundMangosteen is a native fruit from Southeast Asia. It is rich in phenolic compounds such as xanthones, anthocyanins and phenolic acids. Mangosteen pericarp extract showed inhibitory activity towards pancreatic lipase and may have potential use for obesity treatment. However, there is limited study on the beneficial effects of mangosteen flesh against obesity. This study aimed to investigate the effects of Garcinia mangostana flesh (GMF) on biochemical and morphological changes in the liver and kidney of high-fat diet-induced obese rats.MethodsForty healthy Sprague-Dawley rats were randomised into five groups (n = 8) with four groups were fed with high-fat diet (HFD) for 10 weeks and a control group was fed with rat chow diet. Supplementation with GMF in obese rats was continued for 7 weeks starting from week 10th after the initiation of HFD at different doses (200 mg/kg, 400 mg/kg and 600 mg/kg). The positive and negative control rats were given distilled water via oral gavage. Plasma lipid profile, antioxidant enzymes and pro-inflammatory markers were determined using commercial kits. Liver and kidney structure were defined by histology.ResultsThe rats fed with HFD for 10 weeks increased plasma LDL-cholesterol, reduced plasma glutathione peroxidase level and had significantly higher body weight compared to normal control rats (p < 0.05). Obese rats also showed elevated level of TNF-α and IL-6 after 17 weeks of HFD. Supplementation with GMF for 7 weeks in obese rats reduced their body weight, improved lipid profile, increased total antioxidant capacity and glutathione peroxidase level and lowered plasma pro-inflammatory markers (TNF-α and IL-6) (p < 0.05). In addition, GMF supplementation attenuated the abnormalities of the liver and kidney tissue caused by high fat diet.ConclusionTaken together, the findings suggest that supplementation of Garcinia mangostana flesh may help in reducing body weight and has the potential to ameliorate the biochemical changes of the high fat diet-induced obesity in rats. Further studies on pharmacodynamic and pharmacokinetic are required before the results are translated to human.

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“…Mature G. mangostana was characterized by dark purple rinds and pleasant smell [23]. The fruits were bought from the local market, Selangor, Malaysia.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Mangosteen (Garcinia mangostana) flesh supplementation attenuates biochemical and morphological changes in the liver and kidney of high fat diet-induced obese rats

Adyab

Rahmat

Kadir

et al. 2019

BMC Complement Altern Med

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show abstract

“…Garcinia mangostana L., or commonly known as mangosteen, is rich in phenol components, such as xanthones, tannins, and anthocyanins [11]. These components have been shown to have many biological activities, and in particular, mangosteen pericarp extract has anti-inflammatory, anti-cancer, anti-microbial, and anti-oxidant effects both in vivo and in vitro [12].…”

Section: Introductionmentioning

confidence: 99%

Dietary Ethanolic Extract of Mangosteen pericarp Reduces VCAM-1, Perivascular Adipose Tissue and Aortic Intimal Medial Thickness in Hypercholesterolemic Rat Model

Wihastuti¹,

Aini²,

Tjahjono³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: High-fat diet (HFD) is associated with dyslipidemia which is a risk factor for atherosclerosis. Dyslipidemia causes oxidative stress which induces vascular cell adhesion molecule-1 (VCAM-1). Oxidative stress also triggers the thickening of tunica intima-media (IMT) and Perivascular Adipose Tissue (PVAT). Xanthone compound in ethanolic extract of Mangosteen pericarp (EEMP) has an antioxidant property to overcome the oxidative stress. AIM: The objective of this study is to investigate the effect of dietary EEMP administration on the expression of VCAM-1 and thickness of PVAT and IMT in atherosclerotic rat model fed with HFD. METHODS: This experimental laboratory study uses 25 Wistar strain Rattus norvegicus which were divided into 5 study groups. Negative Control group (GT1) was given a normal diet, Positive Control group (GT2) was treated with HFD, and three treatment groups were each treated with HFD with Mangosteen pericarp extract of 200 mg/kg BW (GT3), 400 mg/kg BW (GT4), and 800 mg/kg BW (GT5). Measurements of VCAM-1 expression were performed using immunofluorescence. PVAT and IMT measurements were performed on rat aortic preparations. RESULTS: One-way ANOVA test showed the addition of dietary EEMP significantly (p < 0.05) decreased the expression of VCAM-1 and decreased the thickness of PVAT and IMT in treatment groups as compared with both negative and positive controls. Tukey HSD test showed a dose of 800 mg/kg BW was the most effective dose for decreasing VCAM-1 level, PVAT and IMT. CONCLUSION: Dietary EEMP significantly decreases the expression of VCAM-1, as well as the thickness of PVAT and IMT in Wistar strain Rattus norvegicus treated with HFD.

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Mangosteen (Garcinia mangostana L.)

El-Kenawy

Hassan

Osman

2019

Nonvitamin and Nonmineral Nutritional Supplements

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Cathecins in ethanolic extracts of <i>Garcinia mangostana</i> fruit pericarp and anti-inflammatory effect in atherosclerotic rats

Cited by 4 publications

References 0 publications

Mangosteen (Garcinia mangostana) flesh supplementation attenuates biochemical and morphological changes in the liver and kidney of high fat diet-induced obese rats

Mangosteen (Garcinia mangostana) flesh supplementation attenuates biochemical and morphological changes in the liver and kidney of high fat diet-induced obese rats

Dietary Ethanolic Extract of Mangosteen pericarp Reduces VCAM-1, Perivascular Adipose Tissue and Aortic Intimal Medial Thickness in Hypercholesterolemic Rat Model

Mangosteen (Garcinia mangostana L.)

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