Cathelicidin antimicrobial peptides suppress EV71 infection via regulating antiviral response and inhibiting viral binding

Yu, Jie; Dai, Yue; Fu, Yuxuan; Wang, Kezhen; Yang, Yang; Li, Min; Xu, Wei; Lin, Wei

doi:10.1016/j.antiviral.2021.105021

Cited by 35 publications

(37 citation statements)

References 58 publications

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“…The inhibitory effect of LL-37 on a variety of the enveloped viruses, including human immunodeficiency virus (HIV), influenza A virus (IAV), vaccinia virus (VV), HSV, dengue virus (DENV) and Zika virus (ZIKV) [ 184 – 189 ], is achieved by destroying the viral membrane and inhibiting DNA replication. Additionally, LL-37 and mouse CRAMP markedly inhibit non-enveloped enterovirus 71 replication via regulating antiviral response and inhibiting viral binding [ 190 ]. LeMessurier et al [ 191 ] have demonstrated that AMPs altered the immune response to IAV infection, thereby enhancing the protection of the host against virus.…”

Section: Activity Of Ampsmentioning

confidence: 99%

Antimicrobial peptides: mechanism of action, activity and clinical potential

et al. 2021

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The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This comprehensive review provides a broad overview of AMPs from the origin, structural characteristics, mechanisms of action, biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics.

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Section: Activity Of Ampsmentioning

confidence: 99%

Antimicrobial peptides: mechanism of action, activity and clinical potential

et al. 2021

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“… 16 LL‐37 also had an inhibitory effect on the binding of non‐enveloped Enterovirus 71 to U251 cells. 17 A metabolite of Vitamin D3, 1α,25‐dihydroxy vitamin D3 (1,25D3), is known for its role in transcriptional regulation of many genes of the immune system. 18 Genes regulated by 1,25D3 also code for anti‐microbial peptides.…”

Section: Introductionmentioning

confidence: 99%

“…Binding of Respiratory Syncytial Virus to epithelial cells is diminished by LL‐37 16 . LL‐37 also had an inhibitory effect on the binding of non‐enveloped Enterovirus 71 to U251 cells 17 . A metabolite of Vitamin D3, 1α,25‐dihydroxy vitamin D3 (1,25D3), is known for its role in transcriptional regulation of many genes of the immune system 18 .…”

Section: Introductionmentioning

confidence: 99%

An in silico scientific basis for LL‐37 as a therapeutic for Covid‐19

et al. 2021

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A multi‐pronged approach with help in all forms possible is essential to completely overcome the Covid‐19 pandemic. There is a requirement to research as many new and different types of approaches as possible to cater to the entire world population, complementing the vaccines with promising results. The need is also because SARS‐CoV‐2 has several unknown or variable facets which get revealed from time to time. In this work, in silico scientific findings are presented, which are indicative of the potential for the use of the LL‐37 human anti‐microbial peptide as a therapeutic against SARS‐CoV‐2. This indication is based on the high structural similarity of LL‐37 to the N‐terminal helix, with which the virus interacts, of the receptor for SARS‐CoV‐2, Angiotensin Converting Enzyme 2. Moreover, there is positive prediction of binding of LL‐37 to the receptor‐binding domain of SARS‐CoV‐2; this is the first study to have described this interaction. In silico data on the safety of LL‐37 are also reported. As Vitamin D is known to upregulate the expression of LL‐37, the vitamin is a candidate preventive molecule. This work provides the possible basis for an inverse correlation between Vitamin D levels in the body and the severity of or susceptibility to Covid‐19, as widely reported in literature. With the scientific link put forth herein, Vitamin D could be used at an effective, medically prescribed, safe dose as a preventive. The information in this report would be valuable in bolstering the worldwide efforts to eliminate the pandemic as early as possible.

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“…Alternative antiviral mechanisms have been also reported against non-enveloped viruses. Human LL-37 and mCRAMP have been recently shown to significantly reduce nonenveloped enterovirus 71 (EV71) infection in vitro and in vivo [50]. Co-incubation of LL-37 and mCRAMP peptides with U251 cells enhanced the basal interferon-β (IFN-β) expression and interferon regulatory transcription factor 3 phosphorylation upon EV71 infection.…”

Section: Cathelicidinsmentioning

confidence: 99%

“…Co-incubation of LL-37 and mCRAMP peptides with U251 cells enhanced the basal interferon-β (IFN-β) expression and interferon regulatory transcription factor 3 phosphorylation upon EV71 infection. Yu et al [50] also showed that these peptides directly suppressed EV71 binding to U251 cells, although the inhibitory mechanism remains unclear.…”

Section: Cathelicidinsmentioning

confidence: 99%

Natural antimicrobial peptides as a source of new antiviral agents

Zakaryan

Chilingaryan

Arabyan

et al. 2021

Journal of General Virology

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Current antiviral drugs are limited because of their adverse side effects and increased rate of resistance. In recent decades, much scientific effort has been invested in the discovery of new synthetic and natural compounds with promising antiviral properties. Among this new generation of compounds, antimicrobial peptides with antiviral activity have been described and are attracting attention due to their mechanism of action and biological properties. To understand the potential of antiviral peptides (AVPs), we analyse the antiviral activity of well-known AVP families isolated from different natural sources, discuss their physical–chemical properties, and demonstrate how AVP databases can guide us to design synthetic AVPs with better therapeutic properties. All considerations in this sphere of antiviral therapy clearly demonstrate the remarkable contribution that AVPs may make in conquering old as well as newly emerging viruses that plague humanity.

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Cathelicidin antimicrobial peptides suppress EV71 infection via regulating antiviral response and inhibiting viral binding

Cited by 35 publications

References 58 publications

Antimicrobial peptides: mechanism of action, activity and clinical potential

Antimicrobial peptides: mechanism of action, activity and clinical potential

An in silico scientific basis for LL‐37 as a therapeutic for Covid‐19

Natural antimicrobial peptides as a source of new antiviral agents

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