1988
DOI: 10.1016/0736-5748(88)90035-4
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Cathepsin D and 2′,3′‐cyclic nucleotide 3′‐phosphohydrolase in developing human foetal brain

Abstract: Three peaks of proteinases were observed with hemoglobin, bovine serum albumin and casein as substrates at the pH of 3.5, 6.5 and 8.5, in prenatal human cerebral cortex. Cathepsin D (EC 3.4.23.5) was the most prominent, with hemoglobin as the preferred substrate. The enzyme was partially purified by Concanavalin A - Sepharose affinity chromatography and the nature of the active site was assessed with proteinase inhibitors. Inhibitor studies showed that similar to pepstatin A, benzethonium chloride was also str… Show more

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