Cathepsin D as an Indicator of Clinical Outcome in Early Breast Carcinoma During the First 3 Years of Follow-Up

Markicevic, Milan; Kanjer, Ksenija; Mandušić, Vesna; Buta, Marko; Nešković-Konstantinović, Z.; Nikolić‐Vukosavljević, Dragica

doi:10.2217/bmm.13.62

Cited by 9 publications

(10 citation statements)

References 40 publications

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“…Cathepsin D protein has been reported to be overexpressed in breast cancer and hyper-secreted by epithelial breast cancer cells ( 21 , 32 , 33 ). Other previous studies have suggested that cathepsin D expression may be an independent predictor for poor prognosis of breast cancer patients as cathepsin D expression was associated with a high incidence of cancer metastasis ( 20 , 34 ). Consistent with these previous findings, the current study also demonstrated that high expression of cathepsin D protein was associated with poor prognosis of breast cancer patients; however, multivariate analysis failed to indicate that this was an independent predictor of disease-free survival.…”

Section: Discussionmentioning

confidence: 93%

Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients

et al. 2015

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Breast cancer is one of the most prevalent types of cancer in women and contributes to 32% of all female cancer cases. Cathepsins, a family of proteins, are known to have a critical role in human cancers. However, previous studies on the systematic analysis of the role of cathepsin family members in breast cancer are limited. The aim of the present study was to identify biological markers to predict prognosis and treatment response of breast cancer patients, as well as to elucidate novel therapeutic targets. The present study analyzed the expression of six members of cathepsin family, including cathepsins B, G, D, K, L and V in 188 breast cancer tissue specimens using immunohistochemistry. The data showed that all members of the tested cathepsin families featured cytoplasmic staining. Notably, expression of cathepsin L was associated with advanced tumor stages, while cathepsins B and K expression levels were associated with positive estrogen receptor expression; in addition, cathepsin K expression was also demonstrated to be associated with progesterone receptor expression. Cathepsins V and D expression levels were found to be associated with breast cancer metastasis, while the expression levels of cathepsins B and D were associated with poor disease-free survival in breast cancer patients. In addition, univariate analysis demonstrated that breast cancer metastasis to the bone and the expression of cathepsin B protein were associated with poor disease-free survival. In conclusion, the results of the present study indicated that the altered expression of cathepsins, in particular cathepsins B and D, contributed to the progression of breast cancer and poor disease-free survival in breast cancer patients.

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Section: Discussionmentioning

confidence: 93%

Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients

et al. 2015

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“…Among the patients with positive lymph nodes, those with tumor cells immunopositive for CTSD had a higher risk of relapse [ 21 ]. Determination of CTSD status in breast cancer patients might help identify those with different risk levels of relapse [ 22 ]. Our previous work suggests that CTSB and CTSD are associated with NPC metastasis [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic values of serum cathepsin B and D in patients with nasopharyngeal carcinoma

et al. 2016

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BackgroundThe diagnostic and prognostic significance of increased cathepsin B (CTSB) and cathepsin D (CTSD) concentration in the serum of cancer patients were evaluated for some tumor types. High expression of CTSD and CTSB was detected in biopsy tissues from nasopharyngeal carcinoma (NPC). However, whether CTSD and CTSB serve as diagnostic and prognostic markers of NPC remains unclear.MethodsSerum samples were collected from 40 healthy volunteers and 80 NPC patients enrolled in the study. CTSB and CTSD in the serum samples were detected using enzyme-linked immunosorbent assay (ELISA). Concomitantly, the relationship between CTSB and CTSD concentrations and clinicopathological prognosis was assessed. The sensitivity and specificity of the two components in the diagnosis of NPC were evaluated in 80 NPC patients.ResultsELISA analysis showed that in the sera obtained from NPC patients, the CTSB concentration was 12.5 ± 3.5 mg/L (median, 12.4 mg/L), and the CTSD concentration was 15.7 ± 8.7 mg/L (median, 14.7 mg/L). CTSB and CTSD levels were significantly higher in the NPC patient population compared to the healthy control population (p = 0.001; p = 0.001, respectively). The presence of CTSB and CTSD in the serum of the patients with NPC correlated with the tumor node metastasis (TNM) scores (p = 0.001). Other parameters were not identified to be of significance. Receiver operating characteristic (ROC) analysis showed that a cut off CTSB concentration of 12.4 mg/L had 61.9 % sensitivity and 63.2 % specificity in the prediction of progression-free survival (Area under the curve (AUC) = 0.525; 95 % CI, 39.7–65.2; p = 0.704); whereas a cut off CTSD concentration of 14.7 mg/L had 66.7 % sensitivity, and 58.5 % specificity (AUC = 0.552; 95 % CI, 42.3–68.1; p = 0.42).ConclusionsSerum CTSB and CTSD concentrations were found to have a diagnostic value in NPC. However, the CTSB and CTSD serum levels had no prognostic role for the outcome in NPC patients.

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“…Such patients are increasingly difficult to find due to a trend of widening systemic therapy use [16]. The patient group was assembled from a period of over 20 years ago when low metastasis risk patients have not been prescribed systemic therapy at our institution.…”

Section: Discussionmentioning

confidence: 99%

“…Our data indicate that high FD associates with high distant metastasis risk. With FD regarded as a formal means of quantifying shape complexity [11,16], it can be considered that high structural complexity of H&E stained tumour tissue associates with high risk. This result is consistent with the previously reported prognostic value of FD obtained on pan-cytokeratin stained breast tumour tissue sections [14].…”

Section: Discussionmentioning

confidence: 99%

“…The reproducibility of the analysis was based on the settings for the range of box sizes (scale window) defined as 2,4,8,16,32,64,128,256, 512, 1024 pixels. With the pixel size of 145 nm the grid lengths ranged between 0.29 m and 148 m. Furthermore, scan background setting was locked to white in order to avoid the inversion of the binary image from white to black background during analysis.…”

Section: Matherials and Methodsmentioning

confidence: 99%

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Fractal Parameters of Tumour Microscopic Images as Prognostic Indicators of Clinical Outcome in Early Breast Cancer

Pribic¹,

Vasiljević

Kanjer³

et al. 2017

Computer Science &Amp; Information Technology (CS &Amp; IT)

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Cathepsin D as an Indicator of Clinical Outcome in Early Breast Carcinoma During the First 3 Years of Follow-Up

Abstract: Determination of cathepsin D status in breast cancer might identify patients at different risk for relapse and might facilitate the selection of more or less aggressive adjuvant therapy for early breast cancer patients during the first 3 years of follow-up.

Cited by 9 publications

References 40 publications

Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients

Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients

Diagnostic values of serum cathepsin B and D in patients with nasopharyngeal carcinoma

Fractal Parameters of Tumour Microscopic Images as Prognostic Indicators of Clinical Outcome in Early Breast Cancer

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