Catheter-related Bacteremia Caused by Agrobacterium radiobacter in a Hemodialysis Patient

Hanada, Shigeru; Iwamoto, Mari; Kobayashi, Naho; Ando, Ryoichi; Sasaki, Sei

doi:10.2169/internalmedicine.48.1754

Cited by 14 publications

(10 citation statements)

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“…R. radiobacter includes the former synonymic species Agrobacterium radiobacter and Agrobacterium tumefaciens, which could be differentiated only by the presence of tumorigenic (Ti) plasmids. R. radiobacter has been occasionally associated with opportunistic infections in humans, including bacteremia (especially catheter-related bacteremia) (2,4,9,11,15,16,21,22), pneumonia (17), urinary tract infections (1), peritonitis (12,26), and endocarditis (25). Most of these infections occurred in hospital settings (14), in patients with immunosuppression (e.g., hematologic malignancies, solid-organ cancers, HIV infection, or organ transplantation) (6,8,13,17), and/or in patients bearing a foreign material (e.g., central catheter) (4,11,14,15,21).…”

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confidence: 99%

Three Cases of Post-Cataract Surgery Endophthalmitis Due to Rhizobium (Agrobacterium) radiobacter

et al. 2012

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We present three unrelated post-cataract surgery endophthalmitis cases caused by Rhizobium radiobacter, hospitalized in three different hospitals. Early diagnosis was obtained in two cases by bacterial DNA detection in vitreous samples. All patients recovered from infection, but pars plana vitrectomy was needed in two patients due to rapid clinical deterioration. CASE REPORTSP atient 1. An 81-year-old female patient complained of decreased visual acuity (20/63) 4 weeks after cataract surgery (phacoemulsification) of the right eye (Table 1). Acute postoperative endophthalmitis with severe ocular inflammation was diagnosed. Vitreous (200-l) and aqueous humor (AH; 150-to 200-l) samples were tested by culture using brain heart infusion broth (AES Laboratories, Combourg, France) and eubacterial PCR, as previously described (5). Rhizobium radiobacter was detected by culture in AH and vitreous and by eubacterial PCR in the vitreous. Species identification was confirmed by PCR amplification and sequencing of the 16S rRNA gene (GenBank accession number JQ304788) from the vitreous sample and from isolated colonies, whereas phenotypic identification of the isolated strain remained ambiguous. A 440-bp DNA fragment of the 16S rRNA gene was amplified with primers 91E and 13BS as described by Gauduchon et al. (10). The amplicon was sequenced, and the sequence obtained was compared in a phylogenetic analysis with those available in the BIBI database (http://umr5558-sud-str1 .univ-lyon1.fr/lebibi/lebibi.cgi). Using an agar disk diffusion method (7), the strain was found to be intermediately susceptible to broad-spectrum cephalosporins (especially ceftazidime) but susceptible to cefepime, imipenem, and fluoroquinolones according to the interpretative criteria of the CLSI for Pseudomonas aeruginosa, as previously suggested (14). The patient received two intravitreal injections of vancomycin (1 mg) and ceftazidime (2 mg) on the day of admission and 4 days later, systemic antibiotics for 7 days (intravenous imipenem at 500 mg three times a day and ciprofloxacin at 500 mg orally twice a day), subconjunctival injections of dexamethasone, and topical steroid therapy. One year later, the outcome was favorable.Patient 2. A 75-year-old male patient presented with acute endophthalmitis of moderate severity (Table 1; Fig. 1), 9 days after an uncomplicated phacoemulsification. He was followed up for obstructive sleep apnea and hypertension. Vitreous and AH were sampled, and the patient received an intravitreal injection of vancomycin plus ceftazidime, a systemic antibiotic therapy (intravenous piperacillin at 4 g three times a day and levofloxacin orally at 500 mg once a day, for 7 days), and topical steroid therapy. The following day, visual acuity was reduced to light perception, a 1-mm hypopyon appeared, and a pupillary membrane prevented fundus examination. Pars plana vitrectomy (PPV) was performed on day 3 of hospitalization, and intravitreal injections of antibiotics were repeated the same day and 2 days later. R. radiobacter was detec...

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Three Cases of Post-Cataract Surgery Endophthalmitis Due to Rhizobium (Agrobacterium) radiobacter

et al. 2012

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“…7,8 Hastalar bakteriyemi, peritoneal diyaliz kaynaklı peritonit, üriner sistem enfeksiyonu ve nadir olarak da selülit, endoftalmit ya da pnömoni ile prezante olabilmektedir. Türki-ye'de ise ilk vaka olan ve 2008 yılında Taşbakan ve ark.…”

Section: Discussionunclassified

Rhizobium Radiobacter Bacteremia in Miliary Tuberculosis: Case Report

Turhan¹,

Gündoğan²,

Özkisa³

et al. 2016

Turkiye Klinikleri Arch Lung

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“…Several case studies reported infection of immunocompromised or other sensitive individuals by Agrobacterium radiobacter, most often causing blood(stream) infection or peritonitis (e.g. Hanada et al, 2009;Kato et al, 2009;Lai et al, 2004;Tsai, 2013), which were in some cases catheter-related. However, host sensitivity is a common risk-defining parameter in all reports retrieved, and Agrobacterium radiobacter strain K84 has been positively evaluated in the risk assessment and included in Regulation (EU) 540/2011.…”

Section: Pathogenicity Traits Of Selected Microorganisms Within the Smentioning

confidence: 99%

Literature search and data collection on RA for human health for microorganisms used as plant protection products

Hackl

Pacher‐Zavisin

Sedman

et al. 2015

EFSA Supporting Publications

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A knowledge base of scientific and regulatory data relevant in the context of risk assessment of microbial plant protection products (PPPs) for human health was established, taking into consideration conditions 1 to 4 in Regulation (EU) 546/2011 that must be met before authorisation can be granted. We screened scientific publications and documents from governmental and institutional sources and extracted relevant information into a database, performed comparative genome analyses to explore possibilities and limitations of applying read-across among PPP strains, and discussed the collective findings among a group of experts in relevant fields. Besides information on factors relevant for the evaluation of microbial PPP strains regarding pathogenicity, infectivity, and toxicity, information was collected on methods used to analyse the PPP species' ability to persist and grow in test animals, for detecting microbial DNA transfer, for testing microbial compounds for potential toxicity, and for detecting toxin production from PPP strains. Questions arising from the reviewed scientific and grey literature were how to address the specific biological properties of PPP strains and how to take into consideration realistic exposure scenarios and a natural background of environmental microorganisms in the risk assessment. Results from the present work imply that pathogenicity traits have to be considered as strain specific and that, hence, read-across comparison cannot be used. From a scientific point of view, it was highly recommended to provide whole genome sequencing data of PPP strains to allow their unambiguous identification, while other technological developments such as the use of metabolomics data were seen as an option for future implementation. It is envisaged to further develop the key topics of the present work at a joint stakeholder workshop as the next step towards the preparation of a guidance document by the PPR panel on how to conduct the regulatory risk assessment for microbial pesticides. © Efsa 2015Key words: microorganism, pesticide, risk assessment, human health, toxicity, read-across, DNA sequencing Disclaimer: The present document has been produced and adopted by the bodies identified above as authors. This task has been carried out exclusively by the authors in the context of a contract between the European Food Safety Authority and the authors, awarded following a tender procedure. The present document is published complying with the transparency principle to which the Authority is subject. It may not be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors.Suggested citation: Evelyn Hackl1), Margit Pacher-Zavisin2), Laura Sedman1), Stefan Arthaber1), Ulla Bernkopf1), Günter Brader1), Markus Gorfer1), Birgit Mitter1), Aspasia Mitropoulou1), Monika Schmoll1), Willem van Hoesel1), Elisabeth Wis...

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Catheter-related Bacteremia Caused by Agrobacterium radiobacter in a Hemodialysis Patient

Abstract: Abstract

Cited by 14 publications

References 13 publications

Three Cases of Post-Cataract Surgery Endophthalmitis Due to Rhizobium (Agrobacterium) radiobacter

Three Cases of Post-Cataract Surgery Endophthalmitis Due to Rhizobium (Agrobacterium) radiobacter

Rhizobium Radiobacter Bacteremia in Miliary Tuberculosis: Case Report

Literature search and data collection on RA for human health for microorganisms used as plant protection products

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