Cation Distribution in the Muscles of Adrenalectomized Rats

Buell, Mary V.; Turner, Eleanor

doi:10.1152/ajplegacy.1941.134.2.225

Cited by 24 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are consistent with the observations of Fenn and Haege (19) that excised frog muscles lose potassium in the presence of excess magnesium. Buell and Turner (20) found that the skeletal muscle of adrenalectomized rats lost magnesium in a fixed ratio to its gain in potassium. The balance studies of Orent-Keiles and McCollum (18) showed that rats on a potassium-deficient diet consistently retained more than twice as much magnesium as did the control rats.…”

Section: Discussionmentioning

confidence: 99%

Effect of Potassium Deficiency on Carbon Dioxide, Cation, and Phosphate Content of Muscle

Gardner

MacLachlan

Berman

1952

Journal of General Physiology

View full text Add to dashboard Cite

Albino rats weighing 160 to 175 gm. were fed a complete synthetic diet containing 0.003 per cent potassium and 0.7 per cent sodium for 40 days. Controls were given the same diet plus adequate added potassium. 1. Data from analyses of serum and skeletal muscle showed (a) a fall in serum chloride concentration and an increase in serum carbon dioxide concentration and pH in the potassium-deficient rats; (b) increases of sodium, magnesium, and calcium and a decrease of potassium in the muscle of the potassium-deficient rats; (c) no change of muscle chloride or carbon dioxide concentrations in the potassium-deficient rats. (2) Application of the Wallace-Hastings calculations to these data revealed (a) intracellular pH of the skeletal muscle of the normal rat to be 6.98 ± 0.08; (b) an increase in serum partial pressure of carbon dioxide (pCO2) in potassium deficiency, together with increases in concentrations of [H2CO2] and [HCO3-] per kg. extracellular water and [H2CO3] per kg. cell water; (c) a decrease in values for [CO2] and [HCO3-] per kg. intracellular water; (d) a fall of intracellular pH in potassium deficiency to 6.42 ± 0.05. (3) Analyses of sacrospinalis muscle from five men undergoing operation for ruptured intervertebral disc showed a mean value of 9.46 ± 1.31 mM carbon dioxide per kg. blood-free tissue. Some problems of interpretation of data are briefly discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Potassium Deficiency on Carbon Dioxide, Cation, and Phosphate Content of Muscle

Gardner

MacLachlan

Berman

1952

Journal of General Physiology

View full text Add to dashboard Cite

show abstract

“…This group and Flanagan et al (1950) suggested that cells or bone may act as a labile store for sodium in this condition. However, other workers (Harrison & Darrow, 1938 ;Muntwyler, Mellors, Mautz & Mangun, 1940;Buell & Turner, 1941) found no increase in tissue sodium content in adrenalectomized dogs, and Rolf, Armstrong, Steiger, Audia & White (1959) reported that in adrenalectomized rats the external loss of sodium accounted for the degree of extracellular depletion.…”

Section: Discussionmentioning

confidence: 94%

The Effect of Glucocorticoid Withdrawal on Body Water and Electrolytes in Hypopituitary Patients with Adrenocortical Insufficiency as Investigated with 77Br, 43K, 24Na and 3H2O

et al. 1972

View full text Add to dashboard Cite

1.Simultaneous measurements of exchangeable Na+, exchangeable K+ , extracellular fluid volume and total body water, with 24Na, 43K, "Br and 3Hz0, were carried out in patients with adrenocortical insufficiency due to pituitary ablation performed 1-3 months previously.2. The first group of five patients was studied before and after withdrawal of maintenance prednisone (2.5 mg three times daily, orally). The effects of glucocorticoid withdrawal were: (a) an increase in intracellular water (all cases) and a decrease in the extracellular fluid volume (four cases) irrespective of any change in serum Na' concentration; (b) an increase in residual ('intracellular') Na+ in all cases which was matched by a loss of extracellular Na', so that total body Na' remained unchanged, and (c) the cortisol deficiency clinical syndrome. Exchangeable K' remained unchanged.3. Similar measurements were obtained with two further patients during the corticosteroid withdrawal period, throughout which they were kept on a maintenance dose of deoxycorticosterone acetate, 1.0 mg twice daily sublingually. Neither the above biochemical changes nor the cortisol deficiency syndrome developed.4. The shift into the cells of water and Na' may depend on the same defect caused by glucocorticoid deficiency, and may be the cause of the cortisol deficiency syndrome.Key words : exchangeable electrolytes, cyclotron-produced isotopes, pituitary and adrenal insdliciency.The accepted concept (Travis & Sayers, 1965; Liddle, 1968) of the events in acute total adrenocortical insufficiency is simply that renal loss of sodium in excess of water occurs, causing hyponatraemia and a consequent passive transfer of water from the extracellular fluid into the

show abstract

“…1940) to be accom panied b y a loss of in tra cellular sodium and accum ulation of potassium in RBC. R estoration w ith cortexone, ad ren al cortical extract a n d /o r salt, reverses this phenom enon (Buell and Turner, 1941). The red istrib u tio n of electrolytes and w ater begins w ithin one h o u r a fte r receiving the first horm one injection.…”

Section: Discussionmentioning

confidence: 98%

Acute Effects of ACTH, Cortisol, Prednisolone and Dexamethasone on Electrolyte and Water Content of Red Blood Cells

Waltner¹,

M²

1959

Pharmacology

View full text Add to dashboard Cite

Cation Distribution in the Muscles of Adrenalectomized Rats

Cited by 24 publications

References 0 publications

Effect of Potassium Deficiency on Carbon Dioxide, Cation, and Phosphate Content of Muscle

Effect of Potassium Deficiency on Carbon Dioxide, Cation, and Phosphate Content of Muscle

The Effect of Glucocorticoid Withdrawal on Body Water and Electrolytes in Hypopituitary Patients with Adrenocortical Insufficiency as Investigated with 77Br, 43K, 24Na and 3H2O

Acute Effects of ACTH, Cortisol, Prednisolone and Dexamethasone on Electrolyte and Water Content of Red Blood Cells

Contact Info

Product

Resources

About