Cationic polymers and aptamers mediated aggregation of gold nanoparticles for the colorimetric detection of arsenic(iii) in aqueous solution

Wu, Yuangen; Zhan, Shenshan; Wang, Faze; He, Lan; Zhi, Wenting; Zhou, Pei

doi:10.1039/c2cc30384a

Cited by 230 publications

(116 citation statements)

References 19 publications

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“…Inorganic As contamination is a pressing environmental issue that causes a serious threat to human health. 16 MG is a cationic dye that is widely used as an antiseptic in the aquaculture industry, but it is suspected of being genotoxic and carcinogenic. 17,18 Recent studies showed that SERS is a promising technique for rapid detection of MG [19][20][21][22] and As(v), [23][24][25][26] but the method sensitivity and selectivity require further improvement, and a fast, highly efficient and low-cost procedure for preparation of SERS substrates is urgently needed.…”

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confidence: 99%

Coffee-ring effect-based simultaneous SERS substrate fabrication and analyte enrichment for trace analysis

et al. 2014

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Based on the "coffee-ring effect", we developed a highly efficient SERS platform which integrates the fabrication of SERS-active substrates and the preconcentration of analytes into one step. The high sensitivity, robustness, reproducibility and simplicity make this platform ideal for on-site analysis of small volume samples at low concentrations in complex matrices.Since its invention in the 1970s, 1,2 surface-enhanced Raman spectroscopy (SERS) has been receiving growing interest in a variety of areas due to its inherent merits such as a high signalto-noise ratio, non-photobleaching features and the use of single photoexcitation. 3 These features make SERS one of the most powerful techniques for non-destructive, on-site and in vivo analysis of chemical and biological substances. 4 However, the utilization of SERS in determination of trace analytes is restricted by the sophisticated and expensive nanofabrication of highly SERS-active substrates, as well as its limited sensitivity and selectivity for trace substances in complex matrices due to the swamping of the analyte signal in background molecule signals. For example, while the concentrations of PAHs in the environment are commonly in the range of 10 À12 to 10 À9 g L À1 , the lowest detection limits available with a well-designed SERS substrate are in the range of 3 Â 10 À6 to 1.78 Â 10 À4 g L À1 . 5 To meet the requirements for analysis of trace analytes in complex matrices, metallic substrates were tailored to increase the signal strength, and analytes were preconcentrated before SERS analysis. As these two approaches are very complicated and timeconsuming, it is highly desired to develop a fast, simple and robust approach to simultaneously perform the self-assembling of SERS substrates and preconcentration of trace analytes.One technique that holds great promise in this regard is the "coffee-ring effect", which refers to the accumulation of a ringlike dense array on the border by evaporating a droplet of aqueous solution containing nonvolatile solutes such as organic small molecules, biomacromolecules, polymers, and nanoparticle microspheres on solid surfaces. In this process, the three-phase contact line among the atmosphere, droplet and solid substrate is pinned, and a remarkable capillary ow happens because of the evaporation of solvents, driving solutes to move outward from the inner side to the rim of the droplet. Consequently, solutes are highly concentrated along the original droplet edge. It was found that the coffee-ring effect is applicable for enriching both chemical and biological substances. 6-11 One example is its application in normal Raman spectrometry that is termed as drop coating deposition Raman (DCDR). 10 In recent years, the coffee-ring effect has become a powerful tool for self-structuring of nanomaterials. [12][13][14][15] Herein, we report the development of a novel SERS platform by integrating the generation of SERS substrates and the enrichment of analytes into one step. We demonstrate the benets of the coffee-ring effect in co...

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confidence: 99%

Coffee-ring effect-based simultaneous SERS substrate fabrication and analyte enrichment for trace analysis

et al. 2014

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“…Noble metal nanomaterials (e.g., Au and Ag) have been commonly used to develop highly sensitive colorimetric probes for the determination of biomolecules 21,22 , drugs 23 , toxicants [24][25][26][27][28] and small molecules [29][30][31] due to their optical and electrical properties and biocompatibility 32,33 . Ag nano materials are more cost effective in their preparation than Au nano materials.…”

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles-Based Nano-drop Spectrophotometric Determination of Cationic Surfactants Coupled with Hydrophobic Interaction; An Application to Pharmaceuticals and Environmental

Sharma¹,

Tapadia²

2016

Orient. J. Chem

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The proposed work describes the nanodrop spectrophotometric determination of cationic surfactants using citrate-modified silver nanoparticles based on the aggregation of silver nanoparticles induced by cationic surfactants due to the hydrophobic effect. The visible color change in the solution of silver nanoparticle includes a red shift with the quenching of the absorption spectra. The maximum absorbance was measured at wavelength, λ max 400 nm. The concentrations of cationic surfactants were determined using a nanodrop spectrophotometer with limits of detection of 15.0, 8.0, 6.0, 5.8, and 13.0 µM for dodecyl trimethyl ammonium bromide, myristil trimethyl ammonium bromide, cetrimonium trimethyl ammonium bromide, cetyl pyridinium chloride and benzalkonium chloride, respectively. The proposed method was successfully applied for the determination of cetyl pyridinium chloride in commercial mouthwasher, gum astringent and nasal spray pharmaceuticals and environmental samples.

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“…The nanoparticles are stabilized by the adsorbed oligonucleotides at high salt concentration, and aggregated when the target is present, leading to a change in colour. However, the high assembly time of the above assay coupled with relatively poor (low nano-molar) detection limits using salts prompted the use of other ionic agents like conjugated polyelectrolytes [10], cationic polymers [11] and cationic surfactants [12] instead of salt, for the development of AuNP aggregation-based detection assays.…”

Section: Introductionmentioning

confidence: 99%

Aromatic Surfactant as Aggregating Agent for Aptamer-Gold Nanoparticle-Based Detection of Plasmodium Lactate Dehydrogenase

et al. 2016

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A novel ssDNA aptamer (P38), with a 40 mer random region flanked by primer-binding sites on both sides, targeting Plasmodium falciparum lactate dehydrogenase (PfLDH) has been developed through systematic evolution of ligands by exponential enrichment (SELEX), including counter SELEX against human lactate dehydrogenase A and B (hLDH A and B). The 2D structure of P38 shows the presence of three stem loops with a δG of -9.18 kcal/mol. EMSA studies on P38 complexes with the increasing concentration of PfLDH revealed a dissociation constant of 0.35 µM. P38 has been exploited for the quantitative detection of PfLDH using cationic surfactant-mediated aggregation of gold nanoparticles (16-nm diameter) as an optical probe. Among the three different cationic surfactants, characterized by different hydrocarbon tail groups, benzalkonium chloride (BCK) was found to be most efficient with a limit of detection of 281 ± 11 pM. This BCK-based approach with the novel highly selective aptamer provides simple and sensitive detection of PfLDH in the clinically relevant range.

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Cationic polymers and aptamers mediated aggregation of gold nanoparticles for the colorimetric detection of arsenic(iii) in aqueous solution

Cited by 230 publications

References 19 publications

Coffee-ring effect-based simultaneous SERS substrate fabrication and analyte enrichment for trace analysis

Coffee-ring effect-based simultaneous SERS substrate fabrication and analyte enrichment for trace analysis

Silver Nanoparticles-Based Nano-drop Spectrophotometric Determination of Cationic Surfactants Coupled with Hydrophobic Interaction; An Application to Pharmaceuticals and Environmental

Aromatic Surfactant as Aggregating Agent for Aptamer-Gold Nanoparticle-Based Detection of Plasmodium Lactate Dehydrogenase

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