Cationic polystyrene nanoparticle and the sea urchin immune system: biocorona formation, cell toxicity, and multixenobiotic resistance phenotype

Marques‐Santos, Luis Fernando; Grassi, Giacomo; Bergami, Elisa; Faleri, Claudia; Balbi, Teresa; Salis, Annalisa; Damonte, Gianluca; Canesi, Laura; Corsi, Ilaria

doi:10.1080/17435390.2018.1482378

Cited by 71 publications

(49 citation statements)

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ecotoxicological effects of MPs/NPs on marine phyto/zooplanktons, invertebrates, and plants are widely documented [20][21][22][23][24][25][26][27][28][29][30], and have been recently reviewed [5,[31][32][33]. MPs/NPs could also be ingested and accumulated in larger marine fauna by trophic transfer from prey to predator, as demonstrated earlier with invertebrates, such as mussel-consuming crabs [34].…”

Section: Introductionmentioning

confidence: 88%

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Yong

Valiyaveettil

Tang

2020

IJERPH

555

280

View full text Add to dashboard Cite

Fragmented or otherwise miniaturized plastic materials in the form of micro- or nanoplastics have been of nagging environmental concern. Perturbation of organismal physiology and behavior by micro- and nanoplastics have been widely documented for marine invertebrates. Some of these effects are also manifested by larger marine vertebrates such as fishes. More recently, possible effects of micro- and nanoplastics on mammalian gut microbiota as well as host cellular and metabolic toxicity have been reported in mouse models. Human exposure to micro- and nanoplastics occurs largely through ingestion, as these are found in food or derived from food packaging, but also in a less well-defined manner though inhalation. The pathophysiological consequences of acute and chronic micro- and nanoplastics exposure in the mammalian system, particularly humans, are yet unclear. In this review, we focus on the recent findings related to the potential toxicity and detrimental effects of micro- and nanoplastics as demonstrated in mouse models as well as human cell lines. The prevailing data suggest that micro- and nanoplastics accumulation in mammalian and human tissues would likely have negative, yet unclear long-term consequences. There is a need for cellular and systemic toxicity due to micro- and nanoplastics to be better illuminated, and the underlying mechanisms defined by further work.

show abstract

Section: Introductionmentioning

confidence: 88%

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Yong

Valiyaveettil

Tang

2020

IJERPH

555

280

View full text Add to dashboard Cite

show abstract

“…Amino-modified polystyrene particles acquired a protein corona once incubated with celomic fluid, dominated by the toposome precursor protein, which triggers particle−coelomocytes interactions and toxicity. 87 Wegner et al showed that 30 nm polystyrene nanoparticles, that were tested at concentrations of 0.1−0.3 g/L, have an adverse effect on the feeding behavior of the blue mussel Mytilus edulis because of a reduced filtering activity in the presence of the particles. 88 Pitt et al investigated the potential toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio) and characterized the uptake and distribution of the particles within embryos and larvae.…”

Section: Sources and Fate Of Plastic In The Environmentmentioning

confidence: 99%

Emergence of Nanoplastic in the Environment and Possible Impact on Human Health

Lehner

Weder

Petri‐Fink

et al. 2019

Environ. Sci. Technol.

894

364

View full text Add to dashboard Cite

On account of environmental concerns, the fate and adverse effects of plastics have attracted considerable interest in the past few years. Recent studies have indicated the potential for fragmentation of plastic materials into nanoparticles, i.e., "nanoplastics," and their possible accumulation in the environment. Nanoparticles can show markedly different chemical and physical properties than their bulk material form. Therefore possible risks and hazards to the environment need to be considered and addressed. However, the fate and effect of nanoplastics in the (aquatic) environment has so far been little explored. In this review, we aim to provide an overview of the literature on this emerging topic, with an emphasis on the reported impacts of nanoplastics on human health, including the challenges involved in detecting plastics in a biological environment. We first discuss the possible sources of nanoplastics and their fates and effects in the environment and then describe the possible entry routes of these particles into the human body, as well as their uptake mechanisms at the cellular level. Since the potential risks of environmental nanoplastics to humans have not yet been extensively studied, we focus on studies demonstrating cell responses induced by polystyrene nanoparticles. In particular, the influence of particle size and surface chemistry are discussed, in order to understand the possible risks of nanoplastics for humans and provide recommendations for future studies.

show abstract

“…[160] In the celomic fluid of sea urchins, the twosome precursor protein has been identified as a dominant component in protein corona formed on NH 2 −PS NPs, triggering the interaction between the NH 2 −PS NPs and the sea urchin immune system cells (i.e., coelomocytes). [209] Likewise, protein corona on TiO 2 NPs formed in the celomic fluid of sea urchins have been found to contain many proteins involved in cellular adhesion, cytoskeletal organization, and immune response. [210]…”

Section: Immunotoxicitymentioning

confidence: 99%

The Crucial Role of Environmental Coronas in Determining the Biological Effects of Engineered Nanomaterials

Wang

et al. 2020

Small

View full text Add to dashboard Cite

In aquatic environments, a large number of ecological macromolecules (e.g., natural organic matter (NOM), extracellular polymeric substances (EPS), and proteins) can adsorb onto the surface of engineered nanomaterials (ENMs) to form a unique environmental corona. The presence of environmental corona as an eco–nano interface can significantly alter the bioavailability, biocompatibility, and toxicity of pristine ENMs to aquatic organisms. However, as an emerging field, research on the impact of the environmental corona on the fate and behavior of ENMs in aquatic environments is still in its infancy. To promote a deeper understanding of its importance in driving or moderating ENM toxicity, this study systemically recapitulates the literature of representative types of macromolecules that are adsorbed onto ENMs; these constitute the environmental corona, including NOM, EPS, proteins, and surfactants. Next, the ecotoxicological effects of environmental corona‐coated ENMs on representative aquatic organisms at different trophic levels are discussed in comparison to pristine ENMs, based on the reported studies. According to this analysis, molecular mechanisms triggered by pristine and environmental corona‐coated ENMs are compared, including membrane adhesion, membrane damage, cellular internalization, oxidative stress, immunotoxicity, genotoxicity, and reproductive toxicity. Finally, current knowledge gaps and challenges in this field are discussed from the ecotoxicology perspective.

show abstract

Cationic polystyrene nanoparticle and the sea urchin immune system: biocorona formation, cell toxicity, and multixenobiotic resistance phenotype

Cited by 71 publications

References 120 publications

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Emergence of Nanoplastic in the Environment and Possible Impact on Human Health

The Crucial Role of Environmental Coronas in Determining the Biological Effects of Engineered Nanomaterials

Contact Info

Product

Resources

About