Cationic β-cyclodextrin derivative for chiral separations

Haynes, Judson L.; Shamsi, Shahab A.; O'Keefe, Frank; Darcey, Raphel; Warner, Isiah M.

doi:10.1016/s0021-9673(97)01212-0

Cited by 60 publications

(40 citation statements)

References 58 publications

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“…Haynes et al prepared a new hepta-substituted single isomer cationic b-CD (heptakis (6-methoxyethylamine-6-deoxy)-b-CD [360] and checked its separation behavior towards NSAIDs and phenoxypropionic acid herbicides. Galaverna et al recently introduced histamine-modified cationic b-cyclodextrins as chiral selectors and demonstrated their applicability to chiral separation by means of Dns-amino acids, carboxylic acids and hydroxy acids [361].…”

Section: Neutral CD Derivatives a Great Variety Of Neutral Derivativmentioning

confidence: 99%

Chiral separation by chromatographic and electromigration techniques. A Review

Gübitz

Schmid

2001

Biopharm & Drug Disp

227

135

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This review gives a survey of different chiral separation principles and their use in high-performance liquid chromatography (HPLC), gas chromatography (GC), supercritical fluid chromatography (SFC), thin-layer chromatography (TLC), capillary electrophoresis (CE) and capillary electrochromatography (CEC) highlighting new developments and innovative techniques. The mechanisms of the different separation principles are briefly discussed and some selected applications are shown.

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Section: Neutral CD Derivatives a Great Variety Of Neutral Derivativmentioning

confidence: 99%

Chiral separation by chromatographic and electromigration techniques. A Review

Gübitz

Schmid

2001

Biopharm & Drug Disp

227

135

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“…One of the faster migrating antipodes of 2(2,4,5-TCPPA) co-eluted with one slower antipode of 2(2,4-DCPPA) while both baseline separation was obtained run separately ( Fig. 3-2) (Haynes et al, 1998). DCPP and imazaquin was analyzed by CE as an anion (Jarman et al, 2005).…”

Section: Separation Of Chiral Herbicides By Cementioning

confidence: 99%

“…1,1'=2-PPA, 2,2'=2,4-CPPA, 3,3'=2(2,4-DCPPA), 4,4'=2,2-CPPA, 5,5'=2,3-CPPA, 6,6'=2(2,4,5-TCPPA). (Haynes et al, 1998) …”

Section: Separation Of Chiral Herbicides By Cementioning

confidence: 99%

Enantioseparation and Enantioselective Analysis of Chiral Herbicides

Jin¹,

Gao²,

Li³

et al. 2011

Herbicides, Theory and Applications

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“…Besides the oftenused neutral CDs, the use of charged CD derivatives has expanded the range of applicability of this technique for chiral analysis [6]. The growing use of charged CDs for the enantioseparation of a wide range of enantiomers can be attributed to three important facts: (i) their ability to perform fast chiral separations at low concentrations; (ii) the possible chiral separation of neutral and charged racemates; and (iii) the effect that the introduction of ionogenic groups on the CD rim, or connected to it via a short alkyl chain, has on the enhancement of the solubility of charged CDs in aqueous media [7,8]. In addition, the enantioseparation of neutral analytes, which can be performed using charged micelles mixed with neutral CDs, can be carried out using charged CDs, which confers a nonzero mobility, without micelles.…”

Section: Introductionmentioning

confidence: 99%

Comparison of charged cyclodextrin derivatives for the chiral separation of atropisomeric polychlorinated biphenyls by capillary electrophoresis

2003

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Comparison of charged cyclodextrin derivatives for the chiral separation of atropisomeric polychlorinated biphenyls by capillary electrophoresisCharged cyclodextrin (CD) derivatives were used as chiral selectors in electrokinetic chromatography (EKC) for the chiral separation of highly hydrophobic neutral racemates such as atropisomeric polychlorinated biphenyls (PCBs). b-CD-phosphated, b-CD sulfated, succinylated-g-CD (Succ-g-CD) and succinylated-b-CD (Succ-b-CD) were used as anionic CDs. As cationic CD, 6-monodeoxy-6-monoamino-b-CD (b-CD-NH 2 ) was tested for the first time in order to separate PCBs. From the different CD derivatives employed, the best separations were obtained with the cationic CD derivative. Thus, the use of b-CD-NH 2 in phosphate buffer at pH 2.0 containing urea allowed the chiral recognition of eleven PCBs (45, 84, 88, 91, 95, 131, 136, 144, 149, 176, and 197). In this case, the addition of 2 M urea to the buffer solution was crucial to achieve the chiral separation of PCBs. The addition of acetonitrile to 10 mM phosphate buffer (pH 2.0) with 30 mM b-CD-NH 2 and 2 M urea improved considerably the chiral resolution obtained for PCBs 91, 95, 136, 144, 149, and 197 although an increase in the analysis time was also observed. All the results obtained were compared with those previously obtained with the dual CD system carboxymethyl-g-CD/b-CD.

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Cationic β-cyclodextrin derivative for chiral separations

Cited by 60 publications

References 58 publications

Chiral separation by chromatographic and electromigration techniques. A Review

Chiral separation by chromatographic and electromigration techniques. A Review

Enantioseparation and Enantioselective Analysis of Chiral Herbicides

Comparison of charged cyclodextrin derivatives for the chiral separation of atropisomeric polychlorinated biphenyls by capillary electrophoresis

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