Caudovirales bacteriophages are associated with improved executive function and memory in flies, mice, and humans

Mayneris‐Perxachs, Jordi; Castells-Nobau, Anna; Arnoriaga-Rodríguez, María; Garré-Olmo, Josep; Puig, Josep; Ramos, Rafael; Martínez-Hernández, Francisco; Burokas, Aurelijus; Coll, Clàudia; Moreno-Navarrete, José María; Zapata-Tona, Cristina; Pedraza, Salvador; Pérez‐Brocal, Vicente; Ramió-Torrentà, Lluı́s; Ricart, Wifredo; Moya, Andrés; Martínez‐García, Manuel; Maldonado, Rafaël; Fernández‐Real, José‐Manuel

doi:10.1016/j.chom.2022.01.013

Cited by 74 publications

(50 citation statements)

References 89 publications

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“…37 Phages of Siphoviridae are positively associated with cognition. 37 Reduction in phages SV and Lp Lj771 (Figure 2(b)) suggest the possible association with post-stroke cognitive dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, a recent study showed that phage supplementation with Lactococcal 936 bacteriophage increases memory in flies, and Caudovirales enriched fecal microbiota transplantation in mice increased memory. 37 Phages of Siphoviridae are positively associated with cognition. 37 Reduction in phages SV and Lp Lj771 (Figure 2(b)) suggest the possible association with post-stroke cognitive dysfunction.…”

Section: Discussionmentioning

confidence: 99%

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Gut virome dysbiosis following focal cerebral ischemia in mice

Chelluboina

Kieft

Breister

et al. 2022

J Cereb Blood Flow Metab

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Stroke leads to gut bacterial dysbiosis that impacts the post-stroke outcome. The gut microbiome also contains a high abundance of viruses which might play a crucial role in disease progression and recovery by modulating the metabolism of both host and host’s gut bacteria. We presently analyzed the virome composition (viruses and phages) by shotgun metagenomics in the fecal samples obtained at 1 day of reperfusion following transient focal ischemia in adult mice. Viral genomes, viral auxiliary metabolic genes, and viral protein networks were compared between stroke and sham conditions (stroke vs sham, exclusive to sham and exclusive to stroke). Following focal ischemia, abundances of 2 viral taxa decreased, and 5 viral taxa increased compared with the sham. Furthermore, the abundance of Clostridia-like phages and Erysipelatoclostridiaceae-like phages were altered in the stroke compared with the sham cohorts. This is the first report to show that the gut virome responds acutely to stroke.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gut virome dysbiosis following focal cerebral ischemia in mice

Chelluboina

Kieft

Breister

et al. 2022

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

show abstract

“…Perpetuating the coevolution with the bacteria and forming an interconnected network with the microorganisms in the intestine, phages have the potential to perform functions in the intestine 43 . With the focus on the gut virome‐disease associations increasing, phages are proved to be able to alter the gut microbiome structure by infecting the specific bacteria and then affect the gut microbiome function to cause the dysbiosis 48 . Lim et al found that there was an inverse correlation of bacteria and phage richness in the infant gut microbiome 49 .…”

Section: Discussionmentioning

confidence: 99%

“…43 With the focus on the gut virome-disease associations increasing, phages are proved to be able to alter the gut microbiome structure by infecting the specific bacteria and then affect the gut microbiome function to cause the dysbiosis. 48 Lim et al found that there was an inverse correlation of bacteria and phage richness in the infant gut microbiome. 49 Bacterial functions are correlated with the gut virome, predominantly Caudovirales and Microviridae in this study.…”

Section: Identification and Phylogenetic Analysis Of The Family Astro...mentioning

confidence: 99%

Dynamic alterations of the mice gut virome after Coxsackievirus B3 infection

Bao

Wang

et al. 2022

Journal of Medical Virology

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The gut microbiome plays an essential role in the human health and dysbiosis has been implicated in numerous diseases. Coxsackievirus B3 infects millions of humans yearly and yet limited research has explored dynamic alterations of the gut virome after infection. Here, we established the mouse model of Coxsackievirus B3 infection and collected fecal samples at several time points to investigate alterations of the gut virome using viral metagenomic analysis. We found that the mice virome was dominated by Caudovirales and Microviridae, and phylogenetic analyses showed that both Caudovirales and Microviridae had high diversity. The gut virome had significant variations with the increase of Caudovirales and the decrease of Microviridae after infection. We proposed that Caudovirales and Microviridae may be biomarkers for the Coxsackievirus infection process. This study provides a reference for the dynamic changes of the gut virome after human Enterovirus infection, which may help guide the rational drug use in clinical treatment and provide new ideas for preventing Enterovirus infection.

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“…Recent work has even begun to probe potential relationships between gut bacteriophage populations and cognition. Shotgun metagenomics of the fecal virome recently revealed a positive association between specific Caudovirales levels and parameters of executive function and memory [42 ▪ ].…”

Section: The Healthy Human Virome – Influence Of Diet Ethnicity and A...mentioning

confidence: 99%

The gut virome in health and disease: new insights and associations

Shareefdeen

Hill

2022

Current Opinion in Gastroenterology

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Purpose of reviewRecent years have seen great strides made in the field of viral metagenomics. Many studies have reported alterations in the virome in different disease states. The vast majority of the human intestinal virome consists of bacteriophages, viruses that infect bacteria. The dynamic relationship between gut bacterial populations and bacteriophages is influenced by environmental factors that also impact host health and disease. In this review, we focus on studies highlighting the dynamics of the gut virome and fluctuations associated with disease states.Recent findingsNovel correlations have been identified between the human gut virome and diseases such as obesity, necrotizing enterocolitis and severe acute respiratory syndrome coronavirus 2 infection. Further associations between the virome and cognition, diet and geography highlight the complexity of factors that can influence the dynamic relationship between gut bacteria, bacteriophages and health.SummaryHere, we highlight some novel associations between the virome and health that will be the foundation for future studies in this field. The future development of microbiome-based interventions, identification of biomarkers, and novel therapeutics will require a thorough understanding of the gut virome and its dynamics.

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Caudovirales bacteriophages are associated with improved executive function and memory in flies, mice, and humans

Cited by 74 publications

References 89 publications

Gut virome dysbiosis following focal cerebral ischemia in mice

Gut virome dysbiosis following focal cerebral ischemia in mice

Dynamic alterations of the mice gut virome after Coxsackievirus B3 infection

The gut virome in health and disease: new insights and associations

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