Causal Associations Between Educational Attainment and 14 Urological and Reproductive Health Outcomes: A Mendelian Randomization Study

Wang, Menghua; Jian, Zhongyu; Gao, Xiaoshuai; Chi, Yuan; Jin, Xi; Li, Hong; Wang, Kunjie

doi:10.3389/fpubh.2021.742952

Cited by 16 publications

(11 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By employing several Mendelian tools, the results were proved reliable for achieving stability in the sensitivity analysis. In previous MR studies, the casual effects of insomnia ( 39 ), snoring ( 40 ), educational attainment ( 41 ), and COVID-19 ( 42 ) on risk of ED have been sufficiently investigated.…”

Section: Discussionmentioning

confidence: 99%

Causal effects of hypertension on risk of erectile dysfunction: A two-sample Mendelian randomization study

Wang

Xiong

et al. 2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

BackgroundErection dysfunction has been associated with hypertension in several epidemiological and observational studies. But the causal association between hypertension and erectile dysfunction requires further investigation.MethodsA two-sample Mendelian randomization (MR) was conducted to analyze the causal effect of hypertension on risk of erection dysfunction. Large-scale publicly available genome-wide association study data were used to estimate the putative causality between hypertension and risk of erectile dysfunction. A total of 67 independent single nucleotide polymorphisms were selected as instrumental variables. Inverse-variant weighted, maximum likelihood, weighted median, penalized weighted median, and MR-PRESSO approaches were utilized in MR analyses. Heterogeneity test, horizontal pleiotropy test, and leave-one-out method were used to prove the stability of the results.ResultsIn total, all P values were less than 0.05, demonstrating a positive causal link between hypertension and risk of erectile dysfunction in multiple MR methods, such as inverse-variant weighted (random and fixed effect) (OR 3.8315, 95% CI 2.3004–6.3817, P = 0.0085), maximum likelihood (OR 3.8877, 95% CI 2.3224–6.5081, P = 0.0085), weighted median (OR 4.9720, 95% CI 2.3645–10.4550, P = 0.0309), penalized weighted median (OR 4.9760, 95% CI 2.3201–10.6721, P = 0.0355), and MR-PRESSO (OR 3.6185, 95% CI 2.2387–5.8488, P = 0.0092). Sensitivity analysis detected no evidence of heterogeneity, pleiotropy, or outlier single nucleotide polymorphisms.ConclusionThe study revealed a positive causal link between the presence of hypertension and the risk of erectile dysfunction. More attention should be paid during the management of hypertension with the purpose of preventing erectile dysfunction or improving erectile function.

show abstract

Section: Discussionmentioning

confidence: 99%

Causal effects of hypertension on risk of erectile dysfunction: A two-sample Mendelian randomization study

Wang

Xiong

et al. 2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…IVs were selected whose F > 10. After harmonizing the SNPs in the data source by effector alleles [26] , we discoveryed each instrument SNP in the PhenoScanner GWAS database [27] to assess any prior association (P < 5×10 − 8) with possible confounding factors (that is Body mass index and Cardiovascular diseases other than the current study diseases) [28][29][30] to avoid potential confounding. Finally, the SNPs left were selected as IVs for the following MR test.…”

Section: Selection Of Genetic Variantsmentioning

confidence: 99%

Effects of heart failure and coronary artery disease on erectile dysfunction: a two-sample Mendelian randomization study

Shao

Chen

et al. 2023

Preprint

View full text Add to dashboard Cite

Background and Aims: There are no clear conclusions as to whether heart failure (HF) and coronary heart disease (CAD) increase the risk of erectile dysfunction (ED).In our study, we used Mendelian randomization (MR) analysis to discover a causal relationship between HF, CAD and ED. Methods: Single nucleotide polymorphisms (SNPs) associated with HF, CAD and ED were obtained from the MRC IEU Open Genome-Wide Association Study (GWAS) database.After a series of screenings, the remaining SNPs were selected as instrumental variables (IVs) for HF and CAD for MR analysis to assess the relationship between genetically predicted HF or CAD and the pathogenesis of ED.Among them, we used the random-effects inverse variance weighted (IVW) method as the primary analysis method.Finally, Cochran's q-test, funnel plots, MR-Egger regression, Leave-one-out method and MR-PRESSO were used for sensitivity analysis. Results: In the IVW method, there was no significant causal relationship between genetically predicted HF and CAD and the incidence of ED.(HF: OR = 1.17, 95% CI 0.99-1.39; p = 0.074;CAD: OR = 1.08, 95% CI 0.99-1.17, p = 0.068)。The results of sensitivity analyses supported our conclusion that no horizontal pleiotropism was found. Conclusion: This study did not find a causal relationship between HF or CAD and ED in European populations, which requires further in-depth research.

show abstract

“…Mendelian Randomization (MR), a statistical method that mimics natural randomized controlled trials using single nucleotide polymorphisms (SNPs) as instrumental variables(IV), It is widely employed to investigate the causal relationships between various conditions 16 . Previous MR studies have a rmed a correlation between educational attainment and a reduced risk of female infertility 17,18 . However, these studies primarily concentrated on the total number of years of education completed by participants, lacking segmentation based on factors such as age at completion of full-time education, college completion, and speci c years of education.…”

Section: Introductionmentioning

confidence: 97%

Education, socioeconomic status, leisure sedentary behaviours and female infertility: Mendelian randomization study

qu,

huang,

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: Growing evidence suggests that education, socioeconomic status, and leisure sedentary behaviors are associated with female infertility. However, it remains uncertain whether these connections are causally related. Methods: Genetic variants from genome-wide association studies (GWAS) of education, socioeconomic status, and leisure sedentary behaviors were obtained from the UK Biobank and EBI database. Summarized GWAS data of female infertility were also acquired from the FinnGen Biobank Analysis. Univariable and multivariable MR analyses were performed to explore the relationships between education, socioeconomic status, leisure sedentary behaviors and female infertility. The primary analysis utilized inverse variance weighting, while alternative Mendelian Randomization (MR) methods such as MR-Egger, weighted median, and weighted mode estimate, along with Cochrane’s Q test, MR-Egger intercept test, MR pleiotropy residual sum and outliers (MR-PRESSO) test, and leave-one-out analysis were employed to evaluate sensitivity and heterogeneity. Results: The results of the univariate MR analysis indicated that age of full- time education had a protective effect on female infertility (odds ratio [OR] 0.471; 95% confidence interval [CI] 0.24 to 0.93; p = 0.03). However, no causal correlation was found between educational attainment (college completion and years of education), socioeconomic status (job involving heavy manual or physical work, average total household income before tax, and Townsend deprivation index at recruitment), leisure sedentary behaviors (leisure social activities at pubs or social clubs, time spent driving, time spent using a computer, and time spent watching television) and female infertility. Multivariable MR and reverse MR studies did not support the existence of a relationship between education, socioeconomic status, leisure sedentary behaviours and female infertility. No significant heterogeneity or horizontal pleiotropy was detected, and the stability of the results was confirmed through sensitivity analysis and the leave-one-out test. Conclusions: Age at completion of full-time education may be causally related to a reduced risk of female infertility.

show abstract

Causal Associations Between Educational Attainment and 14 Urological and Reproductive Health Outcomes: A Mendelian Randomization Study

Cited by 16 publications

References 34 publications

Causal effects of hypertension on risk of erectile dysfunction: A two-sample Mendelian randomization study

Causal effects of hypertension on risk of erectile dysfunction: A two-sample Mendelian randomization study

Effects of heart failure and coronary artery disease on erectile dysfunction: a two-sample Mendelian randomization study

Education, socioeconomic status, leisure sedentary behaviours and female infertility: Mendelian randomization study

Contact Info

Product

Resources

About