Causal interactions in resting-state networks predict perceived loneliness

Tian, Yin; Li, Yahui; Chen, Sifan; Guo, Daqing; Ding, Zechao; Tam, Kin Yip; Yao, Dezhong

doi:10.1371/journal.pone.0177443

Cited by 37 publications

(35 citation statements)

References 58 publications

(89 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The causal connection such as Granger causality analysis (GCA) reflected the directional flow of information between brain regions [15]. The causal relationship and adjustment patterns between different activation regions could be observed using GCA, which provided new insights for ADHD.…”

Section: Introductionmentioning

confidence: 99%

Causal connectivity abnormalities of regional homogeneity in children with attention deficit hyperactivity disorder: a rest-state fMRI study

Zhao

Zheng

et al. 2017

ADMET DMPK

Self Cite

View full text Add to dashboard Cite

<p class="ADMETabstracttext">The present study aimed to investigate individual differences of causal connectivity between brain regions in attention deficit hyperactivity disorder (ADHD) which was a psychiatric disorder. Resting-state functional magnetic resonance imaging (R-fMRI) data of typically-developing controls (TDC) children group and combined ADHD (ADHD-C) children group were distinguished by the support vector machine (SVM) with linear kernel function, based on regional homogeneity (ReHo), amplitude of low frequency fluctuation (ALFF) and fractional ALFF (FALFF). The highest classification accuracy yielded by ReHo was 90.91 %. Furthermore, the granger causality analysis (GCA) method based on the classified weight map of regions of interesting (ROIs) showed that five causal flows existed significant difference between TDC and ADHD-C. That is, the averaged GCA values of three causal connections (i.e. left VLPFC à left CC1, right PoCG à left CC1, and right PoCG à right CC2) for ADHD-C were separately stronger than those for TDC. And the other two connections (i.e. right FEF à right SOG and right CC1 à right SOG) were weaker for ADHD-C than those for TDC. In addition, only two causality flows (i.e. left VLPFC à left CC1 and right PoCG à right CC2) presented that their GCA values were positively correlation with ADHD index scores, respectively. Our findings revealed that ADHD children represented widespread abnormalities in the causality connectivity, especially involved in the attention and memory related regions. And further provided evidence that the potential neural causality flows could play a key role in characterizing individual’s ADHD.</p>

show abstract

Section: Introductionmentioning

confidence: 99%

Causal connectivity abnormalities of regional homogeneity in children with attention deficit hyperactivity disorder: a rest-state fMRI study

Zhao

Zheng

et al. 2017

ADMET DMPK

Self Cite

View full text Add to dashboard Cite

show abstract

“…Some researchers revealed that the parahippocampal cortex and hippocampus were involved in memory [10][11][12][13]. The parahippocampal cortex played a role for spatial configuration of object in memory [14].…”

Section: Resultsmentioning

confidence: 99%

Identify the radiotherapy-induced abnormal changes in the patients with nasopharyngeal carcinoma

Wang

Zhao

Zhang³

et al. 2017

ADMET DMPK

Self Cite

View full text Add to dashboard Cite

<p class="ADMETabstracttext">Radiotherapy (RT) is the standard treatment for nasopharyngeal carcinoma, which often causes inevitable brain injury in the process of treatment. The majority of patients has no abnormal signal or density change of the conventional magnetic resonance imaging (MRI) and computed tomography (CT) examination in the long-term follow-up after radiation therapy. However, when there is a visible CT and conventional MR imaging changes, the damage often has been severe and lack of effective treatments, seriously influencing the prognosis of patients. Therefore, the present study aimed to investigate the abnormal changes in nasopharyngeal carcinoma (NPC) patients after RT. In the present study, we exploited the machine learning framework which contained two parts: feature extraction and classification to automatically detect the brain injury. Our results showed that the method could effectively identify the abnormal regions reduced by radiotherapy. The highest classification accuracy was 82.5 % in the abnormal brain regions. The parahippocampal gyrus was the highest accuracy region, which suggested that the parahippocampal gyrus could be most sensitive to radiotherapy and involved in the pathogenesis of radiotherapy-induced brain injury in NPC patients.</p>

show abstract

“…It suggests that loneliness affects regions involved in social cognitions and empathy as well as emotional regulation. Perceived loneliness was predicted by effective connectivity of affective network to visual network and dorsal attentional network to ventral attentional network (Tian et al, ).…”

Section: Neuroimaging Of Social Exclusion and Lonelinessmentioning

confidence: 99%

Interest of neuroimaging of social exclusion in suicide

Olié

Courtet

2018

J of Neuroscience Research

View full text Add to dashboard Cite

With one million deaths worldwide, suicide is a major health issue. The frequency of life events preceding suicidal act is high and raises the question of their role in suicidal process. At biological level, dysfunctional neural processing of social exclusion may participate in suicidal risk through an increased perception of social adversity in vulnerable subjects. The purpose of this narrative review is to discuss neuroimaging findings related to social exclusion and loneliness, and to open new perspectives to investigate sensitivity to social stress in suicide.

show abstract

Causal interactions in resting-state networks predict perceived loneliness

Cited by 37 publications

References 58 publications

Causal connectivity abnormalities of regional homogeneity in children with attention deficit hyperactivity disorder: a rest-state fMRI study

Causal connectivity abnormalities of regional homogeneity in children with attention deficit hyperactivity disorder: a rest-state fMRI study

Identify the radiotherapy-induced abnormal changes in the patients with nasopharyngeal carcinoma

Interest of neuroimaging of social exclusion in suicide

Contact Info

Product

Resources

About