Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits

Ducrocq, Fabien; Walle, Roman; Contini, Andrea; Oummadi, Asma; Caraballo, Baptiste; Veldt, Suzanne van der; Boyer, Marie-Lou; Aby, Frank; Tolentino-Cortez, Tarson; Helbling, Jean‐Christophe; Martine, Lucy; Grégoire, Stéphane; Cabaret, Stéphanie; Vancassel, Sylvie; Layé, Sophie; Kang, Jing; Fioramonti, Xavier; Berdeaux, Olivier; Barreda-Gómez, Gabriel; Masson, Elodie; Ferreira, Guillaume; W.L., David; Bosch‐Bouju, Clémentine; Smedt-Peyrusse, Véronique de; Trifilieff, Pierre

doi:10.1016/j.cmet.2020.02.012

Cited by 39 publications

(23 citation statements)

References 128 publications

(168 reference statements)

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“…Knowing the major importance of the brain in regulating food intake, this study was the first step which enable to understand the alteration of growth performance of trout fed with 100% plant based-diet devoid of u-3 LC-PUFAs. In this way, recent study demonstrated a causal link between a behavioral deficit and u-3 LC-PUFAs decrease in a discrete brain cell population suggesting that lower u-3 LC-PUFAs biostatus could participate in the etiology of reward-related symptoms and then could influence food-reward [50]. This study demonstrated that all juveniles reached the same final body weight, with no differences in growth parameters (Table 3).…”

Section: Discussionsupporting

confidence: 62%

Characterization and modulation of brain lipids content of rainbow trout fed with 100% plant based diet rich in omega-3 long chain polyunsaturated fatty acids DHA and EPA

et al. 2020

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Section: Discussionsupporting

confidence: 62%

Characterization and modulation of brain lipids content of rainbow trout fed with 100% plant based diet rich in omega-3 long chain polyunsaturated fatty acids DHA and EPA

et al. 2020

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“…During thawing, samples were treated with protease inhibitors (Complet ultra tablet, Roche Diagnostics, Meylan, France) and buffered with NaOH 1 mol/L to adjust the acidic pH of the extraction buffer. Then, equal quantities of proteins were electrophoresed on 12% sodium polyacrylamide-dodecyl sulfate gel with a 4% stacking gel and transferred to nitrocellulose membranes (Amersham 300 × 4 mm, UGAP, Champssur-Marne, France) as previously described [53]. Membranes were saturated 1 h in 5% milk (Regilait, UGAP, Champs-sur-Marne, France) or 5% BSA (P06-139,1100, Dutscher, Montsaunès, France) in Tris-Buffered Saline (TBS) and Tween 0.1%, then incubated with different primary antibodies overnight at 4 • C: anti-DRD1 (D2944; Sigma, Molsheim, France), anti-DRD2, anti-DAT (AB5084P, AB2231 respectively; Millipore, Molsheim, France), anti-SERT, anti-5-HTR1a (ab172884, ab85615 respectively; Abcam, Cambridge, UK) and anti-GAPDH (glyceraldehyde 3-phosphate dehydrogenase) as maintenance protein (5174S, rabbit; Cell Signaling, Leiden, The Netherlands).…”

Section: Western Blotting (Wb)mentioning

confidence: 99%

Prevention of Stress-Induced Depressive-like Behavior by Saffron Extract Is Associated with Modulation of Kynurenine Pathway and Monoamine Neurotransmission

et al. 2021

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Depressive disorders are a major public health concern. Despite currently available treatment options, their prevalence steadily increases, and a high rate of therapeutic failure is often reported, together with important antidepressant-related side effects. This highlights the need to improve existing therapeutic strategies, including by using nutritional interventions. In that context, saffron recently received particular attention for its beneficial effects on mood, although the underlying mechanisms are poorly understood. This study investigated in mice the impact of a saffron extract (Safr’Inside™; 6.25 mg/kg, per os) on acute restraint stress (ARS)-induced depressive-like behavior and related neurobiological alterations, by focusing on hypothalamic–pituitary–adrenal axis, inflammation-related metabolic pathways, and monoaminergic systems, all known to be altered by stress and involved in depressive disorder pathophysiology. When given before stress onset, Safr’Inside administration attenuated ARS-induced depressive-like behavior in the forced swim test. Importantly, it concomitantly reversed several stress-induced monoamine dysregulations and modulated the expression of key enzymes of the kynurenine pathway, likely reducing kynurenine-related neurotoxicity. These results show that saffron pretreatment prevents the development of stress-induced depressive symptoms and improves our understanding about the underlying mechanisms, which is a central issue to validate the therapeutic relevance of nutritional interventions with saffron in depressed patients.

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“…The antagonistic effects of D1-and D2-MSNs of the NAc in the modulation of motivational processes in the context of food-seeking behavior have been recently challenged. Here, we found that chemogenetic activation or inhibition of D2-MSNs did not impact licking patterns during consumption of a palatable solution (SF2), a proxy for hedonic reactivity (Johnson, 2018a;Ducrocq et al, 2019Ducrocq et al, , 2020, but decreased and increased performance in a progressive ratio task, respectively (Figure 2A-D; SF2), without alteration in motoric abilities (Figure 2E, SF2), supporting an "amotivational" effect of D2-MSNs of the NAc core.…”

Section: D1-msns and D2-msns Of The Nac Core Respectively Facilitate ...mentioning

confidence: 62%

“…Bursts were defined as sequences of high frequency licks, in which the interlick interval was less than 250ms. Relation between number of licks per burst and hedonic reactivity have been demonstrated in (Ducrocq et al, 2020;Johnson, 2018b;Ward et al, 2012).…”

Section: Licking Microstructuresmentioning

confidence: 99%

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Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure

Walle

Petitbon

Fois

et al. 2022

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Obesity-related pathologies and anorexia nervosa are increasingly considered as opposite ends of eating disorders (ED) spectrum. Accordingly, accumulating evidence points to opposite dysregulations of common brain systems in these pathologies, the Nucleus Accumbens (NAc) in particular. However, to which extent alterations in NAc activity are sufficient to elicit ED-like behavioral dimensions remains to be established. Using acute, bidirectional, chemogenetic modulation of each NAc medium spiny neuron (MSN) subpopulation, we found that D1-MSNs and D2-MSNs oppositely regulate the balance between food intake and exercise-induced energy expenditure. As opposed to the limited effect of repeated chemogenetic manipulations of each MSN subpopulation, the concomitant manipulation of both MSN subpopulation had sustained effects. Repeated activation of D1-MSNs combined with repeated inhibition of D2-MSNs biased behavior toward activity-related energy expenditure leading to weight/fat loss, whilst the opposite manipulations favored energy intake and hence weight/fat gain. These results suggest that dysregulations of NAc dopaminoceptive MSN network might be at the core of EDs.

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Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits

Cited by 39 publications

References 128 publications

Characterization and modulation of brain lipids content of rainbow trout fed with 100% plant based diet rich in omega-3 long chain polyunsaturated fatty acids DHA and EPA

Characterization and modulation of brain lipids content of rainbow trout fed with 100% plant based diet rich in omega-3 long chain polyunsaturated fatty acids DHA and EPA

Prevention of Stress-Induced Depressive-like Behavior by Saffron Extract Is Associated with Modulation of Kynurenine Pathway and Monoamine Neurotransmission

Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure

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