Causal role of Helicobacter pylori infection in gastric cancer: An Asian enigma

Singh, Kartar; Ghoshal, Uday C

doi:10.3748/wjg.v12.i9.1346

Cited by 121 publications

(105 citation statements)

References 62 publications

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“…Pakistan is considered among the countries with a high rate of gastroduodenal pathologies, especially DU; however, unlike the East Asian rim, the frequency of GC is low [24]. Several studies reported the high rate of H. pylori infection in the country based on serological, bacteriological, and histological observations [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Prevalence, diversity and disease association of Helicobacter pylori in dyspeptic patients from Pakistan

Khan

Farooqui

Raza

et al. 2013

J Infect Dev Ctries

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Introduction: The etiological association of Helicobacter pylori with gastric ulcer (GU), gastric cancer (GC), and duodenal ulcer (DU) is well-known. Understanding the epidemiology of H. pylori facilitates the estimation of disease burden in a certain population. This study presents the diversity of H. pylori genotypes and their association with different clinical outcomes among dyspeptic patients in Pakistan over a period of four years. Methodology: Gastric biopsy samples from a total of 450 dyspeptic individualswere subjected to PCR, genotypingand histology. Results: A total of 201 (45%) cases were found positive for H. pylori. The detection rate was high in GU (91%), DU (86%) and GC (83%) cases compared with those cases who had intact gastric mucosa (18%). Histology revealed the presence of infection in 68% of cases of mild/chronic nonspecific gastritis with others belonging to the GU sequel. cagA gene carriage was observed in 104 (51%) cases or mostly from DU, GU and GC groups, of which 97 were Western type strains while 3 were East-Asian type strains that are rarely observed in South Asia. vacA allelic variant s1am1 was most commonly observed, followed by s1am2, and s1bm1, with direct correlation in diseased cases (gastritis, GU, DU and GC). Prevalent genotypic combinations were s1am1/cagA -in gastritis and s1am1/cagA + in DU, GU, and GC. Conclusions: Our study indicates the predominant circulation of Western type cagA and vacAs1am1 type H. pylori strains in Pakistan.

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Section: Introductionmentioning

confidence: 99%

Prevalence, diversity and disease association of Helicobacter pylori in dyspeptic patients from Pakistan

Khan

Farooqui

Raza

et al. 2013

J Infect Dev Ctries

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“…Almost 50% to 80% of the world's population infected with H.pylori, but only 1% of them developed gastric cancer (Graham et al, 1991;Parsonnet et al, 1997), which suggested the host genetic and environmental factors may modulate the risk of gastric cancer in association with H.pylori infection (Singh et al, 2006;Ghoshal et al, 2008;Ghoshal et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

SNPs of Excision Repair Cross Complementing Group 5 and Gastric Cancer Risk in Chinese Populations

Yang¹,

Zhang²,

Chen³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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We conducted a case-control study to determine the association between several potential SNPs of excision repair cross complementing group 5 (XPG) and gastric cancer susceptibility, and roles of XPG polymorphisms in combination with H.pylori infection in determining risk of gastric cancer. In our study, we collected 337 newly diagnosed gastric cancer cases and 347 health controls. Three SNPs of XPG, rs2296147T>C, rs2094258C>T and rs873601G>A, were genotyped using the Taqman real-time PCR method with a 7900 HT sequence detector system. H. pylori infection was diagnosed by ELISA. By multivariate logistic regression analysis, the rs2296147 CC genotype was associated with a decreased risk of gastric cancer (OR=0.52, 95% CI=0.27-0.97), and rs2094258 TT was associated with elevated risk (OR=2.13, 95% CI=1.22-3.35). Positive H.pylori individuals with rs2094258 TT genotypes demonstrated increased risk of gastric cancer (OR=2.13, 95% CI=1.22-3.35), while rs2296147 CC was associated with lower risk among patients with negative H.pylori (OR=0.45, 95%CI=0.22-0.89). Our findings suggested that XPG polymorphisms might contribute to risk of gastric cancer among Chinese populations, but the effect needs to be further validated by larger sample size studies.

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“…Although several meta-analyses revealed a strong relationship between H. pylori and gastric cancer (Eslick et al, 1999;Xue et al, 2001), it is still controversial in different Asian countries (Miwa et al, 2002;Jing et al, 2012). Various studies from India also failed to show an association between H. pylori infection and gastric cancer (Kate et al, 2000;Khanna et al, 2002;Singh et al, 2006). These disparate observations have created an enigmatic situation in Indian context and needs serious approach to solve this problem.…”

Section: Discussionmentioning

confidence: 99%

Genetic Polymorphism of Glutathione S-transferases M1 and T1, Tobacco Habits and Risk of Stomach Cancer in Mizoram, India

Malakar¹,

Devi²,

Phukan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Aim: The incidence of stomach cancer in Mizoram is highest in India. We have conducted a population based matched case-control study to identify environmental and genetic risk factors in this geographical area. Methods: A total of 102 histologically confirmed stomach cancer cases and 204 matched healthy population controls were recruited. GSTM1 and GSTT1 genotypes were determined by PCR and H. pylori infections were determined by ELISA. Results: Tobacco-smoking was found to be an important risk factor for high incidence of stomach cancer in Mizoram. Meiziol (local cigarette) smoking was a more important risk factor than other tobacco related habits. Cigarette, tuibur (tobacco smoke infused water) and betel nut consumption synergistically increased the risk of stomach cancer. Polymorphisms of GSTM1 and GSTT1 genes were not found to be directly associated with stomach cancer in Mizoram. However, they appeared to be effect modifiers. Persons habituated with tobacco smoking and/or tuibur habit had increased risk of stomach cancer if they carried the GSTM1 null genotype and GSTT1 non-null genotype. Conclusion: Tobacco smoking, especially meiziol is the important risk factor for stomach cancer in Mizoram. GSTM1 and GSTT1 genes modify the effect of tobacco habits. This study is a first step in understanding the epidemiology of stomach cancer in Mizoram, India.

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Causal role of Helicobacter pylori infection in gastric cancer: An Asian enigma

Cited by 121 publications

References 62 publications

Prevalence, diversity and disease association of Helicobacter pylori in dyspeptic patients from Pakistan

Prevalence, diversity and disease association of Helicobacter pylori in dyspeptic patients from Pakistan

SNPs of Excision Repair Cross Complementing Group 5 and Gastric Cancer Risk in Chinese Populations

Genetic Polymorphism of Glutathione S-transferases M1 and T1, Tobacco Habits and Risk of Stomach Cancer in Mizoram, India

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