Streaming feature selection has always been an excellent method for selecting the relevant subset of features from high-dimensional data and overcoming learning complexity. However, little attention is paid to online feature selection through the Markov Blanket (MB). Several studies based on traditional MB learning presented low prediction accuracy and used fewer datasets as the number of conditional independence tests is high and consumes more time. This paper presents a novel algorithm called Online Feature Selection Via Markov Blanket (OFSVMB) based on a statistical conditional independence test offering high accuracy and less computation time. It reduces the number of conditional independence tests and incorporates the online relevance and redundant analysis to check the relevancy between the upcoming feature and target variable T, discard the redundant features from Parents-Child (PC) and Spouses (SP) online, and find PC and SP simultaneously. The performance OFSVMB is compared with traditional MB learning algorithms including IAMB, STMB, HITON-MB, BAMB, and EEMB, and Streaming feature selection algorithms including OSFS, Alpha-investing, and SAOLA on 9 benchmark Bayesian Network (BN) datasets and 14 real-world datasets. For the performance evaluation, F1, precision, and recall measures are used with a significant level of 0.01 and 0.05 on benchmark BN and real-world datasets, including 12 classifiers keeping a significant level of 0.01. On benchmark BN datasets with 500 and 5000 sample sizes, OFSVMB achieved significant accuracy than IAMB, STMB, HITON-MB, BAMB, and EEMB in terms of F1, precision, recall, and running faster. It finds more accurate MB regardless of the size of the features set. In contrast, OFSVMB offers substantial improvements based on mean prediction accuracy regarding 12 classifiers with small and large sample sizes on real-world datasets than OSFS, Alpha-investing, and SAOLA but slower than OSFS, Alpha-investing, and SAOLA because these algorithms only find the PC set but not SP. Furthermore, the sensitivity analysis shows that OFSVMB is more accurate in selecting the optimal features.