Causative Microorganisms and Antibiotics Susceptibilities in Children with Urinary Tract Infection

Abstract

Generally, treatment of urinary tract infection (UTI) in children is a difficult task, due to development of high resistance against antibiotics. The object of this study is to investigate the greatest causative microorganisms, their susceptibility and resistance to antibiotics in children suffering from UTI in Baghdad. A total of 810 urine samples were collected from suspected cases of UTI in children patients of ages (1 day to 12 years) of both sexes. Urine specimens were examined by urinalysis and cultured for isolation of microbial agents. In this study, Bacterial growth was obtained in 202 samples (24.39%) out of 810 urine samples. Various pathogenic organisms were isolated, which represented by A) Gram-Negative bacilli include Escherichia coli (41.58%), Enterobacter spp. (13.68%), Proteus Mirabilis (12.78%), Acinetobacter spp. (4.45%), Providencia spp. (4.45%), Pseudomonas aeruginosa (3.46), Klebsiella pneumoniae (2.47%), Citrobacter spp.(0.49%), Salmonella Spp.(0.49%), B) Gram- Positive cocci: Staphylococcus aureus (11.38%), Enterococcus faecalis (1.98%) and Streptococcus agalactiae (1.48%) C) Candida albicans (0.9%).). According to antibiotic susceptibility test, mostly the isolates were resistant to Nalidixic acid (67.05%), cefotaxime (59.40%) and cefepime (50.49%). Mostly Gram-Negative bacilli were responsible for UTI, and maximum recurrent isolated bacteria were Escherichia coli. The isolated bacteria were found to be sensitive to Imipenem, Amikacin, and ciprofloxacin. Therefore, the selection of antibiotic therapy in UTI should depend on the native sensitivity form of the infecting organism.

Bacterial Profile and Antibiotic Susceptibility Patterns of Urinary Tract Infection Among Children in Karbala Teaching Hospital

“…In this study, the highest prevalence of UTI (46 %) was noted in those children aged under 1 year. This is consistent with two studies performed in Iraq [17] and Greece [18], in which the age groups with the highest frequency of UTI were less than 1 year (27.72%). The propensity for this age-group to acquire UTI may be related to underlying urinary tract anomalies, an impaired immune response or alternative concomitant conditions.…”