Causes and Consequences of Premature Rupture of Fetal Membranes

Naeye, Richard L.; Peters, Ellen C.

doi:10.1016/s0140-6736(80)90674-1

Cited by 204 publications

(96 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, cell degeneration noted in ruptured areas [12,4] may be limited to a rather small section of the tissue and may, perhaps, be attributed to certain cases of local infections [19,23]. The concentration of the cellular components, like cholesterol and phospho-lipids, were also not significantly different in the two groups of membranes, consistent with the DNA and RNA data.…”

Section: Discussionsupporting

confidence: 52%

Studies of normal and prematurely ruptured human amniotic membranes: Low calcium and magnesium in prematurely ruptured membranes

Kidroni¹,

Menczel²,

Ron³

1989

Jpme

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 52%

Studies of normal and prematurely ruptured human amniotic membranes: Low calcium and magnesium in prematurely ruptured membranes

Kidroni¹,

Menczel²,

Ron³

1989

Jpme

View full text Add to dashboard Cite

“…362 Several studies have identified an association of subclinical chorioamnionitis (ie, intact membranes) with spontaneous preterm labor. [363][364][365] Pathogens were identified from the amniotic fluid in 10% to 15% of cases presenting with preterm labor. 366 A meta-analysis by the Cochrane collaboration of available RCTs of antibiotic therapy in preterm labor with intact membranes 367 identified that antibiotic treatment in this situation prolonged pregnancy (weighted mean difference: 5.4 days; CI: 0.9 -9.8 days).…”

Section: Antibiotics For Preterm Labormentioning

confidence: 99%

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

et al. 2005

View full text Add to dashboard Cite

ABSTRACT. Background. Infant and under-5 childhood mortality rates in developing countries have declined significantly in the past 2 to 3 decades. However, 2 critical indicators, maternal and newborn mortality, have hardly changed. World leaders at the United Nations Millennium Summit in September 2000 agreed on a critical goal to reduce deaths of children <5 years by two thirds, but this may be unattainable without halving newborn deaths, which now comprise 40% of all under-5 deaths. Greater emphasis on wide-scale implementation of proven, cost-effective measures is required to save women's and newborns' lives. Approximately 99% of neonatal deaths take place in developing countries, mostly in homes and communities. A comprehensive review of the evidence base for impact of interventions on neonatal health and survival in developingcountry communities has not been reported.Objective. This review of community-based antenatal, intrapartum, and postnatal intervention trials in developing countries aimed to identify (1) key behaviors and interventions for which the weight of evidence is sufficient to recommend their inclusion in communitybased neonatal care programs and (2) key gaps in knowledge and priority areas for future research and program learning.Methods. Available published and unpublished data on the impact of community-based strategies and interventions on perinatal and neonatal health status outcomes were reviewed. Evidence was summarized systematically and categorized into 4 levels of evidence based on study size, location, design, and reported impact, particularly on perinatal or neonatal mortality. The evidence was placed in the context of biological plausibility of the intervention; evidence from relevant developed-country studies; health care program experience in implementation; and recommendations from the World Health Organization and other leading agencies.Results. A paucity of community-based data was found from developing-country studies on health status impact for many interventions currently being considered for inclusion in neonatal health programs. However, review of the evidence and consideration of the broader context of knowledge, experience, and recommendations regarding these interventions enabled us to categorize them according to the strength of the evidence base and confidence regarding their inclusion now in programs. This article identifies a package of priority interventions to include in programs and formulates research priorities for advancing the state of the art in neonatal health care.Conclusions. This review emphasizes some new findings while recommending an integrated approach to safe motherhood and newborn health. The results of this study provide a foundation for policies and programs related to maternal and newborn health and emphasizes the importance of health systems research and evaluation of interventions. The review offers compelling support for using research to identify the most effective measures to save newborn lives. It also may facilitate dialogue with policy...

show abstract

“…5 This is the reason why PPROM and chorioamnionitis frequently coexist. 6,7 Preterm premature rupture of membranes (PPROM), defined as spontaneous rupture of the membranes before 37 weeks of gestation, is the major identifiable cause of preterm delivery, 8,9 occurring approximately in one-third of all preterm births. 8 Multifactorial in nature, 5 PPROM, however, is most strongly associated with the presence of intrauterine infection/inflammation.…”

Section: Introductionmentioning

confidence: 99%

Preterm premature rupture of membranes, chorioamnion inflammatory scores and neonatal respiratory outcome

Zanardo¹,

Vedovato²,

Cosmi

et al. 2009

BJOG

View full text Add to dashboard Cite

Objective To evaluate whether histological chorioamnionitis (HCA), in the setting of preterm premature rupture of membranes (PPROM), affects infant respiratory outcome.Design A prospective histological study on 287 consecutive placentas was performed in preterm infants (£32 +6 weeks gestation), categorised into four groups: according to the presence or absence of HCA, in the setting or in absence of PPROM. Results Among the 287 NICU admitted preterm infants, 68/287 (23.6%) presented with HCA, 16/68 (23.5%) with a coexisting fetal inflammatory response, and 74/287 (25.7%) with PPROM. HCA was associated with a greater frequency of vaginal delivery (P < 0.0001), lower gestational age (P < 0.0001) and lower birth weight (P < 0.01). HCA had no effect on fetal lung maturation, however, it was a significant risk factor for CLD (RR; 95% CI 2.08; 1.30-3.33). HCA and the fetal inflammatory response were also significant risk factors for PPROM (RR; 95% CI 2.07; 1.42-3.03 and 2.64; 1.71-4.09 respectively). Conversely, HCA in the setting of PPROM failed to reveal any RDS protection or subtype CLD risk. Multivariate analysis demonstrated significant independent effects of presence of maternal HCA (P = 0.04), gestational age (P < 0.0001) and interaction HCA-gestational age (P = 0.04) on CLD development, regardless of the presence of fetal HCA or fetal HCA-gestational age interaction, PPROM or PPROM-gestational age interaction.Conclusions Histological chorioamnionitis is a significant PPROM and CLD risk factor, but it fails to provide any protection from RDS. HCA in the setting of PPROM also failed to reveal any RDS protection or subtype CLD risk.Keywords Chronic lung disease, fetal inflammatory response syndrome, histological chorioamnionitis, preterm premature rupture of membranes, respiratory distress syndrome.Please cite this paper as: Zanardo V, Vedovato S, Cosmi E, Litta P, Cavallin F, Trevisanuto D, Chiarelli S. Preterm premature rupture of membranes, chorioamnion inflammatory scores and neonatal respiratory outcome. BJOG 2010;117:94-98.

show abstract

Causes and Consequences of Premature Rupture of Fetal Membranes

Cited by 204 publications

References 5 publications

Studies of normal and prematurely ruptured human amniotic membranes: Low calcium and magnesium in prematurely ruptured membranes

Studies of normal and prematurely ruptured human amniotic membranes: Low calcium and magnesium in prematurely ruptured membranes

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

Preterm premature rupture of membranes, chorioamnion inflammatory scores and neonatal respiratory outcome

Contact Info

Product

Resources

About