Causes of childhood epilepsy in Vietnam: cases in Bach Mai Hospital

Shirasaka, Yukiyoshi; Hinh, Le Duc; Minh, Phan Hong; Sato, Wakiro

doi:10.1111/j.1442-200x.2007.02432.x

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Some children with CNS abnormalities die after birth ( 10 ), and those who survive may suffer from psychomotor developmental abnormalities. A study by Shirasaka et al, examining the causes of epilepsy in children treated at Bach Mai Hospital from 2002 to 2004, reported that congenital CNS abnormalities accounted for 12% of cases ( 11 ). The early and accurate detection of CNS abnormalities can provide clinicians with the necessary information to make a prognosis, perform prenatal counseling, and determine the most appropriate treatment after birth.…”

Section: Introductionmentioning

confidence: 99%

Detecting Fetal Central Nervous System Anomalies Using Magnetic Resonance Imaging and Ultrasound

Linh¹,

Duc²,

Nhung³

et al. 2021

Med Arch

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Background: Most fetal abnormalities can be detected on ultrasound, the evaluation of fetal CNS abnormalities can be limited by various factors, including obesity, polyhydramnios, multiple pregnancies, and increased cranial ossification during the third trimester. Objective: This study aimed to evaluate the ability to detect fetal central nervous system (CNS) anomalies using in utero magnetic resonance imaging (iuMRI) and ultrasound (US) techniques. Methods: This prospective study was approved by the institutional review board (Ref: 2968/QĐ-ĐHYHN dated 11 July 2019), and the requirement to obtain the informed consent of patients was waived. This study included 66 fetuses with diagnosed or suspected CNS abnormalities based on the results of a prenatal screening US performed at the antenatal diagnosis center of the Central Obstetrics and Gynecology Hospital. All pregnant women with a suspected diagnosis of abnormal fetal CNS on US underwent 1.5-Tesla iuMRI within 14 days of the US at Hanoi Medical University Hospital between June 2019 and June 2020. Cohen’s kappa coefficient (κ) was used to determine the agreement between US and iuMRI findings. Results: A total of 66 pregnant women were examined, including 66 fetuses, for which 79 abnormalities were detected by US and 98 abnormalities were detected by iuMRI. The average gestational age was 29 weeks and 6 days. The comparison of iuMRI and US findings revealed similar diagnoses for 71 abnormalities (67%) and different diagnoses for 35 abnormalities (33%). The level of agreement between US and iuMRI was almost perfect for ventriculomegaly and cystic lesions, with κ values 0.87 and 0.84, respectively. The level of agreement between US and iuMRI was the weakest for hemorrhage, with a κ value 0 (no agreement), and cortical abnormalities, with a κ value of 0.46 (weak agreement). Conclusion: The level of agreement between US and iuMRI diagnoses was almost perfect for the detection of ventriculomegaly and was weakest for the detection of hemorrhage and cortical abnormalities, which were abnormalities detected by iuMRI but not by ultrasound.

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Section: Introductionmentioning

confidence: 99%

Detecting Fetal Central Nervous System Anomalies Using Magnetic Resonance Imaging and Ultrasound

Linh¹,

Duc²,

Nhung³

et al. 2021

Med Arch

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“…Therefore, we assume that SCARs caused by CBZ and allopurinol in Vietnam might then be largely preventable, especially as genetic screening programs would likely be beneficial in view of the high prevalence of HLA-B*15:02 and HLA-B*58:01, similar to that in the Taiwanese and Thai populations 33, 34. Moreover, as Vietnam is a typical developing country with a high burden of disease requiring treatment with CBZ or allopurinol (epilepsy, mental disorders, pain syndromes and hyperuricemia),35, 36, 37, 38, 39 alternative medications to CBZ or allopurinol may be too costly. Taking epilepsy as an example, the treatment gap in Vietnam (defined as the proportion of patients who are not given appropriate treatment for active epilepsy) was reported at 84.7% (compared with 56% in other countries) 82 .…”

Section: Introductionmentioning

confidence: 99%

Developing pharmacogenetic screening methods for an emergent country: Vietnam

Nguyen¹,

Vidal²,

Chu³

et al. 2019

World Allergy Organization Journal

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Background The finding of strong associations between certain human leukocyte antigen (HLA) genotypes and the development of severe cutaneous adverse drug reactions (SCARs), [for example, HLA-B*57:01 and abacavir (ABC), HLA-B*15:02 and carbamazepine (CBZ) and HLA-B*58:01 and allopurinol], has led to HLA screening being used to prevent SCARs. Screening has been shown to be of great benefit in a number of studies. Clinical translation from bench to bedside, however, depends upon the development of simple, rapid and cost-effective assays to detect these risk alleles. In highly populated developing countries such as Vietnam, where there is a high prevalence of HLA-B*15:02 and HLA-B*58:01 correlating with a high incidence of CBZ- and allopurinol-induced SCARs, the crucial factor in the implementation of comprehensive screening programs to detect these major risk HLA alleles is the availability of suitable assays. Body We have summarized the role and economic benefits of HLA screening, reviewed published HLA screening methods used currently in pharmacogenetic screening and examined the advantages and disadvantages of assays developed specifically for use in screening for risk alleles in the prevention of HLA-associated SCARs in Vietnam. Conclusion The optimal approach we propose may serve as a template for the development of screening programs in other emergent countries.

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