Concerning the causes, the following were noted: (i) the rate of infectious diseases and trauma as causes of epilepsy was considerably higher in Vietnam than in developed countries; (ii) certain infectious diseases could be prevented if vaccinations and public health knowledge were improved; and (iii) the number of trauma cases, mainly due to traffic accidents, would likely be reduced if the traffic system was improved.

Background: HER2-positive breast cancer is a breast cancer that tests positive with human epidermal growth factor receptor 2 (HER2). Human Epidermal Growth Factor Receptor-2 (HER2) promotes the proliferation of breast cancers cells. This research aimed to find the bioactive compounds from Allium sativum for inhibiting HER2 enzyme by using molecular docking method. Materials and method: The protein tyrosin kinase HER2 structure was obtained from Protein Data Bank. Compounds were collected from previous publications of Allium sativum and these structures were retrieved from PubChem database. Molecular docking was done by Autodock vina software. Lipinski’s rule of 5 is used to compare compounds with drug-like and non-drug-like properties. Pharmacokinetic parameters of potential compounds were evaluated using the pkCSM tool. Results: Based on previous publication of Allium sativum, we have collected 55 compounds. The results showed that 2 compounds have HER2 inhibitory activity stronger than the reference compounds including biochanin A và cyanidin 3-malonylglucoside. The Lipinski’s rule of Five showed that these two compounds had propietary drug-likenesss. Moreover, predict ADMET of these compounds was also analyzed. Conclusion: Therefore, biochanin A and cyanidin 3-malonylglucoside may be potential natural product compounds for HER2-positive breast cancer treatment. Keywords: Allium sativum, tyrosin kinase HER2, breast cancer HER2 positive, in silico, molecular docking. References [1] S. Libson, M. Lippman. A review of clinical aspects of breast cancer. International review of psychiatry (Abingdon, England) 26(1) (2014) 4.[2] D.J. Slamon, G.M. Clark, S.G. Wong, W.J. Levin, A. Ullrich, W.L. McGuire. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235(4785) (1987) 177.[3] U. Krishnamurti, J.F. Silverman. 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Background: Traditional medicine used Mimosa pudica Linn. for diabetes treatment. This study evaluates the antidiabetic and renoprotective of ethyl acetate fraction of M.pudica leaves on streptozotocin-induced diabetes in mice. Methods: The cold maceration method was used to extract M.pudica leaves with 80% ethanol at room temperature. Ethyl acetate (EtOAc) fraction was obtained from the M.pudica leaves extract by successively partitioning with different solvents. Mice were induced diabetes type 2 by streptozotocin (STZ) at a low dose and treated with EtOAc fraction of M. pudica leaves at 50 mg/kg and 100 mg/kg b.w for 60 days. After 24 hours of the final dose of therapy, the mice were sacrificed to extract blood and kidney tissues for biochemical and histopathological analysis. Results: The EtOAc fraction of M. pudica leaves showed strong activity in improving glucose concentration in oral glucose tolerance test. Our results showed that EtOAc fraction significantly decreased levels of glucose, total cholesterol (TC), low-density lipoprotein (LDL), triglyceride (TG), and increased the level of high-density lipoprotein (HDL) and protected kidney against damages in mice. EtOAc fraction also increased the levels of antioxidant enzymes including catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), activities, and decreased malondialdehyde (MDA) formation, pro-inflammatory cytokines (IL-1β and TNF-α) in kidney tissues. Moreover, renoprotective effect was also observed in the histopathological analysis. Conclusion: Our findings support that EtOAc fraction of M. pudica leaves have potent anti-diabetic nephropathy activity by decreasing of pro-inflammatory cytokines and improving antioxidant levels.

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