Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration

Jiang, Nan; Wu, Chung Hsin; Xingqin, Zhou; Zhai, Guangju; Wu, Jian

doi:10.1155/2021/5353785

Cited by 19 publications

(13 citation statements)

References 76 publications

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“…Moreover, its safety is very high, and so far there are few reports of adverse effects ( Pai et al, 2021 ). There is increasing evidence that Li-ESWT causes minor damage to vital organs such as the heart while improving myocardium, bladder, joints, and penis function ( Jiang et al, 2021 ).…”

Section: Physical Therapy Of Edmentioning

confidence: 99%

Advances in physical diagnosis and treatment of male erectile dysfunction

Pang

Pan

et al. 2023

Front. Physiol.

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Erectile dysfunction (ED) is the most common male sexual dysfunction by far and the prevalence is increasing year after year. As technology advances, a wide range of physical diagnosis tools and therapeutic approaches have been developed for ED. At present, typical diagnostic devices include erection basic parameter measuring instrument, erection hardness quantitative analysis system, hemodynamic testing equipment, nocturnal erection measuring instrument, nerve conduction testing equipment, etc. At present, the most commonly used treatment for ED is pharmacological therapy represented by phosphodiesterase five inhibitors (PDE5i). As a first-line drug in clinical, PDE5i has outstanding clinical effects, but there are still some problems that deserve the attention of researchers, such as cost issues and some side effects, like visual disturbances, indigestion, myalgia, and back pain, as well as some non-response rates. Some patients have to consider alternative treatments. Moreover, the efficacy in some angiogenic EDs (diabetes and cardiovascular disease) has not met expectations, so there is still a need to continuously develop new methods that can improve hemodynamics. While drug have now been shown to be effective in treating ED, they only control symptoms and do not restore function in most cases. The increasing prevalence of ED also makes us more motivated to find safer, more effective, and simpler treatments. The exploration of relevant mechanisms can also serve as a springboard for the development of more clinically meaningful physiotherapy approaches. Therefore, people are currently devoted to studying the effects of physical therapy and physical therapy combined with drug therapy on ED. We reviewed the diagnosis of ED and related physical therapy methods, and explored the pathogenesis of ED. In our opinion, these treatment methods could help many ED patients recover fully or partially from ED within the next few decades.

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Section: Physical Therapy Of Edmentioning

confidence: 99%

Advances in physical diagnosis and treatment of male erectile dysfunction

Pang

Pan

et al. 2023

Front. Physiol.

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“…Prostate cancer surgery and other pelvic surgeries often result in damages to the cavernous nerve, which originates from the major pelvic ganglion (MPG) and controls the relaxation and contraction of CCSMCs, thus regulating the erection of the penis ( 71 ). It was reported that up to 80% of prostate cancer patients suffer from ED after radical prostatectomy ( 72 ).…”

Section: The Therapeutic Potential Of Exosomes In Edmentioning

confidence: 99%

Erectile dysfunction and exosome therapy

Feng

Wei²,

Deng³

et al. 2023

Front. Endocrinol.

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Erectile dysfunction (ED), as a common male disease, can seriously reduce the life quality of men and their partners. With the improvement of human living standards, ED is considered to be an important health issue that plagues men. However, it is difficult for existing therapeutic approaches to meet the needs of all patients, so it is necessary to develop novel treatment strategies. Exosomes, as a class of vesicles secreted by cells with bilayer membrane structure, are involved in various physiological and pathological processes in human body and considered to have great therapeutic potentials. This review summarizes the recent advances on exosome therapy with animal models of ED, and proposes the prospect of future research in order to provide a basis for clinical trials and clinical translation.

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“…Thus, currently, especially when tumor loco-regional extension allows for the use of a nerve-sparing RP technique, postoperative functional recovery has become the most important surgical goal. Due to the predisposing inherent regional pelvic anatomy, even in the hands of the most experienced surgeon, regardless of surgical technique or approach used, a certain degree of CN damage usually occurs during RP [ 10 ]. Additional strategies are required to improve EF outcomes after RP, seeing as contemporary treatment modalities, i.e., penile rehabilitation protocols, only provide a quicker recovery of EF, not a better rate of recovery overall [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Rats, Neuregulins and Radical Prostatectomy: A Conceptual Overview

Novacescu

Neşiu

Bardan

et al. 2023

JCM

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In the contemporary era of early detection, with mostly curative initial treatment for prostate cancer (PC), mortality rates have significantly diminished. In addition, mean age at initial PC diagnosis has decreased. Despite technical advancements, the probability of erectile function (EF) recovery post radical prostatectomy (RP) has not significantly changed throughout the last decade. Due to virtually unavoidable intraoperative cavernous nerve (CN) lesions and operations with younger patients, post-RP erectile dysfunction (ED) has now begun affecting these younger patients. To address this pervasive limitation, a plethora of CN lesion animal model investigations have analyzed the use of systemic/local treatments for EF recovery post-RP. Most promisingly, neuregulins (NRGs) have demonstrated neurotrophic effects in both neurodegenerative disease and peripheral nerve injury models. Recently, glial growth factor 2 (GGF2) has demonstrated far superior, dose-dependent, neuroprotective/restorative effects in the CN injury rat model, as compared to previous therapeutic counterparts. Although potentially impactful, these initial findings remain limited and under-investigated. In an effort to aid clinicians, our paper reviews post-RP ED pathogenesis and currently available therapeutic tools. To stimulate further experimentation, a standardized preparation protocol and in-depth analysis of applications for the CN injury rat model is provided. Lastly, we report on NRGs, such as GGF2, and their potentially revolutionary clinical applications, in hopes of identifying relevant future research directions.

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Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration

Cited by 19 publications

References 76 publications

Advances in physical diagnosis and treatment of male erectile dysfunction

Advances in physical diagnosis and treatment of male erectile dysfunction

Erectile dysfunction and exosome therapy

Rats, Neuregulins and Radical Prostatectomy: A Conceptual Overview

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