CAX3 (cation/proton exchanger) mediates a Cd tolerance by decreasing ROS through Ca elevation in Arabidopsis

Modareszadeh, Mahsa; Bahmani, Ramin; Kim, Dong-Gwan; Hwang, Seongbin

doi:10.1007/s11103-020-01072-1

Cited by 36 publications

(10 citation statements)

References 76 publications

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“…Four CAXs genes were downregulated in Xcc -infected samples of the R line compared with the Xcc -infected samples of the S line, which might block the efflux of Ca 2+ ions from the cytosol ( Figure 9 , Supplementary Table 6 ). Research has indicated that the deletion of CAX genes results in ROS and SA accumulation, thereby increasing disease resistance ( Modareszadeh et al., 2020 ; Zhang et al., 2020 ). Elevation of cytosolic Ca 2+ ions is known to repress H + -ATPase activity, cause apoplastic alkalinization, activate K + out channels, and lead to stomatal closure ( Bolwell et al., 2002 ).…”

Section: Discussionmentioning

confidence: 99%

Integrated metabolome and transcriptome analysis reveals salicylic acid and flavonoid pathways’ key roles in cabbage’s defense responses to Xanthomonas campestris pv. campestris

Sun

Zhang²,

Huang³

et al. 2022

Front. Plant Sci.

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Xanthomonas campestris pv. campestris (Xcc) is a vascular bacteria pathogen causing black rot in cabbage. Here, the resistance mechanisms of cabbage against Xcc infection were explored by integrated metabolome and transcriptome analysis. Pathogen perception, hormone metabolisms, sugar metabolisms, and phenylpropanoid metabolisms in cabbage were systemically re-programmed at both transcriptional and metabolic levels after Xcc infection. Notably, the salicylic acid (SA) metabolism pathway was highly enriched in resistant lines following Xcc infection, indicating that the SA metabolism pathway may positively regulate the resistance of Xcc. Moreover, we also validated our hypothesis by showing that the flavonoid pathway metabolites chlorogenic acid and caffeic acid could effectively inhibit the growth of Xcc. These findings provide valuable insights and resource datasets for further exploring Xcc–cabbage interactions and help uncover molecular breeding targets for black rot-resistant varieties in cabbage.

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Section: Discussionmentioning

confidence: 99%

Integrated metabolome and transcriptome analysis reveals salicylic acid and flavonoid pathways’ key roles in cabbage’s defense responses to Xanthomonas campestris pv. campestris

Sun

Zhang²,

Huang³

et al. 2022

Front. Plant Sci.

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“…Under Mg deficiency, the relationship between the increased MYB30 transcripts and ROS‐associated SAA deserves further investigation. Consistently, CAX3, whose transcript level was altered in the myb30 mutant (Yan et al, 2020), could enhance cadmium (Cd) tolerance by reducing ROS generation through improved anti‐oxidative enzyme activities (Modareszadeh et al, 2021). CAX3 is one of several CAX family members that respond to Mg deficiency.…”

Section: Discussionmentioning

confidence: 99%

Combined analyses of translatome and transcriptome in Arabidopsis reveal new players responding to magnesium deficiency

Beuchat

et al. 2021

JIPB

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Translational control of gene expression, including recruitment of ribosomes to messenger RNA (mRNA), is particularly important during the response to stress. Purification of ribosome‐associated mRNAs using translating ribosome affinity purification (TRAP) followed by RNA‐sequencing facilitates the study of mRNAs undergoing active transcription and better proxies the translatome, or protein response, to stimuli. To identify plant responses to Magnesium (Mg) deficiency at the translational level, we combined transcriptome and translatome analyses. Excitingly, we found 26 previously unreported Mg‐responsive genes that were only regulated at the translational level and not the transcriptional level, during the early response to Mg deficiency. In addition, mutants of the transcription factor ELONGATED HYPOCOTYL 5 (HY5), the H+/CATION EXCHANGER 1 and 3 (CAX1 and CAX3), and UBIQUITIN 11 (UBQ11) exhibited early chlorosis phenotype under Mg deficiency, supporting their functional involvement in ion homeostasis. Overall, our study strongly supports that TRAP‐seq combined with RNA‐seq followed by phenotype screening could facilitate the identification of novel players during stress responses.

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“…Heavy metal, cadmium-induced [Ca 2+ ] cyt was predominantly mediated by CAXs. AtCAX1, AtCAX3, and AtCAX4 contribute to Cd transport in a Cd stress condition and led to Cd tolerance ( Wu et al, 2011 , 2020 ; Baliardini et al, 2015 ; Ahmadi et al, 2018 ; Modareszadeh et al, 2021 ). However, these results still need to be confirmed to better understand whether they resulted from direct transport of metals by CAXs ions or by an alteration of a stress tolerance pathway by CAXs via maintaining [Ca 2+ ] cyt homeostasis.…”

Section: Ca 2+ Effluxmentioning

confidence: 99%

Calcium channels and transporters: Roles in response to biotic and abiotic stresses

Park

Shin²

2022

Front. Plant Sci.

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Calcium (Ca2+) serves as a ubiquitous second messenger by mediating various signaling pathways and responding to numerous environmental conditions in eukaryotes. Therefore, plant cells have developed complex mechanisms of Ca2+ communication across the membrane, receiving the message from their surroundings and transducing the information into cells and organelles. A wide range of biotic and abiotic stresses cause the increase in [Ca2+]cyt as a result of the Ca2+ influx permitted by membrane-localized Ca2+ permeable cation channels such as CYCLIC NUCLEOTIDE-GATE CHANNELs (CNGCs), and voltage-dependent HYPERPOLARIZATION-ACTIVATED CALCIUM2+ PERMEABLE CHANNELs (HACCs), as well as GLUTAMATE RECEPTOR-LIKE RECEPTORs (GLRs) and TWO-PORE CHANNELs (TPCs). Recently, resistosomes formed by some NUCLEOTIDE-BINDING LEUCINE-RICH REPEAT RECEPTORs (NLRs) are also proposed as a new type of Ca2+ permeable cation channels. On the contrary, some Ca2+ transporting membrane proteins, mainly Ca2+-ATPase and Ca2+/H+ exchangers, are involved in Ca2+ efflux for removal of the excessive [Ca2+]cyt in order to maintain the Ca2+ homeostasis in cells. The Ca2+ efflux mechanisms mediate the wide ranges of cellular activities responding to external and internal stimuli. In this review, we will summarize and discuss the recent discoveries of various membrane proteins involved in Ca2+ influx and efflux which play an essential role in fine-tuning the processing of information for plant responses to abiotic and biotic stresses.

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CAX3 (cation/proton exchanger) mediates a Cd tolerance by decreasing ROS through Ca elevation in Arabidopsis

Cited by 36 publications

References 76 publications

Integrated metabolome and transcriptome analysis reveals salicylic acid and flavonoid pathways’ key roles in cabbage’s defense responses to Xanthomonas campestris pv. campestris

Integrated metabolome and transcriptome analysis reveals salicylic acid and flavonoid pathways’ key roles in cabbage’s defense responses to Xanthomonas campestris pv. campestris

Combined analyses of translatome and transcriptome in Arabidopsis reveal new players responding to magnesium deficiency

Calcium channels and transporters: Roles in response to biotic and abiotic stresses

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