Cayratia japonica Prevents Ulcerative Colitis by Promoting M2 Macrophage Polarization through Blocking the TLR4/MAPK/NF-κB Pathway

Sun, Jun; Zhao, Ping; Ding, Xufeng; Li, Fang; Jiang, Jie; Huang, Hongjuan; Ji, Lijiang

doi:10.1155/2022/1108569

Cited by 7 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mφs are antigen-presenting cells that connect the innate and adaptive immune systems and have high plasticity [ 45 ]. The M1 phenotype of macrophages can up-regulate inflammatory factors and chemokines, promote the production of reactive oxygen species and reactive nitrogen, while the M2 phenotype can inhibit inflammatory reactions and promote wound healing [ 46 ]. Inhibiting the polarization of M1 macrophages contributes to reducing DSS-induced colitis damage [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Hordenine on a Model of Ulcerative Colitis

Zhang

Ding

et al. 2023

Molecules

View full text Add to dashboard Cite

Hordenine, a phenethylamine alkaloid, is found in a variety of plants and exhibits a broad array of biological activities and pharmacological properties, including anti-inflammatory and anti-fibrotic effects. However, the efficacy and underlying mechanisms of hordenine in treating ulcerative colitis (UC) remain unclear. To address this, we examined the therapeutic effects of hordenine on dextran sodium sulphate (DSS)-induced UC by comparing disease activity index (DAI), colon length, secretion of inflammatory factors, and degree of colonic histological lesions across diseased mice that were and were not treated with hordenine. We found that hordenine significantly reduced DAI and levels of pro-inflammatory factors, including interleukin (IL)-6, IL-1β, and tumor necrosis factor alpha (TNF-α), and also alleviated colon tissue oedema, colonic lesions, inflammatory cells infiltration and decreased the number of goblet cells. Moreover, in vitro experiments showed that hordenine protected intestinal epithelial barrier function by increasing the expression of tight junction proteins including ZO-1 and occludin, while also promoting the healing of intestinal mucosa. Using immunohistochemistry and western blotting, we demonstrated that hordenine reduced the expression of sphingosine kinase 1 (SPHK1), sphingosine-1-phosphate receptor 1 (S1PR1), and ras-related C3 botulinum toxin substrate 1 (Rac1), and it inhibited the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in colon tissues. Thus, hordenine appears to be effective in UC treatment owing to pharmacological mechanisms that favor mucosal healing and the inhibition of SPHK-1/S1PR1/STAT3 signaling.

show abstract

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Hordenine on a Model of Ulcerative Colitis

Zhang

Ding

et al. 2023

Molecules

View full text Add to dashboard Cite

show abstract

“…One study revealed that CJ can inhibit the TLR4/MAPK/NF-κB signaling pathway and macrophage M1 polarization. This promotes M2-like polarization, thereby reducing DSS-induced immunoinflammation in UC models and lessening colon damage ( 47 ). Berberine (BBR) is a common treatment for gastrointestinal disorders.…”

Section: Potential Treatment Of Tcm For Iciicmentioning

confidence: 99%

Potential application mechanism of traditional Chinese medicine in treating immune checkpoint inhibitor-induced colitis

Wang,

Guo,

Shen

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Cancer ranks among the foremost causes of mortality worldwide, posing a significant threat to human lives. The advent of tumor immunotherapy has substantially transformed the therapeutic landscape for numerous advanced malignancies, notably non-small cell lung cancer and melanoma. However, as immune checkpoint inhibitors (ICIs) are increasingly applied in clinical settings, a spectrum of undesired reactions, termed immune-related adverse events (irAEs), has emerged. These adverse reactions are associated with immunotherapy and can result in varying degrees of harm to the human body. Among these reactions, Immune checkpoint inhibitor-induced colitis (ICIIC) stands out as one of the most prevalent clinical adverse events. In contemporary times, traditional Chinese medicine (TCM) has demonstrated remarkable efficacy in addressing various maladies. Consequently, investigating the potential application and mechanisms of Chinese medicine in countering immune checkpoint inhibitor-induced colitis assumes significant importance in the treatment of this condition.

show abstract