2006
DOI: 10.1038/nm1421
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CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis

Abstract: Hepatic fibrosis, the common response associated with chronic liver diseases, ultimately leads to cirrhosis, a major public health problem worldwide. We recently showed that activation of hepatic cannabinoid CB2 receptors limits progression of experimental liver fibrosis. We also found that during the course of chronic hepatitis C, daily cannabis use is an independent predictor of fibrosis progression. Overall, these results suggest that endocannabinoids may drive both CB2-mediated antifibrogenic effects and C… Show more

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Cited by 485 publications
(482 citation statements)
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“…Studies in human livers and mouse models of fibrosis demonstrate upregulated expression of the cannabinoid receptors, CB1 and CB2, in chronic liver injury compared to normal controls (8,9). Immunohistochemical staining of human specimen with cirrhosis shows localization of the CB receptors to hepatic myofibroblasts (8,9).…”
Section: Discussionmentioning
confidence: 99%
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“…Studies in human livers and mouse models of fibrosis demonstrate upregulated expression of the cannabinoid receptors, CB1 and CB2, in chronic liver injury compared to normal controls (8,9). Immunohistochemical staining of human specimen with cirrhosis shows localization of the CB receptors to hepatic myofibroblasts (8,9).…”
Section: Discussionmentioning
confidence: 99%
“…Studies in human livers and mouse models of fibrosis demonstrate upregulated expression of the cannabinoid receptors, CB1 and CB2, in chronic liver injury compared to normal controls (8,9). Immunohistochemical staining of human specimen with cirrhosis shows localization of the CB receptors to hepatic myofibroblasts (8,9). In experimental models of fibrosis, CB1 receptor activation is associated with profibrogenic effects whereas CB2 receptor activation is associated with antifibrogenic effects (8,9).…”
Section: Discussionmentioning
confidence: 99%
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