2013
DOI: 10.1530/joe-13-0192
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CB1 receptor mediates the effects of glucocorticoids on AMPK activity in the hypothalamus

Abstract: AMP-activated protein kinase (AMPK), a regulator of cellular and systemic energy homeostasis, can be influenced by several hormones. Tissue-specific alteration of AMPK activity by glucocorticoids may explain the increase in appetite, the accumulation of lipids in adipose tissues, and the detrimental cardiac effects of Cushing's syndrome. Endocannabinoids are known to mediate the effects of various hormones and to influence AMPK activity. Cannabinoids have central orexigenic and direct peripheral metabolic effe… Show more

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Cited by 28 publications
(21 citation statements)
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“…Scerif et al (55) showed significant differences in GC-treated WT and cannabinoid receptor type 1 KO mice, and more recently, similar data showed the role of the cannabinoid system in GC-induced changes (82).…”
Section: European Journal Of Endocrinologymentioning
confidence: 80%
See 2 more Smart Citations
“…Scerif et al (55) showed significant differences in GC-treated WT and cannabinoid receptor type 1 KO mice, and more recently, similar data showed the role of the cannabinoid system in GC-induced changes (82).…”
Section: European Journal Of Endocrinologymentioning
confidence: 80%
“…Moreover, GCs have been shown to upregulate the gene expression of orexigenic peptides (NPY and agouti-related peptide) in rat arcuate nucleus also via AMPK (60). The GC effect on hypothalamic AMPK is lacking in cannabinoid receptor 1-knockout (KO) animals, supporting the hypothesis that cannabinoids are involved in the hypothalamic AMPK and possibly the appetite effects of GCs (55).…”
Section: Gcs and Obesitymentioning
confidence: 94%
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“…Interestingly, when treated with 10 µg/mL of hemp extracts, the level of iNOS and IL-1β gene expressions along with PGE2 production were nearly equivalent to that of dexamathasone-treated cells, regardless of the specific hemp cultivar. This phenomenon might involve activation of CB receptor, which has been found to mediate the function of GR [29].…”
Section: Discussionmentioning
confidence: 99%
“…It is estimated that 1.2% of the US population is currently being treated with a prescription GC drug (21). Chronic use of GCs, however, disturbs normal homeostasis and causes deleterious side-effects in humans and rodents including dysregulation of glucose and fat metabolism, hepatosteatosis, insulin resistance, diabetes, osteoporosis, muscle wasting, growth retardation, infertility, cognitive dysfunction, glaucoma, cataracts and topical skin thinning (1,3,5,(22)(23)(24)(25)(26). Given the importance of GC drugs in the treatment of chronic inflammatory diseases, the ideal therapeutic would be one that retained the antiinflammatory actions of GCs without inducing the negative side effects.…”
mentioning
confidence: 99%