Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature

Singh, Tejbir; Vieyra-Garcia, Pablo A.; Wagner, Karin; Penninger, Josef; Wolf, Peter

doi:10.1038/s41419-018-0858-5

Cited by 17 publications

(15 citation statements)

References 51 publications

(60 reference statements)

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“…[46] One latest research also verified that mitochondrial dysfunction led to skin wrinkles in young mice. [47] DRP1 is a core component for mitochondrial fission, [28] while OPA1 is as a fusion-associated protein. [27] These two proteins have been proposed as novel therapeutic targets for maintaining a physiological redox.…”

Section: H 2 S Inhibited Methylglyoxal-induced Cell Viability and Rosmentioning

confidence: 99%

Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

Hua

et al. 2019

Experimental Dermatology

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Hydrogen sulphide (H2S) is an important gasotransmitter with several physiological functions. However, the roles and the detailed mechanisms of H2S on skin wound healing are not known well. In the present study, 129S1/SvImJ mice were intraperitoneally injected with NaHS (50 μmol/kg/d) for 2 weeks. Then, a round wound of 6 mm diameter with depth into the dermis was made. The skin wound area, blood perfusion, superoxide production, malondialdehyde (MDA) levels, total antioxidant capacity (T‐AOC), expression of vascular endothelial growth factor (VEGF), dynamin‐related protein 1 (DRP1) and optic atrophy 1 (OPA1) were measured. After NaHS (50 μmol/L) pre‐administration for 4 hours, cell migration rate, DRP1, OPA1 and α–smooth muscle actin (α‐SMA) expression, superoxide production and mitochondrial membrane potential in primary skin fibroblasts were measured. Tube formation in human umbilical vein endothelial cells (HUVECs) and cell migration in human keratinocytes were also measured. The results showed that NaHS pretreatment significantly accelerated wound healing and improved blood flow in the wound after operation. NaHS increased VEGF expression in the wound and promoted tube formation in HUVECs. Meanwhile, NaHS attenuated reactive oxygen species (ROS) production, suppressed MDA level but restored T‐AOC in the wound. NaHS also promoted skin fibroblasts migration and α‐SMA expression after scratch. Moreover, NaHS alleviated ROS, increased mitochondrial membrane potential, decreased DRP1 but enhanced OPA1 expression in skin fibroblasts after scratch. NaHS also accelerated human keratinocytes migration after scratch. Taken together, exogenous H2S supplementary accelerated the skin wound healing, which might be related to oxidative stress inhibition and VEGF enhancement.

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Section: H 2 S Inhibited Methylglyoxal-induced Cell Viability and Rosmentioning

confidence: 99%

Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

Hua

et al. 2019

Experimental Dermatology

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“…Moreover, miR-203, targeting ABL1, SOCS3, and ZEB3, controls EMT in epithelial cancers 28,31 . miRNAs also play a key role in epithelial cells upon different environmental stressors, such us UV radiations and inflammation [32][33][34][35][36] .…”

Section: Epithelial Ncrnasmentioning

confidence: 99%

The role of noncoding RNAs in epithelial cancer

et al. 2020

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Regulatory noncoding RNAs (ncRNAs) are a class of RNAs transcribed by regions of the human genome that do not encode for proteins. The three main members of this class, named microRNA, long noncoding RNA, and circular RNA play a key role in the regulation of gene expression, eventually shaping critical cellular processes. Compelling experimental evidence shows that ncRNAs function either as tumor suppressors or oncogenes by participating in the regulation of one or several cancer hallmarks, including evading cell death, and their expression is frequently deregulated during cancer onset, progression, and dissemination. More recently, preclinical and clinical studies indicate that ncRNAs are potential biomarkers for monitoring cancer progression, relapse, and response to cancer therapy. Here, we will discuss the role of noncoding RNAs in regulating cancer cell death, focusing on those ncRNAs with a potential clinical relevance. Facts • Many of the genetic and epigenetics alterations in human cancers are found in noncoding regions of the DNA. How can we integrate preclinical findings to select the best regulatory ncRNA for clinical studies?

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“…Links from the data set-based networks are normalized by degree and multiplied to produce a weighted composite network. GeneMANIA also supports a user-friendly Cytoscape add-on [ 119 ] and furthermore focuses on single gene and gene set function prediction [ 120 – 122 ].…”

Section: Network Resourcesmentioning

confidence: 99%

Genome-wide functional association networks: background, data & state-of-the-art resources

Guala

Ogris

Müller

et al. 2019

Briefings in Bioinformatics

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The vast amount of experimental data from recent advances in the field of high-throughput biology begs for integration into more complex data structures such as genome-wide functional association networks. Such networks have been used for elucidation of the interplay of intra-cellular molecules to make advances ranging from the basic science understanding of evolutionary processes to the more translational field of precision medicine. The allure of the field has resulted in rapid growth of the number of available network resources, each with unique attributes exploitable to answer different biological questions. Unfortunately, the high volume of network resources makes it impossible for the intended user to select an appropriate tool for their particular research question. The aim of this paper is to provide an overview of the underlying data and representative network resources as well as to mention methods of integration, allowing a customized approach to resource selection. Additionally, this report will provide a primer for researchers venturing into the field of network integration.

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Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature

Cited by 17 publications

References 51 publications

Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

The role of noncoding RNAs in epithelial cancer

Genome-wide functional association networks: background, data & state-of-the-art resources

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