CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2010–2014

Abstract

This report presents the following population-based measures: incidence rates, mortality rates, and relative survival rates (for more information on definitions of terms and Estimation of Expected Numbers of Brain and Other CNS Tumors in 2017 and 2018Estimated numbers of expected malignant and non-malignant brain and other CNS tumors were calculated for 2017 and 2018. To project estimates of newly diagnosed brain and other CNS tumors in 2017 and 2018, age-adjusted annual brain tumor incidence rates were generated for 2000-2014 for malignant tumors, and 2006-2014 for nonmalignant tumors. These were generated by state, age, and histologic type. Joinpoint 4.2.0.2 32 was used to fit regression models to these incidence rates, 33 which were used to predict numbers of cases in future years using the parameter from the selected models. Joinpoint regression allows for multiple lines to be fit to incidence data across time, rather than assuming a consistent trend across the whole period. The points where these lines intersect are called 'joinpoints'. The models allowed for a maximum of 2 joinpoints (1 for non-malignant tumors), a minimum of 3 observations from a joinpoint to either end of the data, and a minimum of 3 observations between joinpoints. 34 Modified Bayesian Information Criterion procedures included in Joinpoint were used to select the best fitting model. Overall total rates presented are based on total malignant and

Maternal Folate Intake and Risk of Childhood Brain and Spinal Cord Tumors: A Systematic Review and Meta-Analysis

“…CNS and miscellaneous intracranial and intraspinal neoplasms are the most common form of solid tumors in children (0-14 years) and represent the leading cause of cancer mortality in this age-group [5]. In the United States, the overall annual average age-adjusted incidence rate for 2010-2014 for CBSCT was 4.89 (95% IC 4.83-4.96) per 100,000 population for children and adolescents (0-19 years) and 4.75 (95% IC 4.67-4.83) per 100,000 population for children [5].…”

“…In the United States, the overall annual average age-adjusted incidence rate for 2010-2014 for CBSCT was 4.89 (95% IC 4.83-4.96) per 100,000 population for children and adolescents (0-19 years) and 4.75 (95% IC 4.67-4.83) per 100,000 population for children [5]. The 5-year relative survival rate for the CBSCT in the United States during 2007 through 2013 was 72.5% for children (0-14 years) and 78.9% for adolescents (15-19 years) [6].…”

Conventional and advanced magnetic resonance imaging in patients with high-grade glioma

“…Glial tumors constitute approximately three-fourths of primary malignant brain neoplasms and are largely responsible for poor outcomes of brain tumor patients. 1 …”

Survival rates in patients with the newly diagnosed glioblastoma: Data from the National Cancer Registry of Ukraine, 2008-2016

“…The incompletion of GBM cases collected in the NCR could explain the low incidence of GBMs (0.58-1.30 per 100,000) in contrast to data of other countries: 3.20 per 100,000/year for the US, 4.64 per 100,000/year for the UK [3,4].…”

“…With the annual incidence of 3.2-6.1 per 100,000/year, GBM presents approximately the half of newly diagnosed primary brain neoplasms. As all anaplastic gliomas, GBM is characterized by infiltrative growth and rapid proliferation that determines high rates of recurrence and progressing neurological deterioration [1][2][3][4].…”