CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions

Jung, Johannes; Buisman, Sonja; Weersing, Ellen; Dethmers-Ausema, Albertina; Zwart, Erik; Schepers, Hein; Dekker, Mike R.; Lazare, Seka; Hammerl, Franziska; Skokova, Yulia; Kooistra, Susanne M.; Klauke, Karin; Poot, Raymond A.; Bystrykh, Leonid; Haan, Gerald de

doi:10.1016/j.celrep.2019.01.050

Cited by 28 publications

(22 citation statements)

References 36 publications

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“…Furthermore, CBX7 (part of the polycomb repressive complex) was one of the top genes expressed by cluster 6 macrophages. CBX7 regulates HSC self-renewal and its downregulation induces macrophage differentiation (Jung et al, 2019;Klauke et al, 2013). Overall, these findings suggest that cluster 6 represents a transitional macrophage stage before terminal differentiation into mature lung macrophages.…”

Section: Extravascular Hla-dr Hi Monocytes Represent a Cellular Intermediate In Human Lung Macrophage Developmentmentioning

confidence: 66%

Distinct developmental pathways from blood monocytes generate human lung macrophage diversity

et al. 2021

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Section: Extravascular Hla-dr Hi Monocytes Represent a Cellular Intermediate In Human Lung Macrophage Developmentmentioning

confidence: 66%

Distinct developmental pathways from blood monocytes generate human lung macrophage diversity

et al. 2021

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“…Downregulation of CBX7 is associated with HCC progression and poor prognosis in patients with HCC 21 . Moreover, CBX7 was found to induce self-renewal of malignant hematopoietic stem and progenitor cells 22 . However, several studies have shown that CBX7 could be an oncogene in multiple types of human cancers.…”

Section: Discussionmentioning

confidence: 99%

CBX7 Inhibits Cell Growth and Motility and Induces Apoptosis in Cervical Cancer Cells

Yan

Tian

et al. 2019

Molecular Therapy - Oncolytics

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The chromobox protein homolog 7 (CBX7), one member of the polycomb group family, has been characterized mainly to play a tumor-suppressive role in human malignant neoplasias. Moreover, downregulation of CBX7 is correlated with poor prognosis and aggressiveness in a variety of human cancers. However, the biological functions and role of CBX7 in cervical cancer have not been elucidated. In the present study, we explore whether CBX7 exerts its tumor-suppressive function in cervical cancer. To achieve this goal, molecular approaches were used to upregulate the expression of CBX7 or downregulation of CBX7 in cervical cancer cell lines. We observed that overexpression of CBX7 inhibited cell growth and induced apoptosis in cervical cancer cells. CBX7 overexpression retarded cell migration and invasion in cervical cancer cells. In line with this, downregulation of CBX7 promoted cell growth and migration as well as invasion in cervical cancer cells. Our findings suggest that CBX7 might be a tumor suppressor and could be a potential target in cervical cancer.

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“…Federico et al found that CBX7 and Protein Arginine Methyltransferase 1 (PRMT1) complex is critical for PRMT1 and for the expression of E-cadherin, a crucial hallmark of EMT [28]. Jung et al demonstrated that CBX7 act as a crucial regulator that induces human malignant hematopoietic stem and progenitor cells by noncanonical and canonical interactions and higher expression of CBX7 can also inhibit proliferation and promoted differentiation in acute myeloid leukemia, revealing therapeutic possibilities for leukemia [29]. Consistently, the present study revealed that CBX7 expression was related to OS in CESC, and the potential mechanism may be correlated with the biosynthesis of unsaturated fatty acids and O-glycan, protein export, glyoxylate and dicarboxylate metabolism, glycosaminoglycan biosynthesis-chondroitin sulfate, one carbon pool by folate and the nod-like receptor signaling pathway, as identi ed by GSEA.…”

Section: Discussionmentioning

confidence: 99%

Decreased Expression of CBX7 is an Independent Predictor of Poor Survival in Cervical Cancer

An¹,

Zhang²,

Jin³

et al. 2021

Preprint

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Background: CBX7, a component of the PRC1, has been investigated as a potential biomarker in human malignant neoplasias. In present study, the value of CBX7 expression in the diagnostic and prognosis of cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) as examined via bioinformatics analysis of data obtained from Genotype-Tissue Expression (GTEx) database and The Cancer Genome Atlas (TCGA) database.Methods: Relationships between clinical factors and CBX7 were explored. The Kaplan-Meier method and Cox regression were used to identify the associations between clinicopathological characteristics and overall survival (OS) in CESC. Gene set enrichment analysis (GSEA) was performed using TCGA dataset. Results: Our results indicated the decreased expression of CBX7 in CESC, and difference in CBX7 expression was also identified according to age subgroups. CESC patients with decreased CBX7 expression had worse prognosis than those with high CBX7 expression. Multivariate analysis showed that CBX7 was an independent risk factor for OS. GSEA demonstrated pathways involved in the biosynthesis of unsaturated fatty acids, glycosaminoglycan biosynthesis-chondroitin sulfate, glyoxylate and dicarboxylate metabolism, nod-like receptor signaling pathway, O-glycan biosynthesis, one carbon pool by folate and protein export as differentially enriched in CESC with decreased CBX7 expression.Conclusion: We demonstrated that decreased CBX7 expression may be a potential independent biomarker for poor prognosis in CESC.

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CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions

Abstract: Highlights d CBX7 regulates self-renewal of human primitive normal and leukemic cells d CBX7 binds SETDB1 and its inhibition induces differentiation of AML

Cited by 28 publications

References 36 publications

Distinct developmental pathways from blood monocytes generate human lung macrophage diversity

Distinct developmental pathways from blood monocytes generate human lung macrophage diversity

CBX7 Inhibits Cell Growth and Motility and Induces Apoptosis in Cervical Cancer Cells

Decreased Expression of CBX7 is an Independent Predictor of Poor Survival in Cervical Cancer

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