CC chemokine receptor 5 (CCR5) deletion polymorphism does not protect Czech males against early myocardial infarction

Chemokine receptor 5 (CCR5) deletion polymorphism in North Indian patients with coronary artery disease

“…In the case of heart disease studies, Spain CAD patients showed significant difference in association of Δ32 allele frequency compared to other European samples (Table 3). Germans, Czech Republic, Hungary and Greece studies failed to replicate protective effect observed in Spanish population [10,13,15]. Similarly, in our North Indian population, there seems to be no protective effect of CCR5 delta polymorphism on CAD rather a susceptible effect is probable with high odds ratio (3.08).…”

Polymorphisms in CCL2&CCL5 chemokines/chemokine receptors genes and their association with diseases

“…However, there was no difference in CCR5Δ32 allele distribution between patients and controls. This relationship between CAD and CCR5Δ32 was not observed in a German study 16 as well as in Czech males, who had their first MI before the age of 55 years 108 . In addition, CCR5Δ32 can increase the degree of calcification in specific conditions 109 .…”

Role of polymorphisms of CC-chemokine receptor-5 gene in acute myocardial infarction and biological implications for longevity

“…However, conflicting results have been obtained regarding the CCR5 role in atherosclerosis. [3][4][5] In this study, we evaluated whether CCR5∆32 variant and two other functional single nucleotide polymorphisms (SNPs) in CCR5 gene promoter 6,7 might be associated with AMI. We also analyzed their distribution in centenarians, since our previous studies have demonstrated that alleles associated with AMI susceptibility are not included in the genetic background favoring longevity.…”