CC9 Livestock-Associated Staphylococcus aureus Emerges in Bloodstream Infections in French Patients Unconnected With Animal Farming

Abstract

We report 4 bloodstream infections associated with CC9 agr type II Staphylococcus aureus in individuals without animal exposure. We demonstrate, by microarray analysis, the presence of egc cluster, fnbA, cap operon, lukS, set2, set12, splE, splD, sak, epiD, and can, genomic features associated with a high virulence potential in humans.

Molecular characterization of Staphylococcus aureus isolated from humans related to a livestock farm in Spain, with detection of MRSA-CC130 carrying mecC gene: A zoonotic case?

“…34 Similarly CC9 has been detected in meat samples in Spain 35 and in bloodstream infections in France, 36 with similar patterns of resistance, particularly resistance to erythromycin, but the difference is of methicillin resistance in our case. This MSSA profile and the presence of IEC type-B, points to the possible human origin of this clone and reveals its great capacity for colonization in different environments.…”

Global distribution and diversity of ovine-associated Staphylococcus aureus

“…This broad host range suggests this is a potentially zoonotic lineage. A recent report of CC9 bloodstream infections in humans not associated with livestock (Lamamy et al, 2013), might indicate that isolates within CC9 are becoming host-adapted and spreading within a host population. Similarly, strains from CC5 are being isolated from an increasing diversity of host species.…”

Livestock‐associated meticillin‐resistant Staphylococcus aureus in a young harbour seal (Phoca vitulina) with endocarditis

“…Therefore, this strain could be classified as LA-MRSA. 2 It did not contain the Panton-Valentine leucocidin virulence gene, which is associated with increased virulence of certain strains of S aureus. 15…”

“…1 The meticillin-resistant variant (meticillin-resistant S. aureus, MRSA) is regarded as a serious healthcare threat in hospitals as well as in the community as it is an extremely versatile pathogen also colonising and infecting animals. [2][3][4][5] Worldwide, MRSA belonging to clonal complex (CC) 398 and CC9 are associated with livestock, food products and people in contact with livestock. These isolates are referred to as livestock-associated (LA) MRSA.…”

“…These isolates are referred to as livestock-associated (LA) MRSA. 2 Other types are considered to be primarily human associated. MRSA from wildlife is rare and the result of overflow from livestock or humans.…”