CCAR2 negatively regulates IL-8 production in cervical cancer cells

Kim, Wootae; Pyo, Jaehyuk; Noh, Byeong‐Joo; Jeong, Joo‐Won; Lee, Juhie; Kim, Ja Eun

doi:10.18632/oncotarget.23199

Cited by 5 publications

(4 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We show herein that CCAR2 co-immunoprecipitates with ESRP1 in HCA24 cells, but its expression was not regulated by ESRP1 level in the different CRC cell lines used in the present study. CCAR2, found on human chromosome 8 (8p21.3), is involved in multiple cellular processes, and like ESRP1, it has a dual role in cancer depending on the context [33]. Importantly, CCAR2 is a core component of the DBIRD complex, a multiprotein complex, which acts at the interface between core messenger RNP particles and RNA polymerase II, and integrates transcript elongation with regulation of alternative splicing [34].…”

Section: Discussionmentioning

confidence: 99%

Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells

Ala

Manco

Mandili

et al. 2020

IJMS

View full text Add to dashboard Cite

The RNA-binding protein, Epithelial Splicing Regulatory Protein 1 (ESRP1) can promote or suppress tumorigenesis depending on the cell type and disease context. In colorectal cancer, we have previously shown that aberrantly high ESRP1 expression can drive tumor progression. In order to unveil the mechanisms by which ESRP1 can modulate cancer traits, we searched for proteins affected by modulation of Esrp1 in two human colorectal cancer cell lines, HCA24 and COLO320DM, by proteomics analysis. Proteins hosted by endogenous ESRP1 ribonucleoprotein complex in HCA24 cells were also analyzed following RNA-immunoprecipitation. Proteomics data were complemented with bioinformatics approach to exploit publicly available data on protein-protein interaction (PPI). Gene Ontology was analysed to identify a common molecular signature possibly explaining the pro-tumorigenic role of ESRP1. Interestingly, proteins identified herein support a role for ESRP1 in response to external stimulus, regulation of cell cycle and hypoxia. Our data provide further insights into factors affected by and entwined with ESRP1 in colorectal cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells

Ala

Manco

Mandili

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…It has been suggested that elevated production of IL-8 triggered by cell cycle and apoptosis regulator 2 under conditions of oxidative stress has a role in inflammation and progression of CC. 52 IL-12 is a heterodimeric pro-inflammatory cytokine with antitumor activity because it promotes cytotoxic T cell (CTL) responses and Th1 adaptive immunity. The polymorphisms in the IL12 gene, IL12Brs3212227 and IL12Ars568408 contribute to the risk of CC.…”

Section: Inflammation and CCmentioning

confidence: 99%

“…In addition to IL‐10, IL‐8 plays a causative role in acute inflammation. It has been suggested that elevated production of IL‐8 triggered by cell cycle and apoptosis regulator 2 under conditions of oxidative stress has a role in inflammation and progression of CC . IL‐12 is a heterodimeric pro‐inflammatory cytokine with antitumor activity because it promotes cytotoxic T cell (CTL) responses and Th1 adaptive immunity.…”

Section: Inflammation and CCmentioning

confidence: 99%

Pathogenic role of exosomes and microRNAs in HPV‐mediated inflammation and cervical cancer: A review

Nahand

Moghoofei

Salmaninejad

et al. 2019

Intl Journal of Cancer

187

108

View full text Add to dashboard Cite

Cervical cancer (CC) is the fourth most common cause of cancer death in women. The most important risk factor for the development of CC is cervical infection with human papilloma virus (HPV). Inflammation is a protective strategy that is triggered by the host against pathogens such as viral infections that acts rapidly to activate the innate immune response. Inflammation is beneficial if it is brief and well controlled; however, if the inflammation is excessive or it becomes of chronic duration, it can produce detrimental effects. HPV proteins are involved, both directly and indirectly, in the development of chronic inflammation, which is a causal factor in the development of CC. However, other factors may also have a potential role in stimulating chronic inflammation. MicroRNAs (miRNAs) (a class of noncoding RNAs) are strong regulators of gene expression. They have emerged as key players in several biological processes, including inflammatory pathways. Abnormal expression of miRNAs may be linked to the induction of inflammation that occurs in CC. Exosomes are a subset of extracellular vesicles shed by almost all types of cells, which can function as cargo transfer vehicles. Exosomes contain proteins and genetic material (including miRNAs) derived from their parent cells and can potentially affect recipient cells. Exosomes have recently been recognized to be involved in inflammatory processes and can also affect the immune response. In this review, we discuss the role of HPV proteins, miRNAs and exosomes in the inflammation associated with CC.

show abstract

“…In CCAR2-deficient cells, the expression of IL-8 is upregulated by activating the transcription factor AP-1. This is also related to a shorter survival of CC patients [16]. Most somatic mutations that occur in a cell are biologically neutral, which means they will not trigger cancer progression.…”

Section: Cytokines: a Cause Of Inflammation In Hpv-mediated CCmentioning

confidence: 99%

Pathogenesis of Hepatitis-B Virus-Related Hepatocellular Carcinoma and Human Papillomavirus-Associated Cervical Cancer

Zhao¹

2022

HSET

View full text Add to dashboard Cite

Cancer, which can be explained as malignant tumors and neoplasms, is one of the main factors of human mortality and greatly obstructs the extension global human life span. There are various human cancers induced by viruses. Hepatocellular carcinoma (HCC) and cervical cancer (CC) are two common cancers related to viruses. The pathogenesis of these carcinogenic viruses has been studied for a long period of time, and some progress has been made. Hepatitis B virus (HBV) infection functions as a promoter of hepatocellular carcinoma occurrence. The integration of HBV DNA into the host genome is one of the important factors of the development of hepatocellular carcinoma. Besides, miRNA plays an important part in HBV ampilification and the progression of HBV-related hepatocellular carcinoma. Another cancer-inducing virus, human papillomavirus (HPV) is highly related to cervical cancer, as the long-term chronic inflammation due to HPV infection can lead to the progression of cervical cancer. Apart from this, APOBECs also give rise to the progression of HPV-induced cervical cancer. This essay will estimate the pathogenesis of HBV-associated hepatocellular carcinoma, such as HBV DNA integration, microRNA. Meanwhile the pathogenesis of HPV-related cervical cancer, such as inflammation, APOBEC3, will also be noted.

show abstract

CCAR2 negatively regulates IL-8 production in cervical cancer cells

Cited by 5 publications

References 59 publications

Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells

Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells

Pathogenic role of exosomes and microRNAs in HPV‐mediated inflammation and cervical cancer: A review

Pathogenesis of Hepatitis-B Virus-Related Hepatocellular Carcinoma and Human Papillomavirus-Associated Cervical Cancer

Contact Info

Product

Resources

About