CD10-A new prognostic stromal marker in breast carcinoma, its utility, limitations and role in breast cancer pathogenesis

Jana, Sayantan; Jha, Bharti M; Patel, C. A.; Jana, Dipan; Agarwal, Aditi

doi:10.4103/0377-4929.142639

Cited by 27 publications

(52 citation statements)

References 26 publications

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“…16 Jana SH et al also observed similar results. 9 In the present study 73% (22 out of 30) of the cases showed positivity for CD10 in the stroma, of which 46% (14) cases were strongly positive and 27% (8) were weakly positive. Only two cases of strong positivity for CD10 were noted in the adjacent normal breast parenchyma.…”

supporting

confidence: 49%

“…CD10 act as a stem cell regulator in the breast and prevents uncontrolled proliferation of stem cells. 9 In most of the normal breast tissue, except a small population of stromal cells has been shown to express CD10, there are no CD10 positive stromal cells. 16,17 In gastric carcinoma, CD10 positive stromal cells are correlated with vascular invasion and metastasis.…”

Section: Discussionmentioning

confidence: 97%

“…Jana SH et al study shows stromal CD10 positivity in 65% cases of grade III invasive ductal carcinoma of breast and the association is statistically significant. 9 Makretsov et al study shows 59% positivity for stromal CD10 in grade III cases.…”

mentioning

confidence: 93%

“…CD10 act as a stem cell regulator in the breast and prevents uncontrolled proliferation of stem cells. 9 It is expressed in breast myoepithelial cells, lymphoid stem cells, neutrophils, and other epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

“…23 It also explains increased expression of stromal CD10 in high grade undifferentiated breast carcinomas. 9 Recent studies indicate EMT has a role in invasiveness and metastasis of carcinoma.…”

mentioning

confidence: 99%

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An analysis of stromal expression of CD10 in invasive ductal carcinoma of breast and its correlation with histological grade

et al. 2017

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Background: Breast cancer is one of the most common cancers among women in India. Stroma has an important role in the pathogenesis of carcinoma of breast. Stromal marker can be novel marker for assessing the prognosis of breast cancer.Methods: With the representative sections of 30 invasive ductal carcinoma of breast NOS type Hematoxylin and eosin staining was done. Immunohistochemistry was done with CD10. CD10 expression in stroma in cases and control slides were studied and statistically analyzed with histopathological grade.Results: 46% (14 out of 30) of cases showed strong positivity for stromal CD10. Only two cases of strong positivity for CD10 were noted in the adjacent normal breast parenchyma. Stromal expression of CD10 had a statistically significant association with breast carcinoma than in control slides, p value is 0.002. 77% (10 out of 13) of CD10 positive cases were high grade carcinomas. Association of CD10 expression with high grade tumour was statistically significant (p value is 0.04 which is less than 0.05). No association was found with mean age.Conclusions: As the grade of breast carcinoma increases the stromal expression of CD10 is increased. Stromal CD10 expression is directly correlated with higher tumour grade. CD10 could be used as novel prognostic marker and used to develop newer drugs.

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supporting

confidence: 49%

Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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