CD14 gene polymorphism is not associated with asthma but rather with bronchial obstruction and hyperreactivity in Slovenian children with non-atopic asthma

Perin, Petra; Berce, Vojko; Potočnik, Uroš

doi:10.1016/s0954-6111(11)70012-9

Cited by 12 publications

(8 citation statements)

References 31 publications

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“…The number of cases varied from 10 to 644, and controls from 115 to 1858 subjects. CD14 rs2569190 polymorphism, also known as C-260T or C-159T, was studied in 16 studies [10,12,13,19-21,34,36-40,42-45]. Only one study found an association of this polymorphism with childhood asthma, showing an association of the T allele with decreased asthma severity (Table 3) [19].…”

Section: Resultsmentioning

confidence: 99%

A systematic review of CD14 and toll-like receptors in relation to asthma in Caucasian children

Klaassen

Thönissen

Eys

et al. 2013

All Asth Clin Immun

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The aetiology of childhood asthma is complex. An early dysfunction in the immunological development of the innate immune system in combination with environmental factors possibly triggers asthma. CD14 and toll-like receptors are important components of the innate immune system. The aim of this systematic review was to obtain a better insight into the relation between CD14 and toll-like receptors and childhood asthma in Caucasians. We searched PubMed and EMBASE for relevant articles. In total, 44 articles were included. The quality of the selected studies was independently assessed by the first two authors using the Newcastle-Ottawa quality assessment scale. Toll-like receptor 2, toll-like receptor 6, toll-like receptor 9, and toll-like receptor 10 appear to have some association with childhood asthma in Caucasians. The evidence for a relation of CD14 with childhood asthma is limited. In conclusion, there is no convincing evidence yet for a role of CD14 and toll-like receptors in relation to childhood asthma. Future studies should include haplotype analysis and take environmental factors into account to further clarify the role of CD14 and toll-like receptors on childhood asthma.

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Section: Resultsmentioning

confidence: 99%

A systematic review of CD14 and toll-like receptors in relation to asthma in Caucasian children

Klaassen

Thönissen

Eys

et al. 2013

All Asth Clin Immun

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“…A total of 7 case–control studies [11,17,22,23,33,36,47] conducted among nonatopic asthma were included in this meta-analysis. Overall, the pooled results indicated that there was no significant relationship of CD14 −159C/T and nonatopic asthma risk in dominant model (TT+TC vs CC: OR = 1.05, 95% CI = 0.82–1.33, P = 0.700) (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…However, the data have yielded conflicting results. [11,21,30–36] Therefore, we performed this updated meta-analysis to investigate the more precise association between the CD14 −159C/T variant and asthma risk.…”

Section: Discussionmentioning

confidence: 99%

“…The results were consistent with some recent studies. [11,21,23,36] However, this may be due to the mediating environmental conditions and the unclear relationship between −159C/T variant and sCD14 levels. It was demonstrated that the association of the −159C/T polymorphism and asthma is dependent on different degrees of endotoxin exposure: individuals with TT genotypes were protective for asthma at low levels of endotoxin, but were at risk at high levels of endotoxin exposure.…”

Section: Discussionmentioning

confidence: 99%

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Association of CD14 −159 (−260C/T) polymorphism and asthma risk

Yang

Zhou

et al. 2016

Medicine

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Background:It has been reported that the cluster of differentiation 14 (CD14) gene −159C/T variant may be associated with asthma risk. However, some studies yielded conflicting results. Therefore, a comprehensive meta-analysis was designed to assess the precise association.Methods:A systematic search in PubMed, Embase (Ovid), China National Knowledge Internet (CNKI), and Wan fang databases was conducted up to August 15, 2015. Odds ratio (OR) and 95% confidence interval (CI) were used to pool the effect size. We used I2 to assess heterogeneity, and a funnel plot and Egger test to assess publication bias.Results:In total, 34 studies involving 15,641 subjects were included in this meta-analysis. There was a statistically significant association between CD14 −159C/T polymorphism and asthma risk observed in dominant model (TT+TC vs CC: OR = 0.86, 95% CI = 0.77–0.97, P = 0.012) and codominant model (TC vs CC: OR = 0.88, 95% CI = 0.78–0.99, P = 0.035) in adults. However, there may be no significant association between CD14 159C/T and atopic and nonatopic asthma risk.Conclusion:In summary, the overall results suggested that the CD14 −159C/T variant may decrease the risk of asthma susceptibility in adults. However, no significant association between CD14 159C/T and atopic and nonatopic asthma susceptibility was identified. More studies with larger sample size are needed to validate the findings from this study.

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“…Asthmatic (allergic and non-allergic) patients, children aged between 7 and 18 years with mild or moderate persistent asthma treated after 01.01.2008 in the University Medical Centre Maribor were enrolled in the study, considering inclusion and exclusion criteria (Perin et al, 2011). Asthma was diagnosed according to NAEPP (National Asthma Education and Prevention Program) and ATS (American Thoracic Society) criteria.…”

Section: Study Subjectsmentioning

confidence: 99%

Reference genes for real-time qPCR in leukocytes from asthmatic patients before and after anti-asthma treatment

Kozmus

Potočnik

2015

Gene

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CD14 gene polymorphism is not associated with asthma but rather with bronchial obstruction and hyperreactivity in Slovenian children with non-atopic asthma

Abstract: Our results suggest that CD14 is associated with asthma severity in Slovenian children with non-atopic asthma.

Cited by 12 publications

References 31 publications

A systematic review of CD14 and toll-like receptors in relation to asthma in Caucasian children

A systematic review of CD14 and toll-like receptors in relation to asthma in Caucasian children

Association of CD14 −159 (−260C/T) polymorphism and asthma risk

Reference genes for real-time qPCR in leukocytes from asthmatic patients before and after anti-asthma treatment

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