CD147 Expression in Advanced Cutaneous Squamous Cell Carcinoma

Sweeny, Larissa; Dean, Nichole R.; Frederick, John W.; Magnuson, J. Scott; Carroll, William R.; Hartman, Yolanda E.; Desmond, Renee; Rosenthal, Eben L.

doi:10.1002/lary.22252

Cited by 5 publications

(6 citation statements)

References 18 publications

(33 reference statements)

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“…52 Some studies also indicate that CD147 is associated with an aggressive phenotype, increasing tumor proliferation, 53 migration, 54 invasion 55 and metastization, 56 as well as with poor survival in HNSCC. 36,57,58 In this study, no associations were found between CD147 and tumor aggressiveness or overall survival. GLUT1 mediates the important mechanisms involved in cellular glucose influx, allowing cells to proliferate and survive.…”

Section: Discussioncontrasting

confidence: 59%

“…The plasma membrane expression of all proteins studied support their activity. Since most of the molecules here in studied, with the exception of MCT2, are involved in the cancer hyperglycolytic phenotype, one can assume that OCC have a highly glycolytic phenotype, which is supported by previous 27,[36][37][38][39][40] studies and by the applicability of FdG-PET scan in this type of cancer. [41][42][43] Moreover, since GLUT1 was present in 96.1% of tumor samples, this reinforces the presence of a glycolytic metabolism.…”

Section: Discussionsupporting

confidence: 56%

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Prognostic significance of monocarboxylate transporter expression in oral cavity tumors

et al. 2016

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Section: Discussioncontrasting

confidence: 59%

Section: Discussionsupporting

confidence: 56%

Prognostic significance of monocarboxylate transporter expression in oral cavity tumors

et al. 2016

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“…Staining for CD147, MCT1 and MCT4, among other markers, has been performed in pathological studies to determine the significance of these proteins in cutaneous SCC. Indeed, while these proteins have been suggested to serve as biomarkers of SCC and as targets of treatment, few studies to date have used antibodies against autophagy‐related molecules . In the present study, we performed immunohistochemical staining using LC3 and p62 antibodies in cutaneous SCC specimens resected at our hospital, collated the results and conducted statistical analysis to determine the significance of LC3 and p62 expression.…”

Section: Discussionmentioning

confidence: 98%

Inverse correlation between microtubule‐associated protein 1A/1B‐light chain 3 and p62/sequestosome‐1 expression in the progression of cutaneous squamous cell carcinoma

Yoshihara

Takagi

Ueno

et al. 2014

The Journal of Dermatology

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The expression of autophagy-related markers has occasionally been reported to correlate with the clinical stage of disease in patients with solid cancer, indicating autophagy activation. However, there have been no such reports for cutaneous squamous cell carcinoma. In this study, we investigated the expression levels of two autophagy-related markers, microtubule-associated protein IA/IB light chain 3 (LC3) and p62/sequestosome-1 (p62), in cutaneous squamous cell carcinoma specimens and assessed their correlation to clinicopathological factors in patients with this type of cancer. As a marker of the autophagosome, LC3 expression increases with autophagosome formation/accumulation, whereas p62 expression decreases due to selective degradation via autophagy. We performed immunostaining for LC3 and p62 in 50 cutaneous squamous cell carcinoma specimens obtained from patients treated by surgical resection, counted the number of cells that showed positive staining, and calculated the percentage of positive cells per low-power microscopic field. We next investigated the correlations between the expression levels of these markers and various clinicopathological factors. The results indicated that LC3 expression increased significantly with advanced clinical stage (P < 0.001) and increased tumor diameter (P = 0.046). By contrast, the expression of p62 decreased significantly with advanced clinical stage (P < 0.001) and increased tumor diameter (P = 0.001). These results suggest that autophagy becomes activated during disease progression in patients with cutaneous squamous cell carcinoma.

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“…High emmprin expression in the tumor cells is associated with poor prognosis in SCC of the oral cavity, skin, and hypopharynx 29‐31 . The expression of CD73 not only in tumor cells but also in stroma affects prognosis.…”

Section: Discussionmentioning

confidence: 99%

Highly expressed tumoral emmprin and stromal CD73 predict a poor prognosis for external auditory canal carcinoma

et al. 2020

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Squamous cell carcinoma of the external auditory canal (SCC‐EAC) is rare and has a poor prognosis. The SCC‐EAC cases with high‐grade tumor budding (TB) or poorly differentiated clusters (PDCs) are associated with shorter survival than those with low‐grade TB or PDCs. Extracellular matrix metalloproteinase inducer (emmprin) is a protein expressed in tumor cells that stimulates the production of MMP‐2 by stromal fibroblasts to facilitate tumor invasion. Recently, we reported that emmprin forms a complex with CD73 to regulate MMP‐2 production from fibroblasts in vitro. Here, we examined the association of emmprin and CD73 expression with TB or PDCs as well as with survival in 34 biopsy specimens of SCC‐EAC patients. High tumoral emmprin expression was associated with highgrade TB, whereas high stromal CD73 expression was associated with high‐grade PDCs. Furthermore, concurrent elevated expression of tumoral emmprin and stromal CD73 was determined to be an independent poor prognostic factor. In immunoprecipitation analyses, complex formation between emmprin and CD73 was demonstrated in vitro. Production of MMP‐2 from fibroblasts was more abundant when cocultured with tumor cells than from fibroblasts cultured alone. Furthermore, MMP‐2 production was reduced by the transfection of CD73 siRNA in fibroblasts cocultured with tumor cells. The colocalization of emmprin and CD73 was enhanced in not only the peripheral cells of the tumor cell clusters that interact with fibroblasts but also in the cells of intratumor clusters. Overall, this study provides novel insights into the roles of emmprin, CD73, and MMP‐2 in tumor invasiveness.

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CD147 Expression in Advanced Cutaneous Squamous Cell Carcinoma

Cited by 5 publications

References 18 publications

Prognostic significance of monocarboxylate transporter expression in oral cavity tumors

Prognostic significance of monocarboxylate transporter expression in oral cavity tumors

Inverse correlation between microtubule‐associated protein 1A/1B‐light chain 3 and p62/sequestosome‐1 expression in the progression of cutaneous squamous cell carcinoma

Highly expressed tumoral emmprin and stromal CD73 predict a poor prognosis for external auditory canal carcinoma

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