CD15 immunostaining improves placental diagnosis of fetal hypoxia

Seidmann, Larissa; Kamyshanskiy, Yevgeniy; Wagner, Daniel; Zimmer, S; Roth, Wilfried

doi:10.1016/j.placenta.2021.01.016

Cited by 7 publications

(8 citation statements)

References 26 publications

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“…Moreover, CD15 immunoreactivity was also used as and as biomarker of foetal hypoxia in accordance of the study of Seidman et al [ 10 ].…”

Section: Diagnostic Assessmentmentioning

confidence: 87%

“…This marker is useful to evaluate granulocytic inflammation in the umbilical cord [ 9 ] as well as in the endothelial cells of placental tissue can be indicate distal vascular immaturity and risk of foetal hypoxia/asphyxia [ 10 ]. The immunoreactivity for this antibody in our study demonstrated that there was not severe foetal hypoxia/asphyxia risk for newborns or distal vascular immaturity.…”

Section: Discussionmentioning

confidence: 99%

“…In the Case 1, we did not observe immunoreactivity for CD 15 in the arteries of the stem villi and in the capillaries of the terminal villi (Fig. 5 a) (Table 4 ), as well as in the placenta of a healthy pregnancy (Case control), demonstrating that there was no risk of foetal hypoxia/asphyxia in this case of mild disease [ 10 ] (Table 1 ). In the remaining four cases, which corresponded to mild and more severe disease (Table 1 ), the expression of CD15 was low (Fig.…”

Section: Pathological Findingsmentioning

confidence: 96%

“…In this case, as well as in all remainig cases, to better quantify the risk of hypoxia/asphyxia for newborn, we performed a immunohistochemical study, using CD15 immunoreactivity, in line with the study of Seidmann et al [ 10 ].…”

Section: Pathological Findingsmentioning

confidence: 99%

“…Therefore in none of mild or more severe COVIDs we observed risk of severe foetal hypoxia/asphyxia and distal vascular immaturity (Table 4 ) (Fig. 5 ) [ 10 ].

Fig.…”

Section: Pathological Findingsmentioning

confidence: 99%

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COVID-19 in pregnancy: placental pathological patterns and effect on perinatal outcome in five cases

et al. 2021

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Introduction COVID-19, the disease caused by the novel coronavirus SARS-CoV-2, is a severe systemic thrombotic syndrome that emerged in 2019, with an ensuing pandemic. To evaluate the impact of this disease on placental tissue and perinatal outcome, histological, immunohistochemical and ultrastructural analyses of placental tissue were performed for five cases of pregnant women with COVID-19. Case reports All five pregnant women in this series developed COVID-19 in late pregnancy. Two patients experienced respiratory distress, and computed tomography revealed signs of pneumonia, with bilateral involvement, multiple lobular and subsegmental areas of consolidation and ground-glass opacities. Histological studies of placental tissue revealed the presence of slight signs of maternal vascular underperfusion (MVUs) or foetal vascular underperfusion (FVUs) lesions and mild inflammatory lesions. CD15 immunoreactivity in the placental tissue was low in all cases, demonstrating that in these cases there was not severe foetal hypoxia/asphyxia risk for newborns or distal vascular immaturity. In all cases examined, ultrastructural analyses showed spherical-like coronavirus particles with an electron intermediate-density core as well as projections from the surface as spike-like structures in the syncytiotrophoblasts. At term, all of the women delivered newborns who were negative for SARS-CoV-2 by nasopharyngeal testing in their first day of life. All newborns were exclusively breastfed and were discharged on the 3rd day of life. Conclusions In conclusion, placental patterns in pregnancy due to COVID-19 in the late stage of gestation indicate no evidence of vertical trans-placental SARS-CoV-2 transmission or a significant impact on the perinatal outcome of newborns, in both mild and more severe cases.

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“…Moreover, CD15 immunoreactivity was also used as and as biomarker of foetal hypoxia in accordance of the study of Seidman et al [ 10 ].…”

Section: Diagnostic Assessmentmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Pathological Findingsmentioning

confidence: 96%

Section: Pathological Findingsmentioning

confidence: 99%

“…Therefore in none of mild or more severe COVIDs we observed risk of severe foetal hypoxia/asphyxia and distal vascular immaturity (Table 4 ) (Fig. 5 ) [ 10 ].

Fig.…”

Section: Pathological Findingsmentioning

confidence: 99%

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