CD22 and CD72 are inhibitory receptors dominantly expressed in B lymphocytes and regulate systemic autoimmune diseases

Tsubata, Takeshi

doi:10.1007/s00393-015-1577-2

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…CD22 was called inhibitory BCR co-receptors (39). Although some of other BCR co-receptors were expressed in other immune cell types such as dendritic cells, CD22 was dominantly expressed on B cells (40). Study demonstrated that CD22 could regulate B cell through both ligand-dependent and ligand-independent way (41).…”

Section: Discussionmentioning

confidence: 99%

IL-10-Producing B Cells Regulate T Helper Cell Immune Responses during 1,3-β-Glucan-Induced Lung Inflammation

Liu

Dai

et al. 2017

Front. Immunol.

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With the rapid development of industry and farm, fungi contamination widely exists in occupational environment. Inhalation of fungi-contaminated organic dust results in hypersensitivity pneumonitis. 1,3-β-Glucan is a major cell wall component of fungus and is considered as a biomarker of fungi exposure. Current studies showed that 1,3-β-glucan exposure induced lung inflammation, which involved uncontrolled T helper (Th) cell immune responses, such as Th1, Th2, Th17, and regulatory T cell (Treg). A recently identified IL-10-producing B cells (B10) was reported in regulating immune homeostasis. However, its regulatory role in hypersensitivity pneumonitis is still subject to debate. In our study, we comprehensively investigated the role of B10 and the relationship between B10 and Treg in 1,3-β-glucan-induced lung inflammation. Mice with insufficient B10 exhibited more inflammatory cells accumulation and severer pathological inflammatory changes. Insufficient B10 led to increasing Th1, Th2, and Th17 responses and restricted Treg function. Depletion of Treg before the onset of inflammation could suppress B10. Whereas, Treg depletion only at the late stage of inflammation failed to affect B10. Our study demonstrated that insufficient B10 aggravated the lung inflammation mediated by dynamic shifts in Th immune responses after 1,3-β-glucan exposure. The regulatory function of B10 on Th immune responses might be associated with Treg and IL-10. Treg could only interact with B10 at an early stage.

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Section: Discussionmentioning

confidence: 99%

IL-10-Producing B Cells Regulate T Helper Cell Immune Responses during 1,3-β-Glucan-Induced Lung Inflammation

Liu

Dai

et al. 2017

Front. Immunol.

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“…We also observed spleen-specific expression of B cell inhibitory co-receptors ( CD22, CD72, LY9 ), suggesting that multipotent progenitors reside in the spleen. These multipotent progenitors of the spleen stem cells could be differentiating to myeloid and erythroid lineage cells in addition to differentiation of the lymphoid lineage cells (primarily to B cells and to some extent to T cells) 44 .…”

Section: Resultsmentioning

confidence: 99%

Pseudo-grading of tumor subpopulations from single-cell transcriptomic data using Phenotype Algebra

Sengupta

Nelson

Bhattacharya

et al. 2022

Preprint

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Robust characterization of cellular phenotypes from single-cell gene expression data is of paramount importance in understanding complex biological systems and diseases. Single-cell RNA-seq (scRNA-seq) datasets are inherently noisy due to small amounts of starting RNA. Over the last few years, several methods have been developed to make single-cell analysis fast and efficient. Most of these methods are based on statistical and machine learning principles. In the current work, we describe SCellBOW, which encodes single-cell expression vectors as documents, thereby enabling the application of powerful language models. Beyond the identification of robust cell type clusters, our algorithm provides a latent representation of single-cells in a manner that captures the ‘semantics’ associated with cellular phenotypes. These representations,akaembeddings, allow algebraic operations such as ‘+’ and ‘-’. We use this hitherto unexplored utility to stratify cancer clones in terms of their aggressiveness and contribution to disease prognosis. Further, the application of SCellBOW to a scRNA-seq dataset comprising human splenocytes and matched peripheral blood mononuclear cells (∼5000 cells) identifies unknown cell states that bear significance in advancing our understanding of spleen biology.

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“…Simultaneously, it inhibits the corresponding B cell response through its intracellular immunoreceptor tyrosine-based inhibition motif (ITIM), effectively blocking TLR7-mediated activation of antibody production. 50 Finally, RT1-N2 belongs to the family of rat MHC class Ib molecules. Recent studies have demonstrated interactions with both inhibitory and activating Ly49 receptors, resulting in the specific expansion of allospecific NK cells.…”

Section: Discussionmentioning

confidence: 99%

Differential gene expression during recall of behaviorally conditioned immune enhancement in rats: a pilot study

Rueckels,

Picard-Mareau

2024

F1000Res

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Background: Behaviorally conditioned immune functions are suggested to be regulated by bidirectional interactions between CNS and peripheral immune system via the hypothalamic-pituitary-adrenal (HPA) axis, sympathetic nervous system (SNS), and the parasympathetic nervous system (PNS). Since the current knowledge about biochemical pathways triggering conditioned immune enhancement is limited, the aim of this pilot study was gaining more insights into that. Methods: Rats were conditioned with camphor smell and poly I:C injection, mimicking a viral infection. Following stimulus re-exposure, animals were sacrificed at different time points, and neural tissues along the HPA axis was analyzed with a rat genome array together with plasma protein using Luminex analysis. Results: In the hypothalamus, we observed a strong upregulation of genes related to Wnt/β-catenin signaling (Otx2, Spp1, Fzd6, Zic1), monoaminergic transporter Slc18a2 and opioid-inhibitory G-protein Gpr88 as well as downregulation of dopaminergic receptors, vasoactive intestinal peptide Vip, and pro-melanin-concentrating hormone Pmch. In the pituitary, we recognized mostly upregulation of steroid synthesis in combination with GABAergic, cholinergic and opioid related neurotransmission, in adrenal glands, altered genes showed a pattern of activated metabolism plus upregulation of adrenoceptors Adrb3 and Adra1a. Data obtained from spleen showed a strong upregulation of immunomodulatory genes, chemo-/cytokines and glutamatergic/cholinergic neurotransmission related genes, as also confirmed by increased chemokine and ACTH levels in plasma. Conclusions: Our data indicate that in addition to the classic HPA axis, there could be additional pathways as e.g. the cholinergic anti-inflammatory pathway (CAIP), connecting brain and immune system, modulating and finetuning communication between brain and immune system.

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CD22 and CD72 are inhibitory receptors dominantly expressed in B lymphocytes and regulate systemic autoimmune diseases

Cited by 5 publications

References 24 publications

IL-10-Producing B Cells Regulate T Helper Cell Immune Responses during 1,3-β-Glucan-Induced Lung Inflammation

IL-10-Producing B Cells Regulate T Helper Cell Immune Responses during 1,3-β-Glucan-Induced Lung Inflammation

Pseudo-grading of tumor subpopulations from single-cell transcriptomic data using Phenotype Algebra

Differential gene expression during recall of behaviorally conditioned immune enhancement in rats: a pilot study

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