CD29 of human umbilical cord mesenchymal stem cells is required for expansion of CD34⁺ cells

Abstract

CB CD34(+) cells co-cultured with CD29-deficient hUCMSCs gave rise to all major haematopoietic lineages, but failed to engraft long term.

Adaptive Regulation of Osteopontin Production by Dendritic Cells Through the Bidirectional Interaction With Mesenchymal Stromal Cells

“…For example, CD58 and CD54 play an important role in MSC/T cells interaction ( 50 ). Similarly, CD44 and CD29 are involved in the contact of human hematopoietic progenitor cells and MSCs ( 51 , 52 ). By the use of blocking monoclonal antibodies, it was possible to show that resting MSCs upregulate OPN production by a cell–cell contact mechanism involving the adhesion molecule CD29; other membrane proteins, such as CD44, CD54, and CD58, were not apparently involved in OPN production.…”

Therapeutic Use of Mesenchymal Stromal Cells: The Need for Inclusive Characterization Guidelines to Accommodate All Tissue Sources and Species

“…CD29, integrin beta-1, is a cell surface receptor that is involved in cell adhesion. CD29 has been found to be “highly” expressed (≥95%) on MSCs derived from human (Hu et al, 2003 ; Le Blanc et al, 2003 ; Wexler et al, 2003 ; Brooke et al, 2008 ; Pruszak et al, 2009 ; Park and Patel, 2010 ; Aldridge et al, 2012 ; Al-Nbaheen et al, 2013 ; Guan et al, 2014 ; Yang et al, 2014 ; Alrefaei et al, 2015 ; Katsiani et al, 2016 ; Van Pham et al, 2016 ; Togarrati et al, 2018 ; Kaviani et al, 2019 ), rat (Wu et al, 2009 ; Walker et al, 2010 ; Song et al, 2014 ; Davies et al, 2015 ; Suto et al, 2017 ), equine (Ranera et al, 2011 ; Alipour et al, 2015 ; Esteves et al, 2017 ; Zahedi et al, 2017 ; Gale et al, 2019 ; Lepage et al, 2019 ), canine (Filioli Uranio et al, 2011 ; Choi et al, 2013 ; Ivanovska et al, 2017 ), mouse (Meirelles Lda and Nardi, 2003 ; Ahmed et al, 2017 ), porcine (Ock et al, 2010 ; Lee et al, 2015 ; Wiater et al, 2018 ), buffalo (Deng et al, 2018 ), rabbit (Lee et al, 2013 ; Kovac et al, 2017 ), bovine (Corradetti et al, 2013 ; de Moraes et al, 2016 ), and chickens (Bai et al, 2013 ). Evidence suggests that CD29 expression may be involved with MSC migration along with CD73 (Ode et al, 2011 ).…”

Application of antibody-conjugated small intestine submucosa to capture urine-derived stem cells for bladder repair in a rabbit model

“…Isolated from urine samples, subpopulations of the USCs are characterized by distinct cell morphology, various potential for proliferation and differentiation [ 33 ], similar clone-forming efficiency and high level of CD29 expression [ 34 ]. Also known as Integrin beta 1, an adhesion molecule, the CD29 can bind with a variety of ligands and play an important role in the mobilization, homing, migration and differentiation of stem cells as well as mediation of niche interactions [ [72] , [73] , [74] , [75] , [76] , [77] ]. As a surface marker for the MSCs, CD29 is essential for cell adhesion and recognition in a variety of biological processes including embryogenesis, tissue repair and immune response [ 78 , 79 ].…”