2011
DOI: 10.1002/iub.549
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CD38 through the life of a murine B lymphocyte

Abstract: SummaryCD38 is a 45 kDa transmembrane receptor expressed in B lymphocytes and other cells from the immune system. It is involved in apoptosis, cell activation, differentiation, and proliferation. CD38 has been used extensively to classify various subpopulations of lymphocytes in both humans and mice. It has also been used as a marker of poor prognosis in some lymphoid pathologies. However, CD38 is not a marker but rather an ectoenzyme and a receptor, where it performs several functions. The CD38 signaling path… Show more

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Cited by 28 publications
(28 citation statements)
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“…). Multidimensional analysis of B cells was based on the expression of B220 (pan‐B cell marker in the mouse) , CD38 (highly expressed on mature and memory B cells, while it is reduced to an intermediate expression in germinal center B cells) , GL7 and CD95 (coexpressed by B cells involved in the GC reaction) , CD73 (memory B cells) , IgG1 and IgM (B cell receptors (BCR) in switched or unswitched B cells, respectively) , TACI and CD138 (coexpressed by terminally differentiated PCs) and CXCR4 (chemokine receptor involved in long‐lived PCs homing into bone marrow niches) . The flow of the process (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…). Multidimensional analysis of B cells was based on the expression of B220 (pan‐B cell marker in the mouse) , CD38 (highly expressed on mature and memory B cells, while it is reduced to an intermediate expression in germinal center B cells) , GL7 and CD95 (coexpressed by B cells involved in the GC reaction) , CD73 (memory B cells) , IgG1 and IgM (B cell receptors (BCR) in switched or unswitched B cells, respectively) , TACI and CD138 (coexpressed by terminally differentiated PCs) and CXCR4 (chemokine receptor involved in long‐lived PCs homing into bone marrow niches) . The flow of the process (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…CD38 is a membrane-bound protein which is expressed on the surface of B-cells throughout their lifespan [20]. However, the expression of CD38 is highest on B1 B-cells [21].…”
Section: Discussionmentioning
confidence: 99%
“…In this regard it is important to point out the role of CD38 and RGS1 gene in the progression of B cells from the early stages to switched memory B cells [34][36].…”
Section: Discussionmentioning
confidence: 99%