2017
DOI: 10.1016/j.cyto.2017.08.004
|View full text |Cite
|
Sign up to set email alerts
|

CD4 effector T cell differentiation is controlled by IL-15 that is expressed and presented in trans

Abstract: T cells are both producers and consumers of cytokines, and autocrine cytokine signaling plays a critical role in T cell immunity. IL-15 is a homeostatic cytokine for T cells that also controls inflammatory immune responses. An autocrine role of T cell-derived IL-15, however, remains unclear. Here we examined IL-15 expression and signaling upon effector T cell differentiation in mice, and, surprisingly, found that CD4 T cells did not express IL-15. CD4 T cells lacked Il15 gene reporter activity, did not contain… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
43
0

Year Published

2018
2018
2022
2022

Publication Types

Select...
6
1
1

Relationship

2
6

Authors

Journals

citations
Cited by 32 publications
(45 citation statements)
references
References 58 publications
(89 reference statements)
2
43
0
Order By: Relevance
“…In ASYM plaques, we identified IL-15-IL15RA on CD4 + T cells, an interaction involved in cell proliferation, cell migration, and inhibition of apoptosis 126 . On the other hand, in SYM plaques IL-15-IL2RB on both CD4 + and CD8 + T cells could regulate Th1 reprogramming 127 and differentiation 128 , two functional phenotypes that emerged in SYM plaques by from our CyTOF and scRNA-seq analyses.…”
Section: Resultsmentioning
confidence: 88%
“…In ASYM plaques, we identified IL-15-IL15RA on CD4 + T cells, an interaction involved in cell proliferation, cell migration, and inhibition of apoptosis 126 . On the other hand, in SYM plaques IL-15-IL2RB on both CD4 + and CD8 + T cells could regulate Th1 reprogramming 127 and differentiation 128 , two functional phenotypes that emerged in SYM plaques by from our CyTOF and scRNA-seq analyses.…”
Section: Resultsmentioning
confidence: 88%
“…97 Therefore, rapamycin at moderate concentrations inhibits CD4 + Teff growth but promotes CD4 + Treg growth and function. 111,112 In contrast, IL-15 is necessary for optimal CD8 + Tregs expansion in vivo 113,114 and in vitro. 111,112 In contrast, IL-15 is necessary for optimal CD8 + Tregs expansion in vivo 113,114 and in vitro.…”
Section: Metabolic Activitymentioning
confidence: 99%
“…97 in vitro while they do in vivo. 111,112 In contrast, IL-15 is necessary for optimal CD8 + Tregs expansion in vivo 113,114 and in vitro. 3,54,61 In vitro expansion of CD8 + Tregs in the same conditions used to expand CD4 + Tregs has shown lower suppression activity in some cases but this may be related to the use of culture conditions that are optimal for CD4 + and not CD8 + Tregs.…”
Section: Metabolic Activitymentioning
confidence: 99%
See 1 more Smart Citation
“…Naïve CD4 + T cells were electronically sorted by gating on CD62L + CD44 lo CD25 − cells. Sorted cells were stimulated with platebound antibodies against CD3 and CD28 (each at 1 g/ml) for 5 days, as previously described (61). Cells were cultured for 5 days under nonskewing T H 0 conditions (medium alone) or were differentiated into T H 17 cells with human TGF1 (5 ng/ml; PeproTech), mouse IL-6 (30 ng/ml; BD Biosciences), antibody against mouse IL-4 (10 g/ml; BD Biosciences), and antibody against mouse IFN- (10 g/ml; BD Biosciences).…”
Section: In Vitro Cd4 + T Helper Differentiationmentioning
confidence: 99%