CD4<sup>+</sup>CD25<sup>high</sup> Treg cells in peripheral blood during remission and exacerbation of allergic asthma in children

Pumputiene, Ingrida; Ėmužytė, Regina; Šiaurys, Almantas; Tamosiunas, Vytas; Valiulis, Arūnas

doi:10.1111/j.1651-2227.2011.02241.x

Cited by 14 publications

(12 citation statements)

References 26 publications

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“…Many studies addressed predictors of remission or persistence of asthma from early childhood through adulthood (23)(24)(25)(26). Immunoregulatory parameters related to the outcome of childhood asthma have been widely discussed, however are not yet well established (4,7,10,19,27). Speci c observations in the present study, regarding immunology parameters, were surprising.…”

Section: Discussioncontrasting

confidence: 57%

“…A wide range of cell types and suppressive molecules are involved in induction and maintenance of tolerance. The forkhead transcription factor (Foxp3) expression in regulatory T cells (Tregs) plays a crucial role in maintaining immunological tolerance (4,5). The IL-2 receptor (CD25) and transferrin receptor (CD71) are activation markers of T and B cells, and their increased expression might re ect an increased activation state (3,6).…”

Section: Introductionmentioning

confidence: 99%

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Allergic rhinitis and house dust mite sensitization determine persistence of asthma in children.

Brzozowska

Woicka-Kolejwa

Jerzyńska

et al. 2020

Preprint

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Background: MAS study revealed that chronic course of asthma characterised by airway hyper-responsiveness and impairment of lung function at school age is determined by continuing allergic airway inflammation which begin in the first 3 years of life. Respiratory tract infections early in life, childhood allergic comorbidities, exposure to environmental determinants of asthma and active smoking may all contribute to increased risk of allergic disorders. While these correlations have been established, there is little understanding of the immunological mechanisms by which asthma develops into a persistent disease, or by which symptoms regress. Methods: Eighty patients were included into the analysis. Clinical and immunoregulatory predictors of asthma were analyzed. Results: Presence of mAPI criteria as well as the presence of house dust mite-allergy and allergic rhinitis at present, were associated with a reduced prevalence of asthma remission. The presence of increased eosinophil blood count in API (Asthma Predictive Index) criteria was associated with a lower expression of CD25 positive cells. Current presence of HDM-allergy was associated with a higher FeNO level and higher expression of CD25CD71 positive cells. Allergic rhinitis was associated with a higher expression of PPAR and CD25CD71 positive cells; in the same group of patients a lower expression of GARP positive cells were observed. Conclusions: Probability of persistence of childhood asthma was largely determined by the presence of allergic rhinitis and sensitization to HDM. Our results suggest natural remission of clinical symptoms of asthma in children are not fully related to immunoregulation processes. Additionally, API criteria are related to asthma persistence.

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Section: Discussioncontrasting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Allergic rhinitis and house dust mite sensitization determine persistence of asthma in children.

Brzozowska

Woicka-Kolejwa

Jerzyńska

et al. 2020

Preprint

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“…hi regulatory cells in atopic asthmatic children, both during remission and exacerbation [32]. They observed no significant correlation of CD4 +…”

Section: Cd25mentioning

confidence: 87%

“…Some authors have reported lower levels of Treg cells in asthma patients [31]. Pumputiene et al have recently studied CD4 + CD25 hi regulatory cells in atopic asthmatic children, both during remission and exacerbation [32]. They observed no significant correlation of CD4 + CD25 hi T cell percentages.…”

Section: Whole Blood Culturesmentioning

confidence: 97%

Immune response to Streptococcus pneumoniae in asthma patients: comparison between stable situation and exacerbation

Otero

Paz

Galassi

et al. 2013

Clinical and Experimental Immunology

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SummaryIn Argentina, more than 3 million people suffer from asthma, with numbers rising. When asthma patients acquire viral infections which, in turn, trigger the asthmatic response, they may develop subsequent bacterial infections, mainly by Streptococcus (S.) pneumoniae. This encapsulated Gram + bacterium has been considered historically a T cell-independent antigen. Nevertheless, several papers describe the role of T cells in the immune response to S. pneumoniae. We evaluated the response to S. pneumoniae and compared it to the response to Mycobacterium (M.) tuberculosis, a different type of bacterium that requires a T helper type 1 (Th1) response, in cells from atopic asthmatic children, to compare parameters for the same individual under exacerbation and in a stable situation whenever possible. We studied asthma patients and a control group of age-matched children, evaluating cell populations, activation markers and cytokine production by flow cytometry, and cytokine concentration in serum and cell culture supernatants by enzymelinked immunosorbent assay (ELISA). No differences were observed in gd T cells for the same patient in either situation, and a tendency to lower percentages of CD4 + CD25 hi T cells was observed under stability. A significantly lower production of tumour necrosis factor (TNF)-a and a significantly higher production of interleukin (IL)-5 was observed in asthma patients compared to healthy individuals, but no differences could be observed for IL-4, IL-13 or IL-10. A greater early activation response against M. tuberculosis, compared to S. pneumoniae, was observed in the asthmatic patients' cells. This may contribute to explaining why these patients frequently acquire infections caused by the latter bacterium and not the former.

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“…Objective quantitative data on children's independent mobility and physical activity are collected using current best practice epidemiological approaches. Advancing on earlier research [67,68], objective measurement of children's independently mobile trips have been quantified in detail, drawing from travel diary, GPS, and accelerometer data. Built environmental features have been objectively quantified utilizing a variety of tools, providing a detailed quantification of this factor in relation to children's activity and mobility.…”

Section: Discussionmentioning

confidence: 99%

Kids in the city study: research design and methodology

et al. 2011

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BackgroundPhysical activity is essential for optimal physical and psychological health but substantial declines in children's activity levels have occurred in New Zealand and internationally. Children's independent mobility (i.e., outdoor play and traveling to destinations unsupervised), an integral component of physical activity in childhood, has also declined radically in recent decades. Safety-conscious parenting practices, car reliance and auto-centric urban design have converged to produce children living increasingly sedentary lives. This research investigates how urban neighborhood environments can support or enable or restrict children's independent mobility, thereby influencing physical activity accumulation and participation in daily life.Methods/DesignThe study is located in six Auckland, New Zealand neighborhoods, diverse in terms of urban design attributes, particularly residential density. Participants comprise 160 children aged 9-11 years and their parents/caregivers. Objective measures (global positioning systems, accelerometers, geographical information systems, observational audits) assessed children's independent mobility and physical activity, neighborhood infrastructure, and streetscape attributes. Parent and child neighborhood perceptions and experiences were assessed using qualitative research methods.DiscussionThis study is one of the first internationally to examine the association of specific urban design attributes with child independent mobility. Using robust, appropriate, and best practice objective measures, this study provides robust epidemiological information regarding the relationships between the built environment and health outcomes for this population.

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CD4⁺CD25^high Treg cells in peripheral blood during remission and exacerbation of allergic asthma in children

Abstract: CD4+CD25(high) T-cell proportion in the peripheral blood of total CD4+T cells is not reduced in children with allergic IgE-mediated asthma and does not differ between disease remission and exacerbation.

Cited by 14 publications

References 26 publications

Allergic rhinitis and house dust mite sensitization determine persistence of asthma in children.

Allergic rhinitis and house dust mite sensitization determine persistence of asthma in children.

Immune response to Streptococcus pneumoniae in asthma patients: comparison between stable situation and exacerbation

Kids in the city study: research design and methodology

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CD4+CD25high Treg cells in peripheral blood during remission and exacerbation of allergic asthma in children

Abstract: CD4+CD25(high) T-cell proportion in the peripheral blood of total CD4+T cells is not reduced in children with allergic IgE-mediated asthma and does not differ between disease remission and exacerbation.

Cited by 14 publications

References 26 publications

Allergic rhinitis and house dust mite sensitization determine persistence of asthma in children.

Allergic rhinitis and house dust mite sensitization determine persistence of asthma in children.

Immune response to Streptococcus pneumoniae in asthma patients: comparison between stable situation and exacerbation

Kids in the city study: research design and methodology

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CD4⁺CD25^high Treg cells in peripheral blood during remission and exacerbation of allergic asthma in children