CD4 T cell count is inversely associated with lumbar spine bone mass in HIV-infected men under the age of 50 years

Kwak, Mi Kyung; Lee, E. J.; Park, J. W.; Park, S. Y.; Kim, B. J.; Kim, T. H.; Suh, Kyoil; Koh, Jung Min; Lee, S. H.; Byun, Dong Won

doi:10.1007/s00198-019-04942-7

Cited by 10 publications

(7 citation statements)

References 37 publications

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“…Generally, chronic inflammatory diseases are associated with bone resorption. HIV-infected men had low CD4 T cells, which is inversely associated with bone loss ( 55 ). Some studies suggest that T cells are not associated with bone mineral density in HIV-infected patients treated with combination antiretroviral therapy (cART) ( 56 ).…”

Section: The T Cells In the Regulation Of Various Osteoporosismentioning

confidence: 99%

Osteoimmunology: The Regulatory Roles of T Lymphocytes in Osteoporosis

et al. 2020

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Immune imbalance caused bone loss. Osteoimmunology is emerging as a new interdisciplinary field to explore the shared molecules and interactions between the skeletal and immune systems. In particular, T lymphocytes (T cells) play pivotal roles in the regulation of bone health. However, the roles and mechanisms of T cells in the treatment of osteoporosis are not fully understood. The present review aims to summarize the essential regulatory roles of T cells in the pathophysiology of various cases of osteoporosis and the development of T cell therapy for osteoporosis from osteoimmunology perspective. As T cell-mediated immunomodulation inhibition reduced bone loss, there is an increasing interest in T cell therapy in an attempt to treat osteoporosis. In summary, the T cell therapy may be further pursued as an immunomodulatory strategy for the treatment of osteoporosis, which can provide a novel perspective for drug development in the future.

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Section: The T Cells In the Regulation Of Various Osteoporosismentioning

confidence: 99%

Osteoimmunology: The Regulatory Roles of T Lymphocytes in Osteoporosis

et al. 2020

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“…Earlier studies have found that age older than 50 years, tobacco consumption, low BMI, and CD4 + lymphocytes < 350 cells/mL were associated with bone abnormalities in men [13,21]. Previously, it was hypothesized that HIV-positive patients under the age of 50 years may have a lower BMD compared to that of HIV-uninfected patients [22]. We did not nd an association between BMD and other risk factors, such as weight loss higher than 10% at HIV diagnosis, age, physical activity, or tobacco consumption.…”

Section: Discussionmentioning

confidence: 99%

“…Our study limitations lie in that, because it is a cross-sectional study, performed at a single site, the results cannot be extrapolated to different populations. We also did not measure the level of 25-hydroxyvitamin D (25-OF-D), which has a signi cant effect on bone [22].…”

Section: Discussionmentioning

confidence: 99%

Incidence of osteoporosis and osteopenia in men with HIV+ and a history of Kaposi sarcoma

Cornejo-Juárez

2022

Preprint

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Background: Low bone mineral density (BMD) is a common complication of chronic HIV infection, reported between 30%-67% for osteopenia, and between 15%-30% for osteoporosis. Kaposi Sarcoma (KS) is an angioproliferative disease, mediated by cytokines which contributes to inflammation. The objective was to assess the prevalence of BMD in a cohort of HIV+ men with a history of KS.Methods: A retrospective study was performed from January 2019 to March 2021, in men over the age of 40 years and/or with more than 3 years of antiretroviral drugs. Odds Ratios with 95% Confidence Intervals were calculated. P values of ≤0.05 were considered statistically significant. Results: Eighty-four patients were included; mean age was 45.9 ± 8.8 years, and mean time from HIV diagnosis was 9.7 ± 6.8 years. The median baseline CD4+ was 102 cells (IQR 40, 216), and the median viral load was 143 582 copies/ml (IQR 26 527, 341 500). At the time of Dual X-ray Absorptiometry, the median CD4+ count was 361 cell/mL (IQR 225, 518) and the HIV-viral load was undetectable in 80 patients (95.2%). Osteoporosis was documented in 23.8% and osteopenia in 53.6%. The analysis comparing main risk factors, including different ARV drugs for low BMD did not show statistical differences. In the multivariate analysis, NNTRI and disseminated KS were found as protective factors for low BMD. Conclusions: The low BMD reported in this cohort may be related to several risk factors, it is advisable to establish preventive measures for BMD loss, regardless of age.

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“…3 Liver disease, kidney dys-function, cardiovascular disease, diabetes mellitus, cancer, fractures and cognitive dysfunction are observed at earlier ages and more often in PLWHIV than in the uninfected population. 3 There are various studies which have shown that bone mineral density (BMD) decreases among PLWHIV, 4,5 while the risk of fragility fractures increases. 6,7 Reduced BMD is associated with multifactorial causes such as advanced age, white race, weight loss, low body mass index (BMI), smoking, using glucocorticoids, and changes in vitamin D metabolism.…”

Section: Introductionmentioning

confidence: 99%

“… 3 Liver disease, kidney dysfunction, cardiovascular disease, diabetes mellitus, cancer, fractures and cognitive dysfunction are observed at earlier ages and more often in PLWHIV than in the uninfected population. 3 There are various studies which have shown that bone mineral density (BMD) decreases among PLWHIV, 4 , 5 while the risk of fragility fractures increases. 6 , 7 …”

Section: Introductionmentioning

confidence: 99%

The evaluation of risk factors related to reduced bone mineral density in young people living with HIV

Aydın¹,

Ankaralı²,

Ergen³

et al. 2022

Afr H. Sci.

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Background: Low bone mineral density (BMD) is one of the comorbidities that develop in people living with HIV (PLWHIV). Objective: This study was conducted to review the frequency and risk factors of reduced BMD according to age in HIV-infected patients in Turkey. Material and Method: This retrospective cohort study included HIV-infected patients aged 18-50. Bone density was analysed using dual-energy X-ray absorptiometry (DXA) according to the Z-score in three different regions including the lumbar, total-hip and femoral-neck. Results: The study included 224 PLWHIV with a mean age of 35.84-7.54, and 59.8% were ART naive. Of the patients, 40.6% had lower BMD than expected at least in one of the three examined regions including the lumbar, total hip and femoral neck. The low BMD ratios were found respectively as 11.6%, 11.6% and 28.6% in the femoral neck, total hip and lumbar regions. According to the logistic regression model, a high body mass index (p=0.003) and HIV-RNA level of ≥100.000IU/ml during the diagnosis in the ART-naive group (p=0.008) were associated with reduced bone demineralization. The low BMD frequency was high in the group that received ART for <24 months (p=0.001). Conclusion: Performing bone demineralization screening in the naive and young patient group, independently from ART status prior to making the diagnosis of HIV is important for organizing the bone health improvement methods. Keywords: HIV infection; bone density; antiretroviral therapy.

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CD4 T cell count is inversely associated with lumbar spine bone mass in HIV-infected men under the age of 50 years

Cited by 10 publications

References 37 publications

Osteoimmunology: The Regulatory Roles of T Lymphocytes in Osteoporosis

Osteoimmunology: The Regulatory Roles of T Lymphocytes in Osteoporosis

Incidence of osteoporosis and osteopenia in men with HIV+ and a history of Kaposi sarcoma

The evaluation of risk factors related to reduced bone mineral density in young people living with HIV

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