Cd40 and Cd40 Ligand (Cd154) Are Coexpressed on Microvessels in Vivo in Human Cardiac Allograft Rejection1,2

Reul, Ross M.; Fang, James C.; Denton, Mark D.; Geehan, Christopher; Long, Catherine; Mitchell, Richard N.; Ganz, Patricia A.; Briscoe, David M.

doi:10.1097/00007890-199712270-00025

Cited by 114 publications

(72 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In cardiac allografts, CD154 expression tended to be focal and predominately expressed on recipient graft infiltrating lymphocytes, but also to a less extent on donor endothelial cells (8). In renal allografts the expression of CD80, CD86 and CD154 appear to follow a pathologically linked pattern (15).…”

Section: Discussionmentioning

confidence: 94%

“…A number of investigators have previously shown increased expression of the costimulatory markers at the time of ACR (5,(8)(9)(10)(11)(15)(16)(17). In cardiac allografts, CD154 expression tended to be focal and predominately expressed on recipient graft infiltrating lymphocytes, but also to a less extent on donor endothelial cells (8).…”

Section: Discussionmentioning

confidence: 99%

“…CD154 protein expression is a dynamic process and was initially thought to be expressed exclusively on activated T cells. Recent reports have documented a wide cellular distribution of CD154 expression on APCs, eosinophils, natural killer (NK) cells, B cells, platelets, endothelial cells, reneal tubular epithelium, and smooth muscle cells (8,10,(20)(21)(22)(23)(24). The endothelium is thought to play a critical role in mediating the cell-mediated allo-immune response through the expression of cell-surface molecules that promote the recruitment and activation of lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

“…Antibodies that block the CD28-CD80/86 and CD40-CD154 costimulatory pathways have been shown in animal transplant models, including primates, to induce long-term unresponsiveness of T cells to alloantigens (3,4). Clinical studies have demonstrated an up regulation of intragraft CD80, CD86 and CD154 costimulatory molecule expression during episodes of acute renal and cardiac allograft rejection (5)(6)(7)(8). Similarly, enhanced CD154 expression has been demonstrated in renal and liver allografts with histological evidence of chronic rejection (9-11).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Analysis of Intragraft Gene and Protein Expression of the Costimulatory Molecules, CD80, CD86 and CD154, in Orthotopic Liver Transplant Recipients

Bartlett¹,

McCall²,

Ameratunga³

et al. 2003

American Journal of Transplantation

View full text Add to dashboard Cite

CD40-CD154 and/or CD28-CD80/86 costimulatory blockade induces long-term allograft survival in numerous animal models. Studies examining the expression of costimulatory molecules during acute cellular rejection (ACR) have been limited to renal and cardiac allografts.The aim of this study was to describe the relationship between intragraft costimulatory molecule expression in OLT recipients and ACR. Forty-five liver biopsies were obtained at reperfusion and day 7. Gene and protein expression of CD80, CD86 and CD154 were analyzed by RT-PCR and immunohistochemistry. CD154 protein expression was present in 13 of 18 patients with a RAI score of 4, but in only two of 14 patients with a RAI score of <4. There was a strong association between the RAI score and the presence of CD80 and CD154 immunoreactivity. CD86 protein expression did not correlate with the severity of ACR. In reperfusion biopsies CD154, but not CD80 or CD86, protein expression correlated with the total ischaemic time. There was no association between expression of costimulatory molecule genes and ACR.In conclusion, we have demonstrated an association between CD154 and CD80 protein expression and ACR in orthotopic liver allografts.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Analysis of Intragraft Gene and Protein Expression of the Costimulatory Molecules, CD80, CD86 and CD154, in Orthotopic Liver Transplant Recipients

Bartlett¹,

McCall²,

Ameratunga³

et al. 2003

American Journal of Transplantation

View full text Add to dashboard Cite

show abstract

“…Rejet de greffe L'intervention du CD154 a été indirectement suggérée par la démons-tration de l'augmentation de l'expression du CD40 sur l'endothélium des rejets de greffons [37]. Le lien entre CD154 plaquettaire et rejet de greffe doit cependant encore être précisé.…”

Section: Compétence Immunologique Du Cd154 Plaquettaireunclassified

Le CD154 plaquettaire : Une nouvelle interface dans l’hémostase et la réaction inflammatoire

et al. 2005

View full text Add to dashboard Cite

Les plaquettes sanguines sont des éléments figurés du sang provenant de la fragmentation du cytoplasme des mégacaryocytes spécialisés dans la formation du clou hémostatique conduisant à l'arrêt du saignement [1][2][3]. La place de la plaquette dans la réaction inflammatoire a fait l'objet de très nombreux travaux que l'on pourrait schématiser en deux axes, l'un reflétant la participation directe des médiateurs pro-inflammatoires stockés dans les plaquettes et libérés lors de leur activation, l'autre les liens indirects entre activation plaquettaire et réaction inflammatoire, via le système du complément, la cascade des kinines, etc. Différen-tes revues ont été publiées concernant plaquettes et réaction inflammatoire, auxquelles nous renvoyons le lecteur [4]. La mise en évidence récente de l'expression du CD154 par les plaquettes a repositionné ces derniè-res dans la coagulation, la réaction inflammatoire et la réponse immunitaire. CD154 : une molécule indispensable à l'activation des lymphocytes BLe couple CD154/CD40 Le CD154 est une glycoprotéine membranaire de 30 kDa à 33 kDa présentant des homologies de séquence avec les molécules de la famille du tumor necrosis factor (TNF). Les protéines membranaires de cette famille sont > Il a récemment été montré que les plaquettes sanguines exprimaient le CD154 (ligand du CD40), qu'elles extériorisent à leur surface lors de leur activation. Cette découverte a eu des consé-quences importantes sur la compréhension de la biologie de la plaquette. D'une part, le CD154 intervient dans la stabilisation du thrombus plaquettaire. D'autre part, l'interaction des plaquettes avec les cellules exprimant le récepteur CD40 a mis en évidence de nouvelles interfaces liant les plaquettes à la réaction inflammatoire, la coagulation et le remodelage de la matrice extracellulaire. Cela est tout particulièrement vrai pour les interactions plaquettes/vaisseaux et le CD154 plaquettaire joue un rôle clé dans la maladie athéromateuse. Enfin, l'expression du CD154 confère aux plaquettes une compé-tence immunologique, leur faisant jouer un rôle potentiel dans la réponse immune ou dans les pathologies associées à une auto-immunisation antiplaquettaire comme le purpura thrombopé-nique idiopathique. Article disponible sur le site

show abstract

CD40-CD40 ligand

Kooten

Banchereau²

2000

Journal of Leukocyte Biology

1,297

1,199

View full text Add to dashboard Cite

Cd40 and Cd40 Ligand (Cd154) Are Coexpressed on Microvessels in Vivo in Human Cardiac Allograft Rejection1,2

Abstract: Both CD40 and CD40L are expressed in vivo on infiltrating leukocytes and on microvascular endothelium in human cardiac allograft rejection. We suggest that endothelial cell CD40 and CD40L play a role in human cell-mediated immune responses such as cardiac allograft rejection.

Cited by 114 publications

References 31 publications

Analysis of Intragraft Gene and Protein Expression of the Costimulatory Molecules, CD80, CD86 and CD154, in Orthotopic Liver Transplant Recipients

Analysis of Intragraft Gene and Protein Expression of the Costimulatory Molecules, CD80, CD86 and CD154, in Orthotopic Liver Transplant Recipients

Le CD154 plaquettaire : Une nouvelle interface dans l’hémostase et la réaction inflammatoire

CD40-CD40 ligand

Contact Info

Product

Resources

About