CD44: A Multitude of Isoforms with Diverse Functions

Günthert, Ursula

doi:10.1007/978-3-642-78253-4_4

Cited by 139 publications

(119 citation statements)

References 58 publications

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“…CD44 presents a variety of forms that modulate its activity in various cellular functions including lymphocyte activation, adhesion, recirculation, and homing. For example, during hematopoiesis, its specific sialofucosylated glycoform, called HCELL, is found on human hematopoietic stem cells and functions as a ''bone homing receptor,'' directing migration of human hema- topoietic stem cells and mesenchymal stem cells to the bone marrow (26). Studies on hematopoietic cells differentiation demonstrated that the expression of CD15s (sLex) determinant is associated with the most primitive subset of bone marrowderived cells.…”

Section: Discussionmentioning

confidence: 99%

CD133 positive progenitor endothelial cell lines from human cord blood

et al. 2011

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Endothelial progenitor cells (EPCs) modulate postnatal vascularization and contribute to vessel regeneration in adults. Stem cells and progenitor cells were found in umbilical cord blood, bone marrow, and mobilized peripheral blood cells, from where they were isolated and cultured. However, the yield of progenitor cells is usually not sufficient for clinical application and the quality of progenitor cells varies.

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Section: Discussionmentioning

confidence: 99%

CD133 positive progenitor endothelial cell lines from human cord blood

et al. 2011

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“…The cytoplasmic tail embodies 6 putative serine phosphorylation sites and provides a connection to the cytoskeleton and to the tyrosine kinase family [rev. by [2,4,5,12,13]. Recent experiments assume that the juxtamembrane region of the cytoplasmic tail runs parallel to the negatively charged inner membrane because of its mostly basic residues.…”

Section: Protein Structurementioning

confidence: 99%

CD44 in hematological neoplasias

2011

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“…These factors are indeed triggered by the mechanical stretch (Nagano and Saya, 2004). CD44 is an important mediator in the regulation of interaction between ECM and cytoskeleton and is expressed in the ECM of all connective tissues (Gunthert, 1993). Intra-cytoplasmic domain of CD44 has binding sites for actin filaments.…”

Section: Cellular Mechanotransductionmentioning

confidence: 99%

Mechanoregulation of gene expression in fibroblasts

Wang

Thampatty

Lin

et al. 2007

Gene

227

187

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Mechanical loads placed on connective tissues alter gene expression in fibroblasts through mechanotransduction mechanisms by which cells convert mechanical signals into cellular biological events, such as gene expression of extracellular matrix components (e.g., collagen). This mechanical regulation of ECM gene expression affords maintenance of connective tissue homeostasis. However, mechanical loads can also interfere with homeostatic cellular gene expression and consequently cause the pathogenesis of connective tissue diseases such as tendinopathy and osteoarthritis. Therefore, the regulation of gene expression by mechanical loads is closely related to connective tissue physiology and pathology. This article reviews the effects of various mechanical loading conditions on gene regulation in fibroblasts and discusses several mechanotransduction mechanisms. Future research directions in mechanoregulation of gene expression are also suggested.

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CD44: A Multitude of Isoforms with Diverse Functions

Cited by 139 publications

References 58 publications

CD133 positive progenitor endothelial cell lines from human cord blood

CD133 positive progenitor endothelial cell lines from human cord blood

CD44 in hematological neoplasias

Mechanoregulation of gene expression in fibroblasts

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