CD45RA and CD45RO isoforms in infected malnourished and infected well-nourished children

Nájera, Oralia; González, Cristina; Toledo, G.; López, Laura Svidler; Cortés, Edith; Betancourt, Miguel; Ortiz, Rocı́o

doi:10.1046/j.1365-2249.2001.01694.x

Cited by 61 publications

(54 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our laboratory, it has been demonstrated that malnourished children show a lower proportion of memory cells (CD45RO ϩ ) than well-nourished children (27). A previous study showed that the reduced proportion of IL-2-producing cells is predominantly associated with a decreased proportion of IL-2-producing CD45RO ϩ cells (4).…”

Section: Discussionmentioning

confidence: 90%

Assessment by Flow Cytometry of Cytokine Production in Malnourished Children

Rodrı́guez

González

Flores

et al. 2005

Clin Vaccine Immunol

102

View full text Add to dashboard Cite

Malnutrition in children is associated with an increased risk of infection and death. Multiple abnormalities in the immune response, including cytokine production, in protein energy-malnourished children have been described and could account for the increased severity and frequency of infections. In this study, we used flow cytometry to investigate the effects of malnutrition on the production of cytokines ؉ and CD8 ؉ cells to produce IL-2, IFN-␥, IL-4, and IL-10 in response to stimulus. We concluded that both cytokine production and activation capacity were impaired in malnourished children. This functional impairment may be involved in the failure to develop a specific immune response and the predisposition to infection in these children.Malnutrition remains one of the most common causes of morbidity and mortality among children throughout the world (1). It is estimated that, in developing countries, more than one-quarter of all children younger than 5 years of age are malnourished (37). Malnutrition has been identified as an important risk factor for predisposition to infections leading to death (36). The strong association between malnutrition and infections has been established through epidemiologic studies conducted in several different countries. The severity of malnutrition determines the risk of death and/or severity of infections (17).Multiple abnormalities in the immune response, including T-cell number, ratio of T-cell subsets, NK cell activity, and cytokine production, have been described in connection with protein energy malnutrition. Nevertheless, results of studies investigating these topics are controversial (13,23,29). Several studies on the effects of malnutrition at the immunological level have been carried out with humans and experimental animals. These studies indicate that malnutrition decreases T-cell function, cytokine production, and the ability of lymphocytes to respond appropriately to cytokines (8,20,6).

show abstract

Section: Discussionmentioning

confidence: 90%

Assessment by Flow Cytometry of Cytokine Production in Malnourished Children

Rodrı́guez

González

Flores

et al. 2005

Clin Vaccine Immunol

102

View full text Add to dashboard Cite

show abstract

“…Malnourished infected children from developing countries have shown higher fractions of Ddull lymphocytes and lower fractions of memory lymphocytes than well-nourished infected children. Impairment of the transformation of the Ddull cells in memory cells in malnourished children may explain these findings and may be one of the mechanisms involved in immunodeficiency in these children (17). Whether or not this immunological condition promotes the establishment of carrier states and the wide spectrum of Campylobacter species isolated among malnourished children deserves further studies.…”

mentioning

confidence: 96%

Occurrence of campylobacter species in healthy well-nourished and malnourished children

Fernández

Vera

Villanueva

et al. 2008

Braz. J. Microbiol.

View full text Add to dashboard Cite

The occurrence of Campylobacter species in healthy, well-nourished and healthy, malnourished children of low socioeconomic level in Southern Chile was determined. Campylobacter carriers were significantly most frequent among malnourished (31.4%) than among well-nourished (9.9%) children. Six species were isolated from malnourished children whereas four were found among well-nourished children. C. upsaliensis was the most frequent (13.3%) species isolated from malnourished children, followed by C. lari (7.6%) and C. fetus ssp. fetus (1.9%).

show abstract

“…CD3 + CD4 + CD45RA -CD45RO + T cell counts varied over time from a significant reduction during the first week of follow up to elevated numbers in survivors during the last two weeks of the study (Figures 2a,c). The analysis of effector subsets, characterised by being double positive (CD45RA + CD45RO + ) (Hermiston et al 2003;Najera et al 2001), showed that were significantly reduced in both CD4 + and CD8 + T lymphocyte subsets at baseline, 3 and 7 days in both groups of patients compared with controls and in survivors compared with nonsurvivors at 3 days. From day 7 of follow up onwards, these values normalised in the surviving patients (Figures 2b,e).…”

Section: Septic Shock Patients With Different Outcomes Show Differentmentioning

confidence: 99%