CD5-positive follicular lymphoma: clinicopathologic correlations and outcome in 88 cases

Background: Follicular lymphoma is an indolent B Non Hodgkin lymphoma which has a characteristic follicular growth pattern and immunohistochemical expression. The neoplastic cells express CD20, CD10, and BCL2 and are negative for CD5, CD23 and Cyclin D1. CD5 is a useful marker in the differentiation of various B cell lymphomas. Small cell lymphoma and mantle cell lymphoma express CD5. Some of the follicular lymphomas express CD5 which results in diagnostic confusion Methods: 52 cases of lymphoma were diagnosed over a period of 2 years in a tertiary care centre in south India. Among these, 9 cases were diagnosed as follicular lymphoma based on the morphological and immunohistochemical study. A panel of antibodies was chosen based on the morphological diagnosis. The panel used for small cell lymphomas include CD20, CD3, CD5 CD23, Cyclin D1, CD10, BCL2 and Ki67. Result:Of the nine cases of follicular lymphoma, three were CD5 positive. Two showed bone marrow involvement. There was no significant morphological difference between CD5 positive and CD5 negative follicular lymphoma. Conclusion:The expression of CD5 by follicular lymphomas could be problematic when the follicular lymphoma as such lacks its characteristic follicular pattern andwhen there are no molecular studies available. Even though rare, follicular lymphoma is to be considered in the differential diagnosis of CD5 positive lymphomas.

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“…[15,16] It has also been found to be expressed in follow up biopsies of FL which initially did not express.…”

Section: Resultsmentioning

confidence: 99%

CD5 positive follicular lymphomas: A diagnostic dilemma in a resource restricted laboratory setting

Shanmuga

Angaraju

Ganesan

et al. 2017

APALM

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“…More interestingly, our case showed CD5 to be strongly and extensively positive in tumor cells, with aberrant co‐expression of CD5, CD10, and IFR4/MUM1. CD5‐positive FL and DLBCL in adults were correlated with a more aggressive clinical course as well as worse prognosis …”

Section: Discussionmentioning

confidence: 99%

IFR4/MUM1-positive lymphoma in Waldeyer ring with co-expression of CD5 and CD10

Chen

Al-Kzayer

Liu

et al. 2016

Pediatr Blood Cancer

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IRF4/MUM1-positive lymphoma is a new subgroup of germinal center-derived B-cell lymphoma, predominantly involving the Waldeyer ring (WR) in children. CD5 expression is rare in these lymphomas. We report a 7-year-old Chinese male with B-cell lymphoma. Evaluation of his specimen by morphology, immunohistochemistry, and FISH analysis demonstrated IRF4/MUM1-positive lymphoma with strong and extensive CD5 and CD10 positivity. Despite the lack of t(14;18)(q32;q21) rearrangement, BCL2 protein was expressed. Our report highlights the clinicopathologic features of IFR4/MUM1-positive lymphoma in WR with co-expression of CD5 and CD10, and thereby provides insight into this newly recognized disease entity.

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“…IRTA-1 is specific for marginal zone B-cell lymphoma and is useful for diagnosis. 13 Li Y et al 14 reported 88 patients with CD5-positive follicular lymphoma. For MZL, CD5-positive patients often exhibit dissemination, bone marrow involvement, and/or leukemic state.…”

Section: Other Cd5-positive Lymphomasmentioning

confidence: 99%

Differential diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma and other indolent lymphomas, including mantle cell lymphoma

Yoshino

Tanaka

Sato

2020

JCEH

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Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) usually exhibits heterogeneous features such as ill-defined bright nodules, termed proliferation centers, with chromatin-rich background cells (Figure 1). The proliferation centers are composed of paraimmunoblasts, which are medium-sized cells, and the Ki67 index of these cells is higher than that of ordinary CLL/SLL cells. On the contrary, the majority of CLL/SLL cells are usually "small" lymphoma cells, but they are slightly larger than normal lymphocytes (Figure 2). In some cases, paraimmunoblasts are prominent and such cases should be differentiated from follicular lymphomas. By lymphoma-cell morphology and immunostaining, this differential diagnosis is simple. CLL/ SLL cases may exhibit prominent paraimmunoblasts (Figure 3). Such cases should not be diagnosed as Richter syndrome because it features large blast cells; one feature of diffuse large B-cell lymphoma is the monotonous proliferation of large cells (the nucleus is more than twice the size of that of normal lymphocytes with varying cytoplasm sizes) (Figure 4). Bone marrow biopsy demonstrates many features. Some cases exhibit a nodular pattern of infiltration, or interstitial or mixed nodular and interstitial pattern, whereas others have

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CD5-positive follicular lymphoma: clinicopathologic correlations and outcome in 88 cases

Cited by 29 publications

References 40 publications

CD5 positive follicular lymphomas: A diagnostic dilemma in a resource restricted laboratory setting

CD5 positive follicular lymphomas: A diagnostic dilemma in a resource restricted laboratory setting

IFR4/MUM1-positive lymphoma in Waldeyer ring with co-expression of CD5 and CD10

Differential diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma and other indolent lymphomas, including mantle cell lymphoma

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