2014
DOI: 10.1016/j.canlet.2013.11.013
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CD68+HLA-DR+ M1-like macrophages promote motility of HCC cells via NF-κB/FAK pathway

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Cited by 89 publications
(74 citation statements)
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“…TAMs can promote progression and metastasis through the release of a variety of chemokines, inflammatory factors, and growth factors. It is reported that CD68 + HLA-DR + TAMs in hepatocellular carcinoma (HCC) can promote migration of HCC cells via the NF- κ B/FAK pathway [66]. Specifically, TAM-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner [67].…”
Section: Tams Remodel the Tumor Microenvironmentmentioning
confidence: 99%
“…TAMs can promote progression and metastasis through the release of a variety of chemokines, inflammatory factors, and growth factors. It is reported that CD68 + HLA-DR + TAMs in hepatocellular carcinoma (HCC) can promote migration of HCC cells via the NF- κ B/FAK pathway [66]. Specifically, TAM-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner [67].…”
Section: Tams Remodel the Tumor Microenvironmentmentioning
confidence: 99%
“…There are, however, a number of aberrant biological mechanisms that contribute to the onset, growth, progression, and metastasis of HCC (Burkhart et al, ; Galuppo et al, ; Jiang et al, ; Yu et al, ). One of the most prominently dysregulated pathways in HCC is the NF‐κB pathway, which likely contributes greatly to the morbidity and mortality of the disease (Li, Tan, Zenali, & Brown, ; Wang et al, , ). Understanding how this pathway is regulated in the development of HCC is therefore crucial to progressing toward improved HCC treatment.…”
Section: Discussionmentioning
confidence: 99%
“…Concurrently, high level of NF-κB signaling and activity promote migration and invasive abilities of liver cancer cells (50). Moreover, NF-κB pathway is involved on reduced radiotherapeutics and chemotherapeutics sensitivity of HCC cells (51).…”
Section: P65mentioning
confidence: 99%